Inouye, M.
Citation
Inouye, M. (2010, April 20). Algorithms and analysis of human disease genomics. Retrieved from https://hdl.handle.net/1887/15277
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral
thesis in the Institutional Repository of the University
of Leiden
ALGORITHMS AND ANALYSIS OF HUMAN DISEASE GENOMICS
Michael Inouye
Colofon
Michael Inouye
Algorithms and analysis of human disease genomics PhD thesis Leiden University, 20 April 2010
Cover credit: Wellcome Images, Wellcome Library, London
Printed by: GVO drukkers & vormgevers B.V. | Ponsen & Looijen, Ede
ISBN: 978-90-6464-386-6
© 2010 Michael Inouye Except (parts of):
Chapter 2: Oxford University Press Chapter 3: Nature Publishing Group Chapter 4: Lancet Publishing Group
ALGORITHMS AND ANALYSIS OF HUMAN DISEASE GENOMICS
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 20 april 2010
klokke 11.15 uur
door
MICHAEL INOUYE geboren te Livingston (USA) in 1981
PROMOTORES
Prof. Dr. Gertjan B. van Ommen
Prof. Dr. Leena Peltonen (Wellcome Trust Sanger Institute)
OVERIGE LEDEN
Prof. Dr. Johan T. den Dunnen
Prof. Dr. Aarno Palotie (Wellcome Trust Sanger Institute) Prof. Dr. Dorret Boomsma (VU Amsterdam)
The studies described in this thesis were performed at the Wellcome Trust Sanger Institute (Cambridge, United Kingdom) and at the Department of Human Genetics of the Leiden University Medical Center (Leiden, The Netherlands).
This work was supported with funding by the Wellcome Trust.
CONTENTS
1. Introduction and aims of the thesis 7
2. A genotype calling algorithm for the Illumina BeadArray platform 22 Bioinformatics. 2007 Oct 15;23(20):2741-6
3. Whole genome-amplified DNA: insights and imputation 29 Nature Methods. 2008 Apr;5(4):279-80
4. Bone mineral density, osteoporosis, and osteoporotic fractures: a 67 genome-wide association study
The Lancet. 2008 May 3;371(9623):1505-12
5. An immune response pathway associated with blood lipid levels 88 Submitted
6. General discussion 118
Summary 125
Nederlandse samenvatting 127
List of publications 129
Curriculum Vitae 132
