University of Groningen
Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome
Wang, Xiaoyan
DOI:
10.33612/diss.135858262
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wang, X. (2020). Salivary gland progenitor cells and epithelium in primary Sjögren’s syndrome: Pathology and treatment. University of Groningen. https://doi.org/10.33612/diss.135858262
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Stellingen behorende bij het proefschrift
Salivary gland progenitor cells and epithelium in primary
Sjögren’s syndrome: Pathology and treatment
1. Salivary gland progenitor cells in primary Sjögren’s syndrome patients are prone to be senescent (this thesis).
2. The NFκB pathway is activated in salivary gland epithelial cells in primary Sjögren’s syndrome (this thesis).
3. The senescence of salivary gland progenitor cells may be an intermediate link between inflammation and dysfunction in the salivary gland of primary Sjögren’s syndrome patients (this thesis).
4. Progenitor cell niche senescence might be a common feature in epithelial target organs of proinflammatory autoimmune diseases (this thesis). 5. In clinical trials of primary Sjögren’s syndrome, particular attention is
needed to the functioning of the salivary gland epithelium (this thesis). 6. Improvement of salivary gland progenitor cell function in primary
Sjögren’s syndrome is of vital importance for the restoration of patient salivary gland function (this thesis).
7. The establishment of in vitro salivary gland organ using 3D organoid cultures, instead of 2D cultures, will help profoundly in understanding the dynamics of salivary gland epithelium (this thesis). 8. Notch signaling plays a critical role in controlling salivary gland progenitor cells (this thesis). 9. Don’t make excuses for failure, only find ways to succeed. 10. Those who do not plan for the future will find trouble at their doorstep (Confucius). 11. Everything has its positive side. During the Corona crisis, at least I could focus on writing.
