To approach or to avoid : neurobiological mechanisms in social anxiety Peer, J.M. van
Hele tekst
(2) Chapter 4. Cortisol-induced enhancement of emotional face processing in social phobia depends on symptom severity and motivational context. ȋʹͲͲͻȌǡͺͳǡͳʹ͵Ǧͳ͵Ͳǡ ǣͳͲǤͳͲͳȀǤ ǤʹͲͲͻǤͲ͵ǤͲͲ ǤǤǡǤǡ Ǥ ǤǡƬǤ.
(3) Chapter4. Abstract ʹͲ ȋȌǤ Ǧ ȋȌ ǡ ȋȌ ȋȌ Ǥ ǡ Ǥ ǡ ȋͳͷͲȌ ǡ ȋ Ȍ Ǥ Ǧ Ǥ Ǧ Ǥ. .
(4) Effectsofcortisolinsocialanxiety. Introduction
(5) ǡ Ǧ ȋǤǡʹͲͲȌǤ ȋͳͷͲ͵ͲͲȌ ǡ Ǥ
(6) ǡ ǡ Ǧ Ǥ ǡ ȋȌǤ ǡ Ǥ ȋ Ȍ ȋǤǤǡǤǡͳͻͻͺǢǤǡʹͲͲͷǡ ʹͲͲǡʹͲͲͻǢǤǡʹͲͲͲǢ ǤǡͳͻͻͺǡʹͲͲͲǢǤǡʹͲͲȌǤ
(7) ǡ ȋǤǤǡǤǡʹͲͲͻǢǡ Ǥǡ ʹͲͲͷǢ Ƭ
(8) ǡ ʹͲͲͺȌǤ ǡ Ǧ ȋ Ǥǡ ʹͲͲ Ȍ Ǥǡ ǡ Ǥ Ǥ ȋʹͲͲȌ ȋ Ȍ Ǧ ǡ Ǧ Ǥ
(9) ǡ ǡ .
(10) Chapter4. ȋǤǡʹͲͲȌǤ ȋ Ǥǡ ͳͻͻͺǡ ǡ ʹͲͲͲǢ ǡ ͳͻͻͲȌǡ ȋƬ ǡͳͻͻͶȌ ȋ Ǥǡ ʹͲͲͻȌ Ǥ ǦǤȋʹͲͲȌ ȋ ȌǤ ȋǤǡʹͲͲͶǢƬǡʹͲͲͺǢ ǤǡʹͲͲǢǤǡʹͲͲȌ ȋ Ȍ Ǥ ȋ Ǥǡ ʹͲͲȌ ͳ Ǧ Ǧ ǡ Ǥ Ǧ ǡ ȋǤǤǡǤǡ ʹͲͲȌǤ ǡ ǡ ȋǤǤǡǡ ʹͲͲͺǢÚƬǡʹͲͲͶǢƬ ǡʹͲͲǢƬ ǡʹͲͲͷǢ ǤǡʹͲͲͻȌǤ ǡ ȋǤǤǡ Ú Ƭ ǡ ʹͲͲͶǢ Ƭ ǡ ʹͲͲͷ ȌǤ ǡ ǡ Ǧ ȋȌ Ǥ ȋȌ ȋ Ȍ ǡ ȋǤǤǡ Ǧ Ǥǡ ʹͲͲͷǢ ǡ ǡ Ƭ ǡ ʹͲͲȌǤ . ͺ.
(11) Effectsofcortisolinsocialanxiety. ǡ Ǥ ǡ ȋǤǤǡǤǡͳͻͻǢǡʹͲͲͲȌǤ ȋǤǤǡ δ ʹͷͲ ǦȌ Ǧ ȋǤǡʹͲͲͶǢǦ ǤǡʹͲͲͷǢǡ ǡ
(12) ǡƬǡʹͲͲ͵ǢƬ ǡʹͲͲʹǢ Ǥǡ ʹͲͲȌǡ ȋ Ƭ ǡ ʹͲͲʹǢ ǤǡʹͲͲͶǢǤǡʹͲͲȌǤ . Ǧ . ǡ Ǥ ȋƬ ǡʹͲͲǢǡǡǡƬǡʹͲͲȌǤ ȋƬǡʹͲͲȌǡ ȋ Ǥǡ ʹͲͲȌǤ ǡ Ǧ ǡ ǡ ȋ ǡǡƬ ǡʹͲͲͺ ȌǤ
(13) ǡ Ǧ Ǥ ȋʹͲͲͷȌ ȋʹȌ ǡ Ǥ ǡ ȋͳͷͲ ͵ͲͲȌ ȋ Ǥǡ ʹͲͲȌǤ ͳͷͲ͵ͲͲ Ǥ
(14) ǡ Ǥ ȋǤǤǡ Ȍ Ǧ ȋ Ǧ ǡ Ƭ ǡ ʹͲͲͶȌǡ Ǧ Ǥ . ͻ.
(15) Chapter4. Ǧ ȋǤǤǡƬǡͳͻͻͻǢƬǡʹͲͲͶǢǡͳͻͲȌ ȋ ǤǡʹͲͲǢǤǡʹͲͲͷǢǤǡʹͲͲȌǤ ȋ Ǥǡ ʹͲͲȌ ȋǤǤǡ Ȍ ȋǤǤǡ ȋͳͷͲȌ ȋ͵ͲͲȌ Ȍ Ǥ. Methods Participants Ǧ ȋǤǤǡ €ͶͲ ȌǤ ͶǤͳǤ Ǥ
(16) ǣ ȋ Ǧ
(17) Ȍ εͲ ȋǡ ͳͻͺȌǡ Ǧǡ ǦǦ ǡͳͺǦͷͷǤ ǡ Ǧǡ ǡ εͷǡ ǡ ǡ ͵ ǡ ͵ ʹͲ Ǥ ǡ ǡ ǡ ǡ ǡ Ǥ ǡ Ǥʹͳǡ ǡ ʹͲ ȋͻǡͳͳȌǤ. Ͳ.
(18) Effectsofcortisolinsocialanxiety. Table4.1. ȋαʹͲȌǤ M SD ȋȌ ͵ʹǤͺ ͳͲǤʹ
(19) ʹʹǤʹ ͵Ǥʹ
(20) ͳʹǤʹ Ǥͳ ͶʹǤͳ ͺǤͲ ͵Ǥ͵ ͳͲǤͲ ͺǤͶ ͳǤʹ
(21) ͳ͵ͳǤͲ ʹͳǤͲ
(22) ʹǤͺ ͳͲǤͻ
(23) ͳͲͶǤʹ ʹͳǤ
(24) Ǧ ͷͲǤ ͺǤͳ
(25) ʹͷǤͳ ͵Ǥ͵ ͵Ǥ͵ Ǥʹ Ǧͳ αͳȗ αͲ α Note:ȋ ȌǤ
(26) α Ǣ
(27) α
(28) ȋͲǦ ͵ȌǢα ȋ ͲǦʹǡ ͲǦʹǡͲǦͳͶͶȌǢ
(29) α
(30) ȋ ͲǦͳͻʹǡͲǦͺȌǢ
(31) αǦ
(32) ȋʹͲǦ ͺͲȌǢ
(33) α
(34) ȋǦʹͺȌǢα ȋͳ͵ǦͷʹȌǤ αͳͻǤ
(35) Ǧ
(36) Ǧ
(37) ȋ
(38) Ǧ
(39) ȌǤ
(40) ǡ ǡ ȗǡ ǡ Ǧ Ǥ
(41) ǡ ǡ ǡ ǡ Ǥ. .
(42) Ǧ
(43)
(44) ȋ
(45) Ǧ
(46) ǣ Ǥǡ ͳͻͻȌ Ǥ
(47) ȋ
(48) ǣ Ǥǡ ͳͻͺͻȌǡ
(49) ȋ ǡ ǡ ǡƬǡͳͻͻȌǡǦ
(50) ȋǡͳͻͺ͵Ȍǡ
(51) ȋ
(52) Ȁǣ Ƭ ǡ ͳͻͻͶȌǤͶǤͳǤ Materialsandprocedure Ǥ ȋʹͲͲȌǤ ȋͷͲ Ȍ Ǧǡ Ǧ Ǥ Ǥ ͳ Ǥ ǡ . ͳ.
(53) Chapter4. ͳʹǤͳͷ ǤǤ ǡ ͳʹǤ͵Ͳ ǤǤǡ ͳ Ǥ ǡ Ǧ ǡ Ǥ ǡ ȋ̱ ͳͷ Ȍ ȋ Ȍǡ Ǧ ǡ Ǥ ǡ Ǧ Ǧ ǡ Ǥ Cortisolandsubjectivemeasures ȋǡ ǡ ȌǤͳͷ ǡ ǦͷȋͲȌǡΪͲȋͳȌǡΪͳʹͲȋʹȌǡΪͳͲȋ͵Ȍ Ǥ ȋ
(54) ǡ ʹͲͳͲǡ Ȍǡ ȋǤǡʹͲͲ͵ȌǤ Ǧ ȋǡ ǡ ǡ ǡ Ͳǡ ͳǡ ͵Ȍ ȋ ǦȌ ͳͲͲ ȋȌǤ
(55) ǡ ȋ
(56) Ǧ ǣǡͳͻͺ͵ȌͲ͵Ǥ ApproachAvoidancetask
(57) Ǧ ȋ Ƭ ǡ ʹͲͲͶǢ Ǥǡ ʹͲͲȌǡ Ͳ ȋƬ ǡͳͻǢƬǡͳͻͺͺǢǤǡͳͻͻͺȌǤ ȋ͵Ͳǡ ͷͲΨ ȌǤ ͳʹǤͶ u ͺǤͻ ȋh u wȌǡ ͳͷǤ Ͳ ȋ ͶǤͳȌǤ ʹ.
(58) Effectsofcortisolinsocialanxiety. Figure4.1. Ǥ. ȋͳͲͲ Ȍǡ ͵ͲͲȋ ȌȋͳͲͲ ȌǤ ǦǦ ͳͷͲͲ ʹͷͲͲ Ǥ ȋ Ƭ ǡ ʹͲͲͶǡ ͳȌ Ǥ DzdzȋȌ ǡ ȋͳͲǤ͵ ǡ ȌǤǡ Ǥ ȋ ǤǤǡ Ƭ ǡ ͳͻͻͻǢ Ƭ ǡ ʹͲͲͶǢ ǡ ͳͻͲȌ ȋ Ȍǡ ȋ ȌǤ ǡ Ǧ ȋ Ȍ ȋ Ȍ ȋ Ǧ Ȍȋ Ǧ ȌǤ Ǧ Ǧ Ǥ Ǧ ȋ ǡ Ȍ ȋ ͵.
(59) Chapter4. ǡ Ȍ Ǥ Ǧ ǦȋǡȌǤ ǡ ǡ Ǥ Ͳ ǡ Ǧ Ǧ Ǧ Ǧ Ǧ Ǧ ȋ ȌǤ Ǧȋ ȌǤ Ǧ Ǧ Ǥ ʹͲǡ ȋ̱͵Ͳ Ȍ ǡ ʹͲ Ǥ ǣȋ Ȍ ȋȌ Ǥ ȋ
(60) Ȍ ǤȋȌ Ǥ Electrophysiologicalrecordinganddataanalyses ȋ Ȍ ͳͻ ͳͲȂʹͲ Ǧ ͵ȀͶǤ ǦǤ Ǧ ȋ Ȍ ǡ Ǥ Ǥ ͷȳǤ ͷͲͲ Ǧ ȋ ǡ ͳǤͲͷǡ ǡͳͻͻͺȂʹͲͲͶȌͳͲͲͲ ǡʹͲͲͺͲͲ Ǥ ȋ Ǥǡ ͳͻͺ͵ȌǤ ͲǤͲͳ ǦȋʹͶȀ ǦȌ͵ͷ Ǧ ȋͳʹ Ȁ ȌǤ . Ͷ.
(61) Effectsofcortisolinsocialanxiety. ͲǤͷͲ Ɋ ±ͷ Ɋ ͵ǡ Ͷǡ ǡ ͵ǡ Ͷǡ ǡ ͵ǡ Ͷǡ ȋͳǤʹΨȌǤ ȋ ȀȀȌǤ ȋǤǡʹͲͲȌ ͳͷͲ͵ͲͲ ȋ ǡ ǡ ȌǤ ǣ ͳͷͲ ȋ ͳʹͲȂʹͲͲ ǦȌ ͵ͲͲ ȋ ǡʹͲȂͶͲͲȌǤ ǡ Ǥ
(62)
(63) δ ͳͷͲ ε ͳͲͲͲ ȋ ͶǤΨ Ȍ Ǥ ȋMα͵ǤͲάͳǤͺΨȌǤ ǡ ǡ Ǧ ǡ ȋ Ȍ ȋ ͳͶǤͲǡ
(64) Ǥǡ ͳͻͺͻȂʹͲͲͷȌǤ ȋǤǤǡǦ ǤǡʹͲͲͷǢ Ǥǡ ʹͲͲͺȌ Ǧ ȋ ǡ ʹͲͲǢ Ǥǡ ʹͲͲͷȌ ǡ ȋ
(65) Ȍ ȋȌ ȋ ǤǡʹͲͲͳȌǤ Ǧ Ǥ Ǧ ǤͲͷǤ ȋ ȏ²ȐȌǤ Ǧ ȋȏȐȌǤ . Results Cortisolandsubjectivemeasures ȋȀȌȋͶǤʹȌ ǤʹuͶ. ͷ.
(66) Chapter4. Table4.2. ȋȀȌ ȋαͲȌ. ȋȌ Ǧͷ ΪͲȗȗȗ ΪͳʹͲȗȗȗ Ϊͳͷȗȗȗ. . M ͻǤ ͺǤ͵ Ǥ͵ Ǥ. SD ͵Ǥͷ ʹǤ ʹǤͷ ʹǤͶ. . . M ͻǤ ʹͻͶǤʹ ʹ͵ͲǤͲ ͳͷͳǤʹ. SD ͵Ǥ ʹͳ͵Ǥͷ ͳͺǤͷ ͳͷͷǤͳ. Note: Nα ͳ ȋ αʹȌ Ǧ ȋNαͳȌǤȗȗȗ Ǥ δǤͲͲͳ. . ȋ ǡ ȌȋͲǡͳǡʹǡ͵Ȍ uȋFȋ͵ǡͶͺȌαͺǤͶǡpαǤͲͲͲǡ²αͲǤͺ͵ȌǤ ǡ ǡ ȋͲǣFȋͳǡͳȌαǤͲͳǡpαǤͻʹȌǡ ȋͳǣFȋͳǡͳȌαͳͶǤͺͷǡp=ǤͲͲͲǢʹǣFȋͳǡͳȌαʹͳͶǤͳǡp=ǤͲͲͲǢ͵ǣFȋͳǡͳȌαͳʹͶǤͲͺǡp= ǤͲͲͲȌǤǦͳʹȋǤǤǡ ȌǤ ȋ Ȍ ȋ ǡ Ȍu
(67) ǦȋͲǡ͵Ȍǡǡǡǡ ȋͲǡͳǡ ͵ȌǤ
(68) Ǧ ǡ ǡ ǡ ǡ ȋ Fδ ʹǤͶǡ p > ǤͳͶȌǤ ȋFȋͳǡͳͺȌ α Ǥͷǡ p = ǤͲͳ͵ȌǤ ǡ ȋͲǣ FȋͳǡͳͺȌ α ͻǤͷͻǡ p = ǤͲͲȌǤ ǡ Ǧ Ǧ ȋ Ͳ Ȍ Ǥ Ǧ ȋFȋͳǡͳȌ α ͲǤʹǡ p = ǤʹȌǡ Ǥ . .
(69) Effectsofcortisolinsocialanxiety. Behavioralresults Initiationtimes(IT) ǣ u ȋFȋͳǡͳͺȌ α ͷǤͶǡ p = ǤͲʹͻǡ ; α ǤʹͶȌ Ǧ ȋ ǣ M α Ͷͻͷ ± ʹ Ǣ ǣMαͷͲͻ± ͷͻȌ Ǧ ȋǣM αͷʹͶ± ͺǢ ǣMαͷʹͳ±ͶȌǤ
(70) ǡ ȋ u u ǣ FȋͳǡͳͺȌ α ͳǤͲͷǡ p = Ǥ͵ͳȌǤ ǡ ȋFȋͳǡͳͺȌαǤͷͻǡp=ǤͲͳͻǡɄ;αǤʹǡRαǦͲǤͷʹȌǡ ȋuu ǣFȋͳǡͳͺȌαʹǤͶͺǡp=Ǥͳ͵ȌǤ ȋFδͳǤͺ͵ǡpεǤͳͻȌǤ Movementtimes(MT) ȋFȋͳǡͳͺȌ α ͶǤͺͲǡ p = ǤͲͶʹȌǡ Ǥ
(71) ǡ u ȋFȋͳǡͳͺȌ α ͵Ǥʹǡ p = ǤͲ͵ǡ ² α ǤͳȌǡ Ǧ ȋ ǣMαͳͺͻ±ͺͻǢǣMα ͳͺͶ±ͶȌ Ǧ ȋǣMαͳͺͺ± ͺǢ ǣ M α ͳͻͻ ± ȌǤ
(72) ǡ u ȋFȋͳǡͳͺȌαͷǤͲǡp=ǤͲʹͻȌǡ u u ȋFȋͳǡͳͺȌαͷǤ͵ͻǡp=ǤͲ͵ʹǡ²αͲǤʹ͵ȌǤ u ȋFȋͳǡͳͺȌαͳͲǤͲǡp=ǤͲͲͶǡ²αǤ͵Ȍ ȋFȋͳǡͳͺȌαǤͲͶͺǡp=Ǥͺ͵ȌǤ ȋȌ ȋR α ͲǤͳǢ RαͲǤͲͷȌǡ . .
(73) Chapter4. [V]. a) Low SPAI placebo. -4. -2. -2. 0. 0. 2. 2. 4. 4. 6. 6. 8. 8. 10. 10 0. 100. 200. 300. 0. 400 [ms]. Happy approach Happy avoid. c) Low SPAI cortisol. [V]. -2. -2. 0. 0. 2. 2. 4. 4. 6. 6. 8. 8. 100. 200. 300. 400 [ms]. 200. 300. 400 [ms]. d) High SPAI cortisol. [V] -4. 0. 100. Angry approach Angry avoid. -4. 10. b) High SPAI placebo. [V]. -4. 10. P150. 0. 100. 200. 300. 400 [ms]. . Figure4.2. Ǥ ǡ ȋȌ ȋ Ȍ ǡ ȋȌ ȋȌ Ǥ ǡ
(74) ȋ α ͳ͵ͲǤ͵ǡ α ͳͲ ȌǤ Ǥ ǡ ͳͷͲ Ǥ ȋ Ȍ Ǥ. . Ǥ Ǧ u ȋ ǣFȋͳǡͳͺȌα͵ǤʹͶǡp=ǤͲͺͻǢǣFȋͳǡͳͺȌαͲǤͺͷǡp= Ǥ͵ȌǤ ȋFδͲǤͻͳǡp>ͲǤ͵ͶȌǤ ERPresults ͶǤʹ ȋ Ȍ Ǥ P150amplitude ͳͷͲ u ȋFȋͳǡͳͺȌαǤͻǡpαǤͲͳȌǡ ͺ.
(75) Effectsofcortisolinsocialanxiety. . SPAI - social phobia score. 180. 160. 140. 120. 100 R = 0.53, p <.05 80 -2.5. 0.0. 2.5. AA-effect P150 amplitude midline. . Figure4.3. ȋ
(76) Ǧ Ȍ Ǧ ͳͷͲ ȋǤǤ ȏ Ǧ Ȑ ȏ Ǧ ȐȌǤ Ǧ ͳͷͲ ȋ ǡ ǡ Ȍ ǡ Ǥ ͳͷͲ Ǧ ǡ Ǥ. . ͵Ǧ u u ͳ ȋFȋͳǡͳͺȌ α Ǥͻͻǡ p = ǤͲͳǡ²αͲǤʹͺȌǤ Ǧ u ȋFȋͳǡͳͺȌαǤ͵ͻǡp= ǤͲʹͳǡ²αͲǤʹȌ ȋFȋͳǡͳͺȌαͳǤͷʹǡp=Ǥʹ͵ȌǤ
(77) ǡ u ȋFȋͳǡͳͺȌα͵Ǥͻͻǡp=ǤͲͳȌǡ ȋFȋͳǡͳͺȌαͲǤ͵ǡp = ǤͷȌǤ ͵Ǧ ͳͷͲ ǯ Ǥ . ͳ ͳͷͲ ͵ͲͲ ͵ǡ Ͷǡ ͵ǡ Ͷǡ ͵ǡ Ͷ ǡ ȋǡ ǡ Ȍ Ǥ ͳͷͲ ǡ ǤǤ ȋ ȋʹǡ͵Ȍα͵ǤͶʹǡαǤͲͶǡɂαͲǤͻǡɄ;αͲǤͳȌǤ ǡ ȋ ȋͳǡͳͺȌα͵ǤͲǡαǤͲͻȌ ȋ ȋͳǡͳͺȌα ͵Ǥʹ͵ǡαǤͲͺͻȌǤǡ Ǥ. ͻ.
(78) Chapter4. Ǧ ͳͷͲ ȋǤǤǡ ȏͳͷͲ Ǧ Ȑ ȏͳͷͲ Ǧ ȐȌ ȋR α ͲǤͷ͵Ȍǡ Ǧ ͳͷͲ ȋ ͶǤ͵ȌǤ ȋFδʹǤ͵,p>ǤͳͶȌǡ Ǥ ǡ ǡ Ǥ
(79) ǡ ȋR αͲǤͷʹǡp=ǤͲͳͻȌ ȋRαͲǤͳͻǡp=ǤͶʹȌǤ . ͵ͲͲȋFδʹǤͳͶǡp>ǤͳȌǤ. Discussion Ǥ
(80) ȋ Ǥǡ ʹͲͲȌ ȋǤǤǡ Ȍ ȋǤǤǡ ȋͳͷͲȌ ȋ͵ͲͲȌ Ȍ Ǥ ǡ ȋ Ȍ ǡ Ǧ ȋ ǡ Ȍ Ǧ ȋ ǡȌǡ ȋ Ǥǡ ʹͲͲͷǢ Ƭ ǡ ʹͲͲͶǢ ǤǡʹͲͲȌǤ
(81) ȋ Ǥǡ ʹͲͲȌǡ ǡ Ǥ ǡ Ǥ ͺͲ.
(82) Effectsofcortisolinsocialanxiety. ǯ Ǥ ȋ Ȍ Ǥ Ǧ ǡ ǡ ǡ ǤǤǡ ǡ ȋǤǡʹͲͲͻȌǤ Ǥ ǡ ȋͳͷͲȌ ǣ ͳͷͲ Ǥ ͳͷͲ ȋ Ǥǡ ʹͲͲȌǤ ǡ ȋ Ȍ Ǥ ǡ ȋǤǤǡǡʹͲͲͺǢÚƬǡʹͲͲͶǢƬ ǡʹͲͲǢƬ ǡʹͲͲͷȌǤ
(83) ȋȌ Ǧ ǡ ȋǦ Ǥǡ ʹͲͲͷǢ Ƭ ǡʹͲͲʹǢǤǡʹͲͲ͵ǢǤǡʹͲͲȌǤ ǡǦ Ǥ ȋʹͲͲͷȌ ʹ ǡ ȋ Ǥ Ǥǡ ʹͲͲͺǢ ǡ ǡ ǡ Ƭ ǡ ʹͲͲͺȌǤ ǡ Ǥ . ͺͳ.
(84) Chapter4. ȋ Ǥǡ ʹͲͲȌǤ ǡ Ǥ ǡ Ǧ ȋƬ ǡʹͲͲȌǤ
(85) ǡ Ǧ ǡ Ǧ ȋ Ƭ ǡ ʹͲͲȌǤ Ƭ ȋʹͲͲͺȌ ʹͲͲ Ǥ
(86) ǡ ȋ Ǥǡ ʹͲͲȌǡ ͳͷͲ Ǥ ǡ Ǥ
(87) ǡ Ǧ Ǧ ǡ Ǧ Ǥ Ǧ Ǥ ǡǡ Ǥ ǡ ȋ ǤǡʹͲͲȌ ǡ Ǧ Ǥ Ǧ ǡ Ǥ ǡ Ǥ Ǥǡ Ǧ ȋǤǡ. ͺʹ.
GERELATEERDE DOCUMENTEN
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final
ǤͶ ͻǤͷ ͷǤ͵ ͶǤʹ ȋͳǤͺȌ ȋʹǤͷȌ ȋͳǤȌ ȋʹǤʹȌ... AA-effect for
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final