University of Groningen
Endothelial cell transcriptional regulation in vascular disease
Sol, Marloes
DOI:
10.33612/diss.136419916
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Publication date:
2020
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Citation for published version (APA):
Sol, M. (2020). Endothelial cell transcriptional regulation in vascular disease. University of Groningen.
https://doi.org/10.33612/diss.136419916
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Endothelial cell transcriptional
regulation in vascular disease
Marloes Sol
© Marloes Sol, 2020
All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without permission of the author.
Front cover design: Ilse Modder, The Netherlands | www.ilsemodder.nl Lay-out: Ilse Modder, The Netherlands | www.ilsemodder.nl
Print: Gildeprint, The Netherlands | www.gildeprint.nl
This project was financially supported by:
Dutch Kidney Foundation (grant 15OP13) Jan Kornelis de Cock-Hadders Foundation Graduate School of Medical Sciences
The printing of this dissertation was kindly supported by:
University of Groningen
University Medical Center Groningen Graduate School of Medical Sciences Stichting Hartpatiënten Nederland NierNieuws
Endothelial cell transcriptional
regulation in vascular disease
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
dinsdag 10 november 2020 om 12.45 uur
door
Marloes Sol
geboren op 29 januari 1992
te Groningen
Promotores
Prof. dr. J.L. Hillebrands Prof. dr. J. van der Vlag
Copromotores
Dr. G. Krenning Dr. J.A.A.M. KampsBeoordelingscommissie
Prof. dr. S.P. Berger Prof. dr. M.G. Rots Prof. dr. H.P. HammesParanimfen
Ana Maria Almonacid Suarez Josée Plantinga
CONTENTS
CHAPTER 1 General introduction and outline of the thesis
CHAPTER 2 Glomerular endothelial cells as instigators of glomerular
sclerotic diseases
CHAPTER 3 Enhancer of Zeste Homolog 2 compromises the
glomerular endothelial glycocalyx in diabetic nephropathy
CHAPTER 4 Glomerular endothelial cell-specific targeting of
Enhancer of Zeste Homolog 2 in experimental diabetic nephropathy
CHAPTER 5 Peroxisome proliferator-activated receptor ɣ agonist
mediated inhibition of heparanase expression reduces proteinuria
CHAPTER 6 Reciprocal regulation of endothelial-mesenchymal
transition by MAPK7 and EZH2 activity in intimal hyperplasia and coronary artery disease.
CHAPTER 7 Summary, translational aspects and future perspectives APPENDICES Dutch summary
Acknowledgements About the author
11 29 57 87 115 137 161 178 184 191
