University of Groningen
Endothelial cell transcriptional regulation in vascular disease
Sol, Marloes
DOI:
10.33612/diss.136419916
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Sol, M. (2020). Endothelial cell transcriptional regulation in vascular disease. University of Groningen. https://doi.org/10.33612/diss.136419916
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Stellingen behorend bij het proefschrift
‘Endothelial cell transcriptional regulation in vascular disease’
1. Targeting glomerular endothelial H3K27me3 is needed to prevent the reduction of the glomerular endothelial glycocalyx in diabetic nephropathy. (this thesis, Ch 3)
2. Glomerular endothelial EZH2 contributes to glomerular extracellular matrix deposition and glomerulosclerosis in diabetic nephropathy. (this thesis, Ch 4)
3. An inducible glomerular endothelium EZH2 knock out in vivo model is necessary to really understand the role of endothelial EZH2 in the development of diabetic nephropathy. (this thesis, Ch 3 & 4)
4. PPARɣ-mediated transcriptional repression of HPSE is essential to restore the integrity of the glomerular endothelial glycocalyx in Focal Segmental Glomerulosclerosis. (this thesis, Ch 5) 5. Disturbed reciprocal signaling between MAPK7 and EZH2 in endothelial cells induces
Endothelial-to-Mesenchymal Transition and contributes to coronary atherosclerosis. (this thesis, Ch 6)
6. Glomerular endothelial dysfunction underlies the development of proteinuria and kidney failure in COVID-19 patients.
7. De wetenschap laat zich niet plannen. 8. Docendo discitur. (Seneca)
Marloes Sol 10 november 2020
