University of Groningen
Towards personalized cardiovascular risk management in renal transplant recipients
de Vries, Laura Victorine
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
de Vries, L. V. (2018). Towards personalized cardiovascular risk management in renal transplant recipients.
Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Towards Personalized
Cardiovascular Risk Management
in Renal Transplant Recipients
Laura V. de Vries
Towards Personalized Cardiovascular Risk Management in Renal Transplant Recipients
PhD dissertation, University of Groningen, the Netherlands
Financial support by the University of Groningen, University Medical Center Groningen, Groningen Graduate School of Medical Sciences, Dutch Kidney Foundation, Neder-landse Transplantatie Vereniging, and Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Further financial support for the printing of this thesis was kindly provided by Astellas Pharma B.V., Chiesi Pharmaceuticals B.V., ChipSoft, Eurocept Homecare, Fresenius Medical Care Nederland B.V., Noord Negentig Accountants & Belastingadviseurs, Sanofi, Spark Holland B.V., and Van der Meer Accountants & Adviseurs.
Cover design & lay-out: Evelien Jagtman (evelienjagtman.com) Printed by: Gildeprint Drukkerijen, Enschede
ISBN: 978-94-6233-890-6 (printed version) ISBN: 978-94-034-0503-2 (digital version)
© Copyright 2018, L.V. de Vries, Groningen, the Netherlands
All rights reserved. No part of this publication may be reproduced, copied, modified, stored in a retrieval system, or transmitted in any form without prior written permis-sion of the author.
Towards Personalized
Cardiovascular Risk Management
in Renal Transplant Recipients
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 11 april 2018 om 14.30 uur
door
Laura Victorine de Vries
geboren op 3 augustus 1986 te Zeist
Promotores
Prof. dr. S.J.L. Bakker Prof. dr. G.J. Navis Prof. dr. I.P. Kema
Beoordelingscommissie
Prof. dr. J.J. Homan van der Heide Prof. dr. R.J. Porte
Paranimfen
Drs. M.A. van den Boomgaard Dr. J.C. Tanis
Chapter 2
Chapter 6
Chapter 4
Chapter 3
1
Chapter 4
Chapter 1
Introduction and Aims of Thesis Chapter 2
Effects of Dietary Sodium Restriction in Kidney Transplant Recipients Treated With Renin-Angiotensin-Aldosterone System Blockade: A Randomized Clinical Trial
Am J Kidney Dis. 2016 Jun;67(6):936-44 Chapter 3
Aldosterone, From (Patho)Physiology to Treatment in Cardiovascular and Ren-al Damage
Curr Vasc Pharmacol. 2011 Sep;9(5):594-605 Chapter 4
Twenty-four Hour Urinary Cortisol Excretion and the Metabolic Syndrome in Prednisolone-Treated Renal Transplant Recipients
Steroids. 2017 Sep 8;127:31-39 Chapter 5
Endogenous Glucocorticoid Metabolites and Mortality in Prednisolone-Treated Renal Transplant Recipients
Submitted Chapter 6
The Tryptophan-Kynurenine Pathway, Systemic Inflammation, and Long-Term Outcome after Kidney Transplantation
Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F475-F486 Chapter 7
Summary and General Discussion Chapter 8
Nederlandse Samenvatting (voor niet-ingewijden) Appendix Dankwoord / Acknowledgements
About the Author Author Affiliations 11 33 53 83 113 137 169 193 205 215 219
CONTENTS
ITHACA
When you set out for distant Ithaca, fervently wish your journey may be long, —
full of adventures and with much to learn. Of the Laestrygones and the Cyclopes, of the angry god Poseidon, have no fear: these you shall not encounter, if your thought
remains at all times lofty, — if select emotion touches you in body and spirit. Not the Laestrygones, not the Cyclopes, nor yet the fierce Poseidon, shall you meet,
unless you carry them within your soul, — unless your soul should raise them to confront you.
Fervently wish your journey may be long. May they be numerous — the summer mornings when, pleased and joyous, you will be anchoring
in harbours you have never seen before. Stay at the populous Phoenician marts, and make provision of good merchandise;
coral and mother of pearl; and ebony and amber; and voluptuous perfumes
of every kind, in lavish quantity. Sojourn in many a city of the Nile, and from the learned learn and learn amain.
At every stage bear Ithaca in mind. The arrival there is your appointed lot.
But hurry not the voyage in the least: ’twere better if you travelled many years and reached your island home in your old age,
being rich in riches gathered on the way, and not expecting more from Ithaca.
Ithaca gave you the delightful voyage: without her you would never have set out:
and she has nothing else to give you now.
And though you should find her wanting, Ithaca will not surprise you; for you will arrive wise and experienced, having long since perceived
the unapparent sense in Ithacas.
Κωνσταντίνος Π. Καβάφης, 1911 (origineel in Grieks)
