Citation
Rutgers, K. S. (2011, June 30). Development of affinity binders for non- invasive in vivo imaging of neurodegenerative disorders. Retrieved from https://hdl.handle.net/1887/17750
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Development of Affinity BinDers for non-invAsive In VIVo imAging of
neuroDegenerAtive DisorDers
Kim rutgers
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
Development of Affinity BinDers for non-invAsive In VIVo imAging of
neuroDegenerAtive DisorDers
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 30 juni 2011
klokke 13:45 uur
door
Kim sharon rutgers geboren te Nijmegen
in 1975
Prof. Dr. C.T Verrips2
1 Department of Pharmacology, Leiden-Amsterdam Center for Drug Research, Leiden University, Netherlands
2 Department of Molecular Cell Biology, Utrecht University, Utrecht, Netherlands
The studies presented in this thesis were performed at the department of Human Genetics, Neurology, Pathology, Radiology, and Pharmacology at the Leiden University Medical Centre, Leiden, The Netherlands, the department of Molecular Cell Biology, Utrecht University, Utrecht, The Netherlands, the department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, US and the department of Pathology, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, US. This work was financially supported by grants from the IOP Genomics Senter [IGE05005], the National Institutes of Health (NIH AG021084 and AG005134) and by the Centre for Medical Systems Biology within the framework of the Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO).
Publication of this thesis was financially supported the Centre for Medical Systems Biology (CMSB), the J.E. Jurriaanse stichting and Internationale Stichting Alzheimer Onderzoek (ISAO).
In heaven all the interesting people are missing.
(Friedrich Nietzsche)
tABle of contents
Chapter 1 General introduction 9
Chapter 2 Differential recognition of vascular and parenchymal beta
amyloid deposition 27
Chapter 3 Transmigration of beta amyloid specific heavy chain antibody fragments across the in-vitro blood-brain barrier 57 Chapter 4 Binding characteristics and in vivo detection of beta amyloid
deposits using heavy chain antibody fragments
as potential molecular imaging agents 57
Chapter 5 General discussion 81
Addendum Summary 95
Samenvatting 99
Curriculum Vitae 103
Dankwoord 105
