University of Groningen
Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome
Wang, Xiaoyan
DOI:
10.33612/diss.135858262
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wang, X. (2020). Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome: Pathology and treatment. University of Groningen. https://doi.org/10.33612/diss.135858262
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Salivary gland progenitor cells and epithelium
in primary Sjögren’s syndrome
Pathology and treatment
yŝĂŽLJĂŶtĂŶŐ
dŚĞƌĞƐĞĂƌĐŚƉƌĞƐĞŶƚĞĚŝŶƚŚŝƐƚŚĞƐŝƐǁĂƐƐƵƉƉŽƌƚĞĚďLJŐƌĂŶƚƐĨƌŽŵ͗ ŚŝŶĂ ^ĐŚŽůĂƌƐŚŝƉ ŽƵŶĐŝů ;^ ŐƌĂŶƚ EŽ͘ ϮϬϭϲϬϲϮϮϬϬϳϰͿ͕ ƵƚĐŚ ƌƚŚƌŝƚŝƐ &ŽƵŶĚĂƚŝŽŶdƌĂŶƐůĂƚŝŽŶĂůZĞƐĞĂƌĐŚŐƌĂŶƚ;dϬϭϱͲϬϱϮͿ͕ƵƚĐŚƌƚŚƌŝƚŝƐ&ŽƵŶĚĂƚŝŽŶ >ŽŶŐdĞƌŵWƌŽũĞĐƚŐƌĂŶƚ;>>WͲϮϵͿ͕ĂŶĚĚĞ^ƚŝĐŚƚŝŶŐĞŽĐŬͲ,ĂĚĚĞƌƐ;EŽ͘ϮϬϭϵͲ ϳϮĂŶĚEŽ͘ϮϬϮϬͲϳϬͿ dŚĞƌĞƐĞĂƌĐŚƉƌĞƐĞŶƚĞĚŝŶƚŚŝƐƚŚĞƐŝƐǁĂƐƉĞƌĨŽƌŵĞĚĂƚ͗ dŚĞ^ũƂŐƌĞŶ͛ƐƐLJŶĚƌŽŵĞĞdžƉĞƌƚŝƐĞĐĞŶƚƌĞ͕hŶŝǀĞƌƐŝƚLJDĞĚŝĐĂůĞŶƚĞƌ'ƌŽŶŝŶŐĞŶ͘ dŚĞƉƌŝŶƚŝŶŐĂŶĚĚŝƐƚƌŝďƵƚŝŽŶŽĨƚŚŝƐƚŚĞƐŝƐǁĞƌĞƐƵƉƉŽƌƚĞĚďLJ͗ ZŝũŬƐƵŶŝǀĞƌƐŝƚĞŝƚ'ƌŽŶŝŶŐĞŶ dŚĞ'ƌĂĚƵĂƚĞ^ĐŚŽŽůŽĨDĞĚŝĐĂů^ĐŝĞŶĐĞƐ͕hŶŝǀĞƌƐŝƚLJDĞĚŝĐĂůĞŶƚĞƌ'ƌŽŶŝŶŐĞŶ dŚĞƵƚĐŚĂƐƐŽĐŝĂƚŝŽŶŽĨ^ũƂŐƌĞŶΖƐƉĂƚŝĞŶƚƐ;Es^WͿ ŽǀĞƌ͗DĞŶŐLJŝŶŐyŝĂŽ͕yŝĂŽLJĂŶtĂŶŐ >ĂLJŽƵƚ͗^ŚĂŽĐŚƵĂŶ&ĞŶŐ WƌŝŶƚŝŶŐ͗/ƉƐŬĂŵƉWƌŝŶƚŝŶŐ /^E͗ϵϳϴͲϵϰͲϲϰϮϭͲϬϱϳͲϲ ΞyŝĂŽLJĂŶtĂŶŐ͕'ƌŽŶŝŶŐĞŶ͕ϮϬϮϬ͘ ůůƌŝŐŚƚƐƌĞƐĞƌǀĞĚ͘EŽƉĂƌƚŽĨƚŚŝƐƉƵďůŝĐĂƚŝŽŶŵĂLJďĞƌĞƉƌŽĚƵĐĞĚŽƌƚƌĂŶƐŵŝƚƚĞĚ ŝŶĂŶLJĨŽƌŵŽƌďLJĂŶLJŵĞĂŶƐǁŝƚŚŽƵƚƉĞƌŵŝƐƐŝŽŶŽĨƚŚĞĂƵƚŚŽƌ͘
^ĂůŝǀĂƌLJŐůĂŶĚƉƌŽŐĞŶŝƚŽƌĐĞůůƐĂŶĚĞƉŝƚŚĞůŝƵŵŝŶ
ƉƌŝŵĂƌLJ^ũƂŐƌĞŶ͛ƐƐLJŶĚƌŽŵĞ
WĂƚŚŽůŽŐLJĂŶĚƚƌĞĂƚŵĞŶƚ
WŚƚŚĞƐŝƐ ƚŽŽďƚĂŝŶƚŚĞĚĞŐƌĞĞŽĨWŚĂƚƚŚĞ hŶŝǀĞƌƐŝƚLJŽĨ'ƌŽŶŝŶŐĞŶ ŽŶƚŚĞĂƵƚŚŽƌŝƚLJŽĨƚŚĞ ZĞĐƚŽƌDĂŐŶŝĨŝĐƵƐWƌŽĨ͘͘tŝũŵĞŶŐĂ ĂŶĚŝŶĂĐĐŽƌĚĂŶĐĞǁŝƚŚ ƚŚĞĚĞĐŝƐŝŽŶďLJƚŚĞŽůůĞŐĞŽĨĞĂŶƐ͘ dŚŝƐƚŚĞƐŝƐǁŝůůďĞĚĞĨĞŶĚĞĚŝŶƉƵďůŝĐŽŶ tĞĚŶĞƐĚĂLJϮϴKĐƚŽďĞƌϮϬϮϬĂƚϵ͘ϬϬŚŽƵƌƐ ďLJ yŝĂŽLJĂŶtĂŶŐ ďŽƌŶŽŶϰKĐƚŽďĞƌϭϵϵϬ ŝŶ^ŚĂŶĚŽŶŐ͕ŚŝŶĂ^ƵƉĞƌǀŝƐŽƌƐ
WƌŽĨ͘&͘'͘D͘<ƌŽĞƐĞ WƌŽĨ͘,͘ŽŽƚƐŵĂŽͲƐƵƉĞƌǀŝƐŽƌ
ƌ͘^͘͘WƌŝŶŐůĞƐƐĞƐƐŵĞŶƚŽŵŵŝƚƚĞĞ
WƌŽĨ͘E͘͘ŽƐ WƌŽĨ͘^͘͘͘ǀĂŶ/ũnjĞŶĚŽŽƌŶ WƌŽĨ͘^͘ŽŵďĂƌĚŝĞƌŝWĂƌĂŶLJŵƉŚƐ
ƌ͘'͘D͘W͘:͘sĞƌƐƚĂƉƉĞŶ
ᄇࢶྱቸዾࢶነႤቪේेռݨ
To all the people who gave me courage and love
Table of contents
Chapter 1
Introduction
Expert Opin. Investig. Drugs 2019, 28: 605–616. Clin Exp Rheumatol. In press.
11
Chapter 2
Dysregulation of NFɈB in glandular epithelial
cells results in Sjögren’s like features
PLoS ONE. 2018, 13: e0200212.
39
Chapter 3
Salivary gland progenitor cells age prematurely
in primary Sjögren’s syndrome
Arthritis Rheumatol. 2019, 71:133-142.
61
Chapter 4
Progenitor cell niche senescence reflects
pathology of the parotid salivary gland in
primary Sjögren’s syndrome
Rheumatology. 2020, 11: keaa012.
93
Chapter 5
Senescent stem and transient amplifying cells
in Crohn’s disease intestine
Inflamm Bowel Dis. 2020, 26: e8-e9.
121
Chapter 6
Ⱦ-adrenergic signaling controls human salivary
gland progenitor cells via the notch pathway
Manuscript in preparation.
129
Chapter 7
Summary and discussion
Clin Exp Rheumatol. In press.