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University of Groningen Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome Wang, Xiaoyan

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University of Groningen

Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome

Wang, Xiaoyan

DOI:

10.33612/diss.135858262

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Wang, X. (2020). Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome: Pathology and treatment. University of Groningen. https://doi.org/10.33612/diss.135858262

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Salivary gland progenitor cells and epithelium

in primary Sjögren’s syndrome

Pathology and treatment



yŝĂŽLJĂŶtĂŶŐ

(3)

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ƉƌŝŵĂƌLJ^ũƂŐƌĞŶ͛ƐƐLJŶĚƌŽŵĞ

WĂƚŚŽůŽŐLJĂŶĚƚƌĞĂƚŵĞŶƚ

WŚƚŚĞƐŝƐ ƚŽŽďƚĂŝŶƚŚĞĚĞŐƌĞĞŽĨWŚĂƚƚŚĞ hŶŝǀĞƌƐŝƚLJŽĨ'ƌŽŶŝŶŐĞŶ ŽŶƚŚĞĂƵƚŚŽƌŝƚLJŽĨƚŚĞ ZĞĐƚŽƌDĂŐŶŝĨŝĐƵƐWƌŽĨ͘͘tŝũŵĞŶŐĂ ĂŶĚŝŶĂĐĐŽƌĚĂŶĐĞǁŝƚŚ ƚŚĞĚĞĐŝƐŝŽŶďLJƚŚĞŽůůĞŐĞŽĨĞĂŶƐ͘  dŚŝƐƚŚĞƐŝƐǁŝůůďĞĚĞĨĞŶĚĞĚŝŶƉƵďůŝĐŽŶ  tĞĚŶĞƐĚĂLJϮϴKĐƚŽďĞƌϮϬϮϬĂƚϵ͘ϬϬŚŽƵƌƐ    ďLJ   yŝĂŽLJĂŶtĂŶŐ  ďŽƌŶŽŶϰKĐƚŽďĞƌϭϵϵϬ ŝŶ^ŚĂŶĚŽŶŐ͕ŚŝŶĂ

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^ƵƉĞƌǀŝƐŽƌƐ

WƌŽĨ͘&͘'͘D͘<ƌŽĞƐĞ  WƌŽĨ͘,͘ŽŽƚƐŵĂ 

ŽͲƐƵƉĞƌǀŝƐŽƌ

ƌ͘^͘͘WƌŝŶŐůĞ 

ƐƐĞƐƐŵĞŶƚŽŵŵŝƚƚĞĞ

WƌŽĨ͘E͘͘ŽƐ  WƌŽĨ͘^͘͘͘ǀĂŶ/ũnjĞŶĚŽŽƌŶ  WƌŽĨ͘^͘ŽŵďĂƌĚŝĞƌŝ  

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ᄇࢶྱቸዾࢶነႤቪේेռݨ๩

To all the people who gave me courage and love

(9)





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Table of contents



Chapter 1

Introduction

Expert Opin. Investig. Drugs 2019, 28: 605–616. Clin Exp Rheumatol. In press.

11

Chapter 2

Dysregulation of NFɈB in glandular epithelial

cells results in Sjögren’s like features

PLoS ONE. 2018, 13: e0200212.

39

Chapter 3

Salivary gland progenitor cells age prematurely

in primary Sjögren’s syndrome

Arthritis Rheumatol. 2019, 71:133-142.

61

Chapter 4

Progenitor cell niche senescence reflects

pathology of the parotid salivary gland in

primary Sjögren’s syndrome

Rheumatology. 2020, 11: keaa012.

93

Chapter 5

Senescent stem and transient amplifying cells

in Crohn’s disease intestine

Inflamm Bowel Dis. 2020, 26: e8-e9.

121

Chapter 6

Ⱦ-adrenergic signaling controls human salivary

gland progenitor cells via the notch pathway

Manuscript in preparation.

129

Chapter 7

Summary and discussion

Clin Exp Rheumatol. In press.

165

Chapter 8 Nederlandse samenvatting

191

䐱㸥䍋䄋

199

Acknowledgments

203

Curriculum

vitae

211

List of publications

213

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