Assessment and clinical implications of functional vitamin B6 deficiency
Minovic, Isidor
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Minovic, I. (2018). Assessment and clinical implications of functional vitamin B6 deficiency. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Assessment and Clinical Implications of
Functional Vitamin B6 Deficiency
Assessment and Clinical Implications of Functional Vitamin B6 Deficiency Dissertation University of Groningen, Groningen, the Netherlands
The studies presented in this thesis were performed within the framework of Top Institute Food and Nutrition (research grant CH-002).
Financial support from the University of Groningen, University Medical Center Groningen, Graduate School for Drug Exploration (GUIDE), Dutch Kidney Foundation, and Dutch Heart Foundation is gratefully acknowledged.
Lay-out: Ridderprint BV & Studio Veendorp
Cover: Studio Veendorp | www.studioveendorp.com Printing: Ridderprint BV | www.ridderprint.nl ISBN: 978-94-034-0808-8 (printed version) ISBN: 978-94-034-0807-1 (digital version)
Additional financial support for the printing of this thesis was kindly provided by Chiesi Pharmaceuticals, Eurocept Homecare, Chipsoft B.V., Noord Negentig Accountants en Belastingadviseurs, and Astellas.
©I. Minović 2018.
All rights reserved. No part of this publication may be reproduced, copied, modified, stored in a retrieval system, or transmitted without prior written consent of the author.
Assessment and Clinical Implications of
Functional Vitamin B6 Deficiency
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op 11 juli 2018 om 11.00 uur
door
Isidor Minović
geboren op 8 december 1989 te Sarajevo, Bosnië en Herzegovina
Prof. dr. S.J.L. Bakker Prof. dr. I.P. Kema Prof. dr. M.E. Eggersdorfer Beoordelingscommissie Prof. dr. P.M. Ueland Prof. dr. P.M. ter Wee Prof. dr. P. Heeringa
Contents
Chapter 1 General Introduction 11
Chapter 2 Vitamin and Mineral Status in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: a Systematic Review and Meta-Analysis
31
Chapter 3 Vitamin B6, Inflammation, and Cardiovascular Outcome in the General Population: the Prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study
79
Chapter 4 Vitamin B6 Deficiency is Common and Associated with Poor Long-Term Outcome in Renal Transplant Recipients
105
Chapter 5 Functional Vitamin B6 Status and Long-Term Mortality in Renal Transplant Recipients
127
Chapter 6 The Tryptophan-Kynurenine Pathway, Systemic Inflammation, and Long-Term Outcome after Kidney Transplantation.
149
Chapter 7 Summary, General Discussion, and Future Perspectives 183 Nederlandse samenvatting / Dutch summary 201
Dankwoord / Acknowledgements 209
About the author 219
