• No results found

VU Research Portal

N/A
N/A
Protected

Academic year: 2021

Share "VU Research Portal"

Copied!
37
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)VU Research Portal. Integrative Systems Toxicology for Human Health Sharma, R.P.. 2018. document version Publisher's PDF, also known as Version of record. Link to publication in VU Research Portal. citation for published version (APA) Sharma, R. P. (2018). Integrative Systems Toxicology for Human Health.. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. E-mail address: vuresearchportal.ub@vu.nl. Download date: 14. Oct. 2021.

(2) ÿ ÿ ÿ ÿ ÿ ÿ. ÿ. ÿÿÿÿÿÿ789

(3) ÿÿ. 89 9ÿÿÿÿÿ!ÿ"#2$ÿ%ÿ&'()*+,ÿ)-ÿÿ *.++/ÿ010 ÿ)&(ÿ-)ÿ123*+)(ÿ4ÿ+&ÿ2,3ÿ'(,2)+ÿ52,ÿ,ÿ '2(6(ÿ62))+2,)2+.ÿ&,ÿ2ÿ%),(ÿ7+'2)+ÿ3"8ÿ99:3$ÿ &)2;2#2#23<=32,),+'"#242"#">ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ. 234ÿ.

(4) ÿ ÿ ÿ ÿ ÿ. ÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ ÿ. ÿ ÿ. ÿ. ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ 234ÿ.

(5) ÿ. 0123456ÿ8ÿ. ÿÿÿÿÿ! "ÿ#ÿÿ !$%ÿ&ÿÿ$%ÿ'$ÿ($ÿÿ$)ÿ )$$$ÿÿ. &)%ÿ. *+,+-.ÿ/.012+/ÿ/033+/.ÿ0-24+5/67ÿ8+.67ÿ+9:;/05+ÿ.;ÿ<2/:=+-;7ÿ>ÿ?<@>Aÿ6-1ÿ2./ÿ6//;,26.2;-ÿ B2.=ÿ614+5/+ÿC25.=ÿ;0.,;D+/EÿF/.2D6.2;-ÿ;8ÿ.=+ÿ8+.67ÿ:76/D6ÿ<@>ÿ,;-,+-.56.2;-ÿ85;Dÿ.=+ÿ D6.+5-67ÿ:76/D6ÿ<@>ÿB;071ÿC+ÿ=23=7Gÿ0/+807ÿ.;ÿ:5+12,.ÿ2./ÿ6//;,26.+1ÿ52/Hÿ.;ÿ.=2/ÿ/:+,282,ÿ :;:076.2;-EÿI=+ÿ;CJ+,.24+ÿ;8ÿ,055+-.ÿB;5Hÿ2/ÿ.;ÿ1+4+7;:ÿ6ÿ:5+3-6-,GK:=G/2;7;32,677Gÿ C6/+1ÿ:=65D6,;H2-+.2,ÿ?@L@<@MAÿD;1+7ÿ.;ÿ:5+12,.ÿ.=+ÿ.;92,;H2-+.2,ÿ:5;827+ÿ;8ÿ<@>ÿ2-ÿ.=+ÿ 8+.0/ÿ1052-3ÿ3+/.6.2;-67ÿ35;B.=Nÿ6-1ÿ.;ÿ+46706.+ÿ.=+ÿ1+4+7;:+1ÿD;1+7ÿ0/2-3ÿC2;D;-2.;52-3ÿ 16.6ÿ;C.62-+1ÿ85;Dÿ1288+5+-.ÿ:5+3-6-,Gÿ,;=;5.ÿ/.012+/EÿI;ÿ6,=2+4+ÿ.=2/ÿ;CJ+,.24+Nÿ825/.Nÿ.=+ÿ 6107.ÿ@<@MÿD;1+7ÿB6/ÿ1+4+7;:+1ÿ6-1ÿ467216.+1ÿB2.=ÿ.=+ÿ=0D6-ÿ<@>ÿ.;92,;H2-+.2,ÿ16.6Eÿ I=2/ÿ467216.+1ÿ=0D6-ÿ@<@MÿD;1+7ÿB6/ÿ+9.+-1+1ÿ.;ÿ1+4+7;:ÿ6ÿ@L@<@MÿD;1+7NÿB=2,=ÿ 2-,701+1ÿ.=+ÿ:=G/2;7;32,67ÿ,=6-3+/ÿ1052-3ÿ:5+3-6-,GÿC;.=ÿ2-ÿD;.=+5ÿ6-1ÿ2-ÿ.=+ÿ8+.0/ÿ/0CL D;1+7EÿI=+ÿ1+4+7;:+1ÿD;1+7ÿB;071ÿC+ÿ6C7+ÿ.;ÿ:5+12,.ÿ.=+ÿ<@>ÿ:=65D6,;H2-+.2,/ÿ?@M/Aÿ 2-ÿC;.=ÿD;.=+5ÿ6-1ÿ8+.0/EÿI56-/:76,+-.67ÿ<@>ÿH2-+.2,/ÿ:656D+.+5/ÿ8;5ÿ.=2/ÿ/.01GÿB+5+ÿ .6H+-ÿ85;Dÿ6ÿ:5+42;0/ÿ:5+3-6-.ÿD2,+ÿ/.01GEÿ<;.=ÿ;567ÿ6-1ÿ1+5D67ÿ+9:;/05+ÿ5;0.+/ÿB+5+ÿ 2-,701+1ÿ2-.;ÿ.=+ÿD;1+7ÿ.;ÿ/2D076.+ÿ.;.67ÿ<@>ÿ2-.+5-67ÿ+9:;/05+EÿI=+ÿ2D:6,.ÿ;8ÿ ,;-J036.2;-ÿ6-1ÿ1+,;-J036.2;-ÿ;8ÿ.=+ÿ<@>ÿ6-1ÿ2./ÿD+.6C;72.+/ÿ;-ÿ8+.67ÿ@M/ÿB6/ÿ 2-4+/.236.+1EÿI=+ÿ1+4+7;:+1ÿ@L@<@MÿD;1+7ÿB6/ÿ+46706.+1ÿ6362-/.ÿ.=+ÿ;C/+54+1ÿ<@>ÿ ,;-,+-.56.2;-/ÿ2-ÿ,;51ÿC7;;1Nÿ8+.0/ÿ724+5ÿ6-1ÿ6D-2;.2,ÿ87021ÿ,;-/21+52-3ÿD6.+5-67ÿC7;;1ÿ ,;-,+-.56.2;-ÿ6/ÿ6-ÿ+9:;/05+ÿ/;05,+Eÿ>ÿ56-3+ÿ;8ÿD6.+5-67ÿ+9:;/05+ÿ1;/+ÿ8;5ÿ.=+ÿ;567ÿ6-1ÿ 1+5D67ÿ5;0.+/ÿB6/ÿ+/.2D6.+1Nÿ/;ÿ.=6.ÿ/2D076.2;-ÿ,;-,+-.56.2;-ÿD6.,=+1ÿ.=+ÿ;C/+54+1ÿ =23=+/.ÿ6-1ÿ7;B+/.ÿD;.=+5ÿ:76/D6ÿ,;-,+-.56.2;-ÿ2-ÿ1288+5+-.ÿ,;=;5./Oÿ/.012+/EÿI=+ÿ 1+4+7;:+1ÿD;1+7ÿ,;071ÿC+ÿ0/+1ÿ.;ÿ6115+//ÿ.=+ÿ,;-,+5-/ÿ5+36512-3ÿ:;//2C7+ÿ614+5/+ÿ=+67.=ÿ +88+,./ÿ2-ÿ.=+ÿ8+.0/ÿC+2-3ÿ+9:;/+1ÿ.;ÿ<@>ÿ6-1ÿD23=.ÿC+ÿ0/+807ÿ2-ÿ21+-.28G2-3ÿ,52.2,67ÿ B2-1;B/ÿ;8ÿ+9:;/05+ÿ1052-3ÿ:5+3-6-,GEÿ. P$$%ÿ. QRSTSUVWSXÿZL@<@MÿD;1+7ÿ8;5ÿ<@>ÿ,6-ÿ1+/,52C+ÿ6-1ÿ:5+12,.ÿ.=+ÿ8+.0/ÿ.;92,;H2-+.2,ÿ W[V\]US^ÿ_`^SXÿVaÿbVcdS[e^ÿSfWV^g[Sÿ/,+-652;Eÿ QhVaigj`c]VaL1+,;-J036.2;-ÿ;8ÿ<@>ÿ2-ÿ:76,+-.6ÿ6-1ÿ8+.0/ÿ2/ÿ6ÿH+Gÿ2//0+ÿ8;5ÿ.=+ÿ8+.67ÿ +9:;/05+ÿ.;ÿ:65+-.ÿ<@>Eÿ Qkba]Vc]lÿ\Ug]XÿmZkÿlValSac[`c]Vaÿl`aÿ_Sÿ`ÿjVVXÿ_]Vb`[nS[ÿ\V[ÿ]XSac]\o]ajÿcdSÿl[]c]l`Uÿ B2-1;Bÿ;8ÿ+9:;/05+ÿ2-ÿ8+.0/Eÿ QpSc`UÿSfWV^g[Sÿq`^ÿ,=656,.+52r+1ÿCGÿ6ÿ7;BÿC0.ÿ/0/.62-+1ÿC6/67ÿ<@>ÿ,;-,+-.56.2;-ÿ10+ÿ.;ÿ .=+25ÿ7;BÿD+.6C;72,ÿ6,.242.GEÿ "(%sÿ<2/:=+-;7ÿ>Nÿ@5+3-6-,GL@<@MNÿt+.67ÿ+9:;/05+Nÿ<2;D;-2.;52-3Nÿu2-1;Bÿ;8ÿ +9:;/05+ÿ. ÿ.

(6) ÿ.

(7) ÿ. ÿÿ. 0123456ÿ8ÿ. ÿÿ!"#$%&#ÿ'(ÿ")&!ÿ*ÿ+,,"-ÿ"$-#./&'!ÿ'-#ÿÿ0"$-#ÿ-ÿ1#&ÿ)'!&(/ÿ"0ÿ#&('!/ÿ'-#ÿ -"-2#&('!/ÿ!"#$%(3ÿ45&ÿ#&('!/ÿ"$!%&ÿ-%,$#&ÿ+"(5ÿ%'--&#ÿ'-#ÿ-"-2%'--&#ÿ0""#ÿ 6789:;<=9>ÿ<7@:=@:ÿA<;BÿCB978ÿ7@DÿB978ÿE<;DF68>GHÿCI9:987JK9>ÿ7@DÿI9:987JK9ÿE<;DF68>GHÿ '-#ÿ"(5&!ÿ'%L'M&#ÿ0""#Nÿ'-#ÿ0""#ÿ5'-#,-Mÿ%"-$O&!ÿ!"#$%(ÿ,L&ÿ+'+/ÿ+"((,&Nÿ +&)&!'M&ÿ%"-('-&!ÿ&(%3ÿPQRSNÿ*

(8)

(9) TÿUVWNÿ*

(10) XY3ÿ45&ÿ-"-2#&('!/ÿ"$!%&ÿ-%,$#&ÿ O&#%',ÿ#&)%&Nÿ#&-(',ÿ&','-(Nÿ#$(Nÿ(5&!O',ÿ'&!Nÿ("/ÿ'-#ÿ%"O&(%ÿPZ&-#$Oÿ&(ÿ ',3Nÿ*

(11). TÿUVWNÿ*

(12) XY3ÿ,(5"$M5ÿ-M&("-ÿ"0ÿ(5&ÿÿ0!"Oÿ0""#ÿ"!ÿ1'(&!ÿÿ(5&ÿ !&#"O-'-(ÿ!"$(&ÿ"0ÿ&["$!&ÿP\"!+&!ÿ&(ÿ',3Nÿ*

(13) XYNÿ(5&!&ÿ'!&ÿ"(5&!ÿ-"-2#&('!/ÿ!"$(&Nÿ 15%5ÿ',"ÿ&]$',,/ÿ%"-(!+$(&ÿ("ÿ(5&ÿ("(',ÿÿ&["$!&Nÿ$%5ÿ'ÿ-5','("-ÿ"0ÿ0!&&ÿÿ P%"-%&-(!'("-ÿ-ÿ-#""!ÿ'-#ÿ"$(#""!ÿ'!YNÿ-#!&%(ÿ-M&("-ÿP#$(Nÿ",Nÿ'-#ÿ("/YNÿ'-#ÿ #&!O',ÿ!"$(&ÿP%"-('%(ÿ1(5ÿ(5&!O',ÿ'&!ÿ'-#ÿ' ,%'("-ÿ"0ÿ#&-(',ÿ(!&'(O&-(YÿPZ/!#'Lÿ &(ÿ',3Nÿ*

(14) ^Y3ÿ_&%&-(,/ÿ!&"!(&#ÿ($#&ÿ5')&ÿ0"$-#ÿ!&,'()&,/ÿO"!&ÿ%"-(!+$("-ÿ"0ÿ(5&ÿ #&!O',ÿ!"$(&ÿ("ÿ")&!',,ÿ-(&!-',ÿÿ%"-%&-(!'("-ÿ(5'-ÿ(5&ÿ"!',ÿ!"$(&`ÿ&["$!&ÿ P&#&!O'--ÿ&(ÿ',3Nÿ*

(15)

(16) TÿZ&,L&ÿ&(ÿ',3Nÿ*

(17). Y3ÿa-ÿ'##("-Nÿ!&%&-(ÿ($#&ÿPb&ÿc"&-&,ÿ&(ÿ ',3Nÿ*

(18)

(19) dTÿW$-M$!ÿ&(ÿ',3Nÿ*

(20) eYÿ5"1ÿ(5'(ÿ(&O &!'($!&ÿ5'ÿ'ÿO'f"!ÿO '%(ÿ"-ÿ(5&ÿÿ OM!'("-ÿ,&)&,ÿ-("ÿ1'(&!Tÿ'-ÿ-%!&'&ÿ0!"Oÿe

(21) ÿgcÿ("ÿ^

(22) ÿgcÿ%'-ÿ,&'#ÿ("ÿ'ÿ^h

(23) ÿ0",#ÿ -%!&'&ÿ-ÿ(5&ÿOM!'("-ÿ,&)&,3ÿ ÿ'-#ÿ(ÿO&('+",(&ÿ5')&ÿ+&&-ÿ#&(&%(&#ÿ-ÿO'(&!-',ÿ+,""#Nÿ'O-"(%ÿ0,$#Nÿ0",,%$,'!ÿ 0,$#Nÿ,'%&-(',ÿ($&Nÿ$O+,%',ÿ%"!#ÿ+,""#Nÿ$!-&ÿ'-#ÿ+!&'(ÿO,LÿPW%5i-0&,#&!ÿ&(ÿ',3Nÿ *

(24)

(25) *TÿaL&j$Lÿ&(ÿ',3Nÿ*

(26)

(27) *Tÿk$!"#'ÿ&(ÿ',3Nÿ*

(28)

(29) lTÿk$!$("2m1'ÿ&(ÿ',3Nÿ*

(30)

(31) Tÿ\&&ÿ&(ÿ',3Nÿ*

(32)

(33) nTÿ o5'-Mÿ&(ÿ',3Nÿ*

(34). Nÿ*

(35) lTÿc'"ÿ&(ÿ',3Nÿ*

(36) *TÿZ$-'ÿ&(ÿ',3Nÿ*

(37) lTÿp&!"-'ÿ&(ÿ',3Nÿ*

(38) eTÿ 4&&M$'!#&-ÿ&(ÿ',3Nÿ*

(39) ^Y3ÿa-ÿ#00&!&-(ÿ!"#&-(`ÿ($#&Nÿ(ÿ5'ÿ+&&-ÿ&&-ÿ(5'(ÿ,"1ÿ#"&ÿ"0ÿ +5&-",ÿ&["$!&ÿ#$!-Mÿ(5&ÿM&('("-',ÿ&!"#ÿ5'ÿ&00&%(ÿ"-ÿ(5&ÿ0&!(,(/Nÿ+!'-ÿ #&)&,"O&-(Nÿ'-#ÿ(5&ÿ+&5')"$!',ÿ%5'-M&ÿ-ÿ(5&!ÿ,'(&!ÿ,0&ÿ('M&NÿM-0/ÿÿ ,&"(!"%ÿ&00&%(ÿP','-j'ÿ&(ÿ',3Nÿ*

(40)

(41) *Tÿc'+'("-ÿ&(ÿ',3Nÿ*

(42) lTÿW-f#&!ÿ&(ÿ',3Nÿ*

(43) lTÿR'!,&/ÿ &(ÿ',3Nÿ*

(44) lY3ÿ_$+-ÿ'-#ÿW"("ÿP*

(45)

(46) dYÿ!&)&1&#ÿ(5&ÿ!&-'(',ÿÿ&["$!&ÿ'-#ÿ(ÿ&00&%(ÿ "-ÿ'#"%/(&ÿ#00&!&-('("-Nÿ'ÿO'f"!ÿ%'$&ÿ"0ÿ"+&(/3ÿq3W3ÿU-)!"-O&-(',ÿ!"(&%("-ÿ M&-%/ÿPUYÿ5'ÿ#&%,'!&#ÿ(5&ÿÿ'ÿ'-ÿ&-#"%!-&2O"#0/-Mÿ%5&O%',Nÿ15%5ÿ5'ÿ +&&-ÿ0"$-#ÿ("ÿ+&ÿ!&!"#$%()&Nÿ#&)&,"O&-(',Nÿ/(&O%ÿ("[%'-(Nÿ"+&"M&-%ÿ'-#Nÿ1&'L,/ÿ &(!"M&-%ÿPZ"!/'O'ÿ&(ÿ',3Nÿ*

(47)

(48) *Tÿ_&/ÿ&(ÿ',3Nÿ*

(49)

(50) lTÿ'('$,ÿ&(ÿ',3Nÿ*

(51)

(52) dTÿrÿ&(ÿ',3Nÿ*

(53). Tÿ Q'-Mÿ&(ÿ',3Nÿ*

(54) *Tÿs'0&'#ÿ&(ÿ',3Nÿ*

(55) ^TÿW5'!O'ÿ&(ÿ',3Nÿ*

(56) Y3ÿ #$,(ÿ5$O'-ÿ($#&ÿ5')&ÿ!&"!(&#ÿ(5'(ÿÿ5'ÿ'ÿ)&!/ÿ5"!(ÿ5',02,0&3ÿa(ÿ!'#,/ÿ#&("[0&ÿ ("ÿ-"-("[%ÿ%"-f$M'(&ÿ$+('-%&ÿ$%5ÿ'ÿ2M,$%$!"-#&ÿPpYÿ'-#ÿ2$,0'(&ÿ PWYNÿ%",,&%()&,/ÿ%',,&#ÿ'ÿÿ%"-f$M'(&ÿP2cYNÿ+/ÿM,$%$!"-#'("-ÿ'-#ÿ $,0'("-ÿO&('+",%ÿ!"%&ÿPsi,L&,ÿ&(ÿ',3Nÿ*

(57)

(58) *Tÿ4&&M$'!#&-ÿ&(ÿ',3Nÿ*

(59) XTÿ45'/&!ÿ&(ÿ',3Nÿ *

(60) XY3ÿR"1&)&!Nÿ-ÿ(5&ÿ%'&ÿ"0ÿ(5&ÿ&%0%ÿ"$,'("-ÿ$%5ÿ'ÿ#&)&,"-Mÿ0&($NÿM!"1-Mÿ -0'-(Nÿ'-#ÿ/"$-Mÿ%5,#!&-Nÿ15"&ÿ%5&O%',ÿO&('+",j-Mÿ/(&Oÿ'!&ÿ$-#&!#&)&,"&#Nÿ &)&-ÿO"#&!'(&ÿ&["$!&ÿ%'-ÿ,&'#ÿ("ÿ5M5&!ÿ-(&!-',ÿ%"-%&-(!'("-ÿ"0ÿÿPb)'L'!'-ÿ&(ÿ ',3Nÿ*

(61) eY3ÿZ"!&")&!Nÿ(5&ÿ!&'%()'("-ÿ"0ÿ(5&&ÿ%"-f$M'(&ÿP#&%"-f$M'("-YNÿpÿ'-#ÿ WNÿ+/ÿ(5&ÿ0&(',ÿ($&ÿ'-#ÿ(5&ÿ,'%&-('ÿ5'ÿ+&&-ÿ!&"!(&#ÿPp-+&!Mÿ'-#ÿ_%&Nÿ*

(62)

(63) dTÿ Z$-'ÿ&(ÿ',3Nÿ*

(64) lYNÿ%'$-Mÿ'-ÿ-%!&'&ÿ-ÿÿ-(&!-',ÿ&["$!&ÿ("ÿ(5&ÿ0&($3ÿ45&ÿ!&%&-(ÿ 5$O'-ÿ5'!O'%"L-&(%ÿ($#&ÿ5"1&#ÿ,"1ÿ'O"$-(ÿ"0ÿÿ,'O'ÿ%"-%&-(!'("-ÿ&)&-ÿ 1(5ÿ(5&ÿ5M5ÿ"!',ÿ#"&Nÿ-ÿ%"-(!'(Nÿ&["$!&ÿ'O"$-(ÿ"0ÿÿ0"!ÿ(5&ÿ#00&!&-(ÿ%"5"!(ÿ'!&ÿ &(O'(&#ÿ("ÿ+&ÿ)&!/ÿ,"1ÿ'M'-(ÿ5M5&!ÿÿ ,'O'ÿ%"-%&-(!'("-ÿ"+('-&#ÿ-ÿ +"O"-("!-Mÿ($#&ÿPsi,L&,ÿ&(ÿ',3Nÿ*

(65)

(66) XNÿ*

(67)

(68) *Tÿ4&&M$'!#&-ÿ&(ÿ',3Nÿ*

(69) XTÿ45'/&!ÿ&(ÿ',3Nÿ.

(70) ÿ. ÿ.

(71) ÿ. 0123456ÿ8ÿ.  ÿÿÿ !ÿ" #ÿ$% &ÿ'ÿ%()*ÿ(% %%+ÿÿ%,ÿ -$'.,ÿÿÿ"  ÿ)!ÿ+)ÿ'ÿ%ÿ&$ÿ&) ÿ$%$%)ÿ%,ÿ/01ÿ )+ÿ'ÿ)&ÿ$ÿ&&%$'ÿÿ&'!)%%+$ÿ()ÿ&' $%$ÿ"0/02ÿ %3ÿÿ,%ÿ4ÿ,%ÿ%5ÿ,,$ÿ(5ÿ'ÿ %ÿ&$%ÿÿ'ÿ %()*ÿ(% %%+ÿÿ6')ÿ5ÿ)$&$!ÿ(5ÿ'ÿ&' $%$ÿ %)7ÿ&$%ÿÿ'ÿ(% %%+ÿÿ$%ÿ(ÿÿ%ÿ&'!)%%+$ÿ*%3ÿ +$ÿ&%! %&') )ÿ %+ÿ&%&%)3ÿ8&%)ÿ*%ÿÿ8$)%ÿ%,ÿ%%ÿ %)ÿ%,ÿ8&%)ÿ9%5*3ÿ'ÿ&%))(ÿ$% %ÿ+ÿ) &ÿ$%$%ÿÿ !))ÿ$%ÿ(ÿ%ÿ)%ÿ,%ÿ')ÿ)$&$!ÿ":%+$ÿÿ3ÿ  4;ÿ<ÿÿ3ÿ  4ÿ (ÿÿ)ÿ(!%ÿ'ÿ)$%&ÿ%,ÿ')ÿ&&ÿ=$%ÿ&%! %&') ÿÿ+$%%ÿ >! ÿ)&%)(ÿ,%ÿ'ÿ/01ÿ (%) )ÿ')ÿ(ÿ&%ÿ(!ÿ6ÿ:)ÿÿÿ "  ÿ?ÿ')ÿ(ÿ,%ÿ'ÿ/01ÿ,ÿ ÿ8&%)ÿ')ÿÿ%+ÿ',,ÿ%,ÿ@ÿ'ÿ)ÿ ÿ(!&))ÿ'ÿ,)ÿ&))ÿ (%) 3ÿÿ)ÿ'ÿ)!ÿ)ÿÿ(%%ÿ(!ÿ'ÿA'ÿ!3ÿ 5')ÿ)+ÿ%ÿ%)ÿÿ$% &!ÿ)ÿÿBC@ÿ'ÿÿ*ÿ$'ÿ)!ÿ )ÿ*ÿ5'ÿ!ÿ%)+ÿ"/ ÿÿ3ÿ  ;ÿÿÿ3ÿ . ;ÿÿÿ  !3ÿ  ;ÿ !ÿÿ3ÿ  4ÿ ?ÿ$ÿ!)3ÿ)ÿ%,ÿ&'!)%%+$!ÿ()ÿ&' $%$ÿ"0/02ÿ%+ÿ')ÿ(ÿ Dÿ&%&ÿÿ'ÿ' ÿ''ÿ)ÿ)))) ÿ"E5ÿÿE53ÿ @3ÿ -$'' $'ÿÿ3ÿ  A3ÿ=(+ÿÿ3ÿ  3ÿ=(+ÿÿ3ÿ  B3ÿ-' ÿÿ3ÿ  ÿ 0*%)!3ÿÿ' 3ÿÿÿ%!ÿ0/02ÿ%)ÿ'*ÿ(ÿ*%&ÿ,%ÿ'ÿ/01ÿ ÿ)ÿ$%F+)ÿ"-'ÿÿ3ÿ A;ÿG+%ÿÿ3ÿ #;ÿ=)'ÿÿ3ÿ . ;ÿ<+ÿ ÿ3ÿ  3ÿ  4;ÿ<+ÿÿ=)'3ÿ  ÿ6'ÿ&+$!ÿ&'!)%%+$!()ÿ &' $%$ÿ"00/02ÿ %)ÿ'*ÿ%+ÿ(ÿ)ÿ%ÿ)ÿ'ÿ8&%)ÿ%,ÿ'ÿ $' $ÿ%ÿ'ÿ,)ÿ"E%!ÿÿ3ÿ 4ÿ6'ÿ00/02ÿ%ÿ,%ÿ$ÿ5)ÿ&*%)!ÿ *%&ÿ"25 %%ÿÿ3ÿ  3ÿ5'$'ÿ)'%5ÿ'ÿ&%ÿ8&%)ÿ%,ÿ/01ÿ%ÿ'ÿ ,)ÿ9%5*3ÿÿ00/02ÿ %ÿ,%ÿ'ÿ' ÿ')ÿ%ÿ!ÿ(ÿ*%&ÿ6'ÿ &' $%$ÿÿ,%ÿ$' $)ÿÿ%,ÿÿÿ)&$,$ÿ&%&%)ÿ%,ÿ&+ÿ %'ÿÿ,)3ÿÿ%ÿ'ÿ'$ÿÿ$'$ÿ)%3ÿ5'$'ÿ%,ÿÿ%ÿ,,$)ÿ ÿ(+ÿÿ$ÿ%ÿ9%5*3ÿ'ÿ)ÿ%,ÿÿ&'!)%%+$ÿ()ÿ&' $%$ÿ %ÿ$ÿ)&,!ÿ')ÿ$% &8!3ÿ()ÿ%ÿ)ÿ$&(!ÿ%ÿ&$ÿ'ÿ$)ÿ%,ÿ $' $ÿ*ÿÿ$')$ÿ)+ÿ%,ÿ)ÿ()%&%3ÿ)(%3ÿ(%) )3ÿÿ %ÿ)ÿ'ÿ(%!ÿ6'ÿ%*ÿÿ%,ÿ')ÿ)!ÿ5)ÿ%ÿ&%*ÿ'ÿ )+ÿ%,ÿ'ÿ$' $ÿ%8$%$ÿ%)'&ÿ(5ÿ'ÿ%'ÿÿ'ÿ,)ÿ (!ÿ*%&+ÿÿ00/02ÿ %ÿ,%ÿ'ÿ/01ÿÿ)ÿ$%F+)ÿ6')ÿ5%ÿ(ÿ%ÿ &$ÿ'ÿ,)ÿ&) ÿÿ%+)ÿ/01ÿ$%$%ÿ(!ÿ)+ÿ'ÿ%'ÿ&) ÿ /01ÿ$%$%ÿ3ÿ')ÿ'&)ÿÿ,!+ÿ'ÿ$$ÿ5%5")ÿ%,ÿ8&%)ÿ%ÿ'ÿ ,)ÿ+ÿ)ÿ+)%ÿ&%ÿ%,ÿ*%& ÿ6'ÿ$%$&ÿ %ÿ+ ÿ)ÿ &%*ÿÿ=+ÿ ÿ)'%5+ÿ'ÿ)!ÿ)+ÿÿ,%ÿ')ÿ5%ÿ6'ÿ00/02ÿ%ÿ *%& ÿ')ÿ,%%5ÿ,%%5+ÿ&'))Hÿÿ*%& ÿÿ*%ÿ%,ÿ'ÿÿ 0/02ÿ %3ÿ(ÿ8)%ÿ%,ÿ'ÿ*%&ÿÿ0/02ÿ %ÿ%ÿÿ00/02ÿ5'ÿ'ÿ $)%)ÿ%,ÿ! $ÿ&'!)%%+$ÿ$'+)ÿ+ÿ'ÿ&+$!ÿÿ'ÿ&$%ÿ%,ÿ $' $ÿ%8$%$ÿ&%,ÿÿ(%'ÿ%'ÿÿ,)ÿ$% &ÿÿ$ÿ*%ÿ%,ÿ *%&ÿ00/02ÿ %ÿ+)ÿ'ÿ(% %%+ÿÿ%,ÿ*(ÿ&+ÿ$%'%ÿ &%&%ÿ1ÿ%ÿ$)ÿ)!ÿ%,ÿ')ÿ %ÿ')ÿ(ÿ$!ÿ&()'ÿÿ I>ÿÿÿ"  3ÿ5'ÿ)%ÿ%,ÿ&ÿ/01ÿ8&%)ÿ*ÿ!ÿÿ%,ÿ &+ÿ5% ÿ$ÿ,% ÿ6+%ÿE%!ÿ5)ÿ&,% ÿ. ÿ. ÿ.

(72) ÿ. 0123456ÿ8ÿ. ÿ ÿ ÿÿÿÿÿÿ!ÿÿ"#"$"%ÿÿ&ÿ!!'ÿÿ !ÿÿÿÿ"$"%ÿÿÿ('ÿÿ'ÿÿÿÿ"#"$"%ÿÿ )ÿÿÿÿÿÿ'ÿ'*#ÿ+,ÿ-ÿÿ).ÿ$+&ÿ -ÿ*'ÿ*ÿ(.ÿ+/"ÿ-ÿ'ÿ.ÿ%ÿ-ÿÿÿÿ '*''ÿ0ÿ-ÿ0!.ÿ$ÿ-ÿ*.ÿ*ÿ-ÿ*.ÿ%ÿ-ÿ12.ÿ/ÿ-ÿ'1.ÿ3ÿ-ÿ'ÿ.ÿ4ÿ-ÿ.ÿ 5ÿ-ÿÿ*ÿ).ÿ"ÿ-ÿ.ÿÿ-ÿ'ÿ. ÿ.

(73) ÿ.

(74) ÿ. 0123456ÿ8ÿ. ÿÿÿ!ÿ. "#$#%&'(#)*ÿ&+ÿ*,#ÿ-.-/-0ÿ(&1#%ÿ2#*34)5ÿ#)*42#ÿ+#3*62#ÿ*,3*ÿ65#1ÿ*&ÿ1#57248#5ÿ*,#ÿ316%*ÿ /-9ÿ3)1ÿ/-9.:ÿ;/-9<ÿ3)1ÿ/-9=>ÿ?4)#*475ÿ%4?#ÿ'32*4*4&)ÿ7&#++474#)*ÿ+&2ÿ*,#ÿ&2@3)5Aÿ +237*4&)ÿ6)8&6)1Aÿ(#*38&%45(ÿ;B(3Cÿ3)1ÿ0(>ÿ3)1ÿ#%4(4)3*4&)ÿ;624)32Dÿ#%4(4)3*4&)>EÿF,#ÿ ',D54&%&@473%ÿ7,3)@#5ÿ*,3*ÿ&7762ÿ1624)@ÿ'2#@)3)7Dÿ%4?#ÿ7,3)@#5ÿ4)ÿ'%35(3ÿ$&%6(#Aÿ+3*ÿ $&%6(#Aÿ3)1ÿ3()4&*47ÿ+%641Aÿ'%37#)*3%ÿ3)1ÿ+#*3%ÿ@2&G*,ÿ32#ÿ1#57248#1ÿ35ÿ1D)3(47ÿ '323(#*#25ÿ*,3*ÿ1#'#)1ÿ&)ÿ*,#ÿ@#5*3*4&)3%ÿ'#24&1ÿ;<#)*2Dÿ#*ÿ3%EAÿHII

(75) Jÿ9816%K3%4%ÿ#*ÿ3%EAÿ HI H>Eÿ/#541#5ÿ*,#ÿ&23%ÿ(&1#ÿ&+ÿ#C'&562#Aÿ1#2(3%ÿ(&1#ÿ&+ÿ#C'&562#ÿG35ÿ4)7%61#1ÿ4)ÿ*,#ÿ 1#$#%&'(#)*ÿ&+ÿ*,#ÿ'2#@)3)7D.-/-0ÿ(&1#%EÿF,#ÿ&23%ÿ#C'&562#ÿG35ÿ14$41#1ÿ4)*&ÿ*,2##ÿ #L63%ÿ1&5#5ÿ3)1ÿ1#2(3%ÿ35ÿ3ÿ54)@%#ÿ1&5#Eÿ:&)541#24)@ÿ*,#ÿ@#5*3*4&)3%ÿ@2&G*,ÿ',D54&%&@Dÿ 4)ÿ*,#ÿ735#ÿ&+ÿ*,#ÿ'2#@)3)*ÿ(&*,#2ÿ3)1ÿ+#*65Aÿ*,#ÿ1#$#%&'(#)*ÿ&+ÿ3ÿ-.-/-0ÿ(&1#%ÿ,35ÿ 8##)ÿ1#57248#1ÿ4)ÿ*,#ÿ+&%%&G4)@ÿ5#7*4&)EÿF,#ÿ(&1#%ÿG35ÿ7&1#1ÿ4)ÿ*,#ÿMÿ;$#254&)ÿ

(76) EHE

(77) >Aÿ 3)1ÿ(&1#%ÿ#L63*4&)5ÿ32#ÿ'2&$41#1ÿ4)ÿ*,#ÿ56''%#(#)*32Dÿ(3*#243%ÿ;9))#Cÿ

(78) >Eÿ NÿOÿPQRSRTÿÿUVPVÿ F,#ÿ83547ÿ5*267*62#ÿ&+ÿ*,#ÿ-.-/-0ÿ(&1#%ÿ,35ÿ8##)ÿ313'*#1ÿ+2&(ÿ3)ÿ316%*ÿ(&1#%AÿG,47,ÿ 4)7%61#1ÿ'%35(3Aÿ%4$#2Aÿ?41)#D5Aÿ+3*Aÿ8234)Aÿ5?4)ÿ3)1ÿ3ÿ2#5*ÿ&+ÿ*,#ÿ8&1Dÿ7&('32*(#)*ÿ+&2ÿ *,#ÿ2#(34)4)@ÿ*4556#5EÿF,#ÿ'%37#)*3ÿ3)1ÿ*,#ÿ+#*65ÿ7&('32*(#)*5ÿG#2#ÿ311#1ÿ4)*&ÿ*,#ÿ (&1#%EÿF,#ÿ+#*65ÿ7&('32*(#)*ÿ45ÿ+62*,#2ÿ#C*#)1#1ÿ*&ÿ+#*65ÿ568.(&1#%ÿ7&)541#24)@ÿ%4$#2Aÿ ?41)#DAÿ8234)Aÿ3)1ÿ'%35(3ÿ35ÿ+#*65ÿ568.7&('32*(#)*5EÿF,#ÿ+#*65ÿ568.(&1#%ÿ7&)541#2#1ÿ*,#ÿ +#*65.5'#74+47ÿ(#*38&%47ÿ'2&7#55#5ÿ3)1ÿ4)7%61#1ÿ4('&2*3)*ÿ*32@#*ÿ&2@3)5ÿ+&2ÿ*,#ÿ'2#147*4&)ÿ &+ÿ4)*#2)3%ÿ*32@#*ÿ1&54(#*2DEÿF,#ÿ',D54&%&@473%ÿ3)1ÿ(#*38&%47ÿ'323(#*#25ÿG#2#ÿ3''%4#1ÿ+&2ÿ *,#ÿ+#*65ÿ(&1#%ÿ35ÿ1D)3(47ÿ'323(#*#25ÿ&+ÿ@#5*3*4&)3%ÿ'#24&1ÿ3)1ÿ7,#(473%.5'#74+47ÿ '323(#*#25ÿ567,ÿ35ÿ'32*4*4&)ÿ7&#++474#)*ÿG#2#ÿ?#'*ÿ54(4%32ÿ*&ÿ*,#ÿ316%*ÿ,6(3)ÿ(&1#%ÿ4)ÿ*,#ÿ 735#ÿ&+ÿ8&*,ÿW&*,#2ÿ3)1ÿ+#*65ÿ&2@3)5Eÿ F,#ÿ5&627#ÿ&+ÿ#C'&562#ÿ*&ÿ*,#ÿ+#*65ÿG35ÿ$43ÿ6)8&6)1ÿ7&)7#)*23*4&)ÿ&+ÿ*,#ÿ7,#(473%ÿ4)ÿ*,#ÿ (&*,#2ÿ'%37#)*3Aÿ3556(4)@ÿ&)%Dÿ*,#ÿ(&*,#2ÿ142#7*%Dÿ#C'&5#1ÿ*&ÿ*,#ÿ7,#(473%EÿF,#ÿ '%37#)*3%.+#*3%ÿ6)4*ÿ3556(#5ÿ3ÿ84142#7*4&)3%ÿ*23)5+#2ÿ'2&7#55ÿ1#572484)@ÿ/-9ÿ3)1ÿ/-9.<ÿ *23)5+#2ÿ8#*G##)ÿ(&*,#2ÿ'%37#)*3ÿ*&ÿ+#*65ÿ'%35(3ÿ3)1ÿ$47#ÿ$#253EÿF,#ÿ*23)5+#2ÿ23*#ÿG35ÿ 3556(#1ÿ35ÿ3ÿ54('%#ÿ14++654&)ÿ'2&7#55EÿF23)5'&2*ÿ&+ÿ7,#(473%ÿ+2&(ÿ+#*3%ÿ'%35(3ÿ4)*&ÿ*,#ÿ +#*3%ÿ7&('32*(#)*5ÿ%4?#ÿ%4$#2Aÿ?41)#DAÿ8234)Aÿ3)1ÿ2#5*ÿ&+ÿ*,#ÿ8&1DÿG35ÿ3556(#1ÿ*&ÿ8#ÿ54('%#ÿ 14++654&)ÿ1#57248#1ÿ8Dÿ'32*4*4&)ÿ7&#++474#)*ÿ;53(#ÿ35ÿ&+ÿ(&*,#2ÿ*4556#>EÿF,#ÿ3()4&*47ÿ+%641ÿ 7&('32*(#)*ÿG35ÿ4)7%61#1ÿ4)ÿ*,#ÿ7622#)*ÿ-.-/-0ÿ(&1#%EÿF23)5+#2ÿ23*#5ÿ8#*G##)ÿ*,#ÿ 3()4&*47ÿ+%641ÿ7&('32*(#)*ÿ3)1ÿ*,#ÿ+#*3%ÿ8&1DÿG#2#ÿ1#57248#1ÿ35ÿ3ÿ54('%#ÿ14++654&)ÿ '2&7#55Eÿ F,#ÿ#%4(4)3*4&)ÿ&+ÿ/-9ÿ4)ÿ*,#ÿ(&*,#2ÿG35ÿ3556(#1ÿ*&ÿ8#ÿ54(4%32ÿ*&ÿ316%*ÿ,6(3)AÿG,47,ÿ &77625ÿ$43ÿ4*5ÿ23'41ÿ(#*38&%45(ÿ4)ÿ*,#ÿ%4$#2ÿ3)1ÿ4)*#5*4)#Aÿ5685#L6#)*%Dÿ#C72#*#1ÿ$43ÿ624)#Eÿ X&G#$#2Aÿ*,#ÿ7%#323)7#ÿ&+ÿ/-9ÿ3)1ÿ4*5ÿ7&)K6@3*#5ÿ4)ÿ*,#ÿ+#*65ÿG35ÿ1#57248#1ÿG4*,ÿ+425*ÿ &21#2ÿ*23)5+#2ÿ23*#ÿ+2&(ÿ+#*65ÿ'%35(3ÿ*&ÿ(&*,#2ÿ'%35(3ÿ$43ÿ*,#ÿ'%37#)*3Eÿ ÿOUÿYÿUÿÿ F,#ÿ1D)3(47ÿ',D54&%&@473%ÿ'323(#*#25ÿ+&2ÿ*,#ÿ'2#@)3)*ÿ(&*,#2ÿ*,3*ÿ7,3)@#5ÿ1624)@ÿ*,#ÿ @#5*3*4&)3%ÿ'#24&1ÿ567,ÿ35ÿ'%35(3ÿ$&%6(#Aÿ,#(3*&724*ÿ'#27#)*3@#Aÿ*,#ÿ+#*65ÿ3)1ÿ*,#ÿ. ÿ.

(79) ÿ.

(80) ÿ. 0123456ÿ8ÿ. ÿÿÿÿÿÿÿÿ!"ÿ#ÿ$ÿ%&ÿ%ÿ ÿ'(ÿ%ÿ&ÿÿ'(ÿ&%%ÿÿ(%ÿÿÿ)&ÿ ÿÿ&ÿÿ%ÿÿ#ÿ$ÿ&ÿÿ%*ÿ+%(*ÿ&+%*ÿ'%*ÿÿÿ ÿÿÿÿ'(ÿ+%ÿ&ÿ%&ÿÿÿÿÿ'(ÿ %ÿ,-%&ÿÿ.%&*ÿ //01ÿ!ÿÿ#*ÿ // 2ÿ%ÿ%ÿ$'ÿ3# #ÿ4ÿÿ&ÿ ÿÿ'(ÿÿÿÿÿÿ&ÿ&ÿÿ'(ÿ&'%ÿÿ &ÿÿÿ&ÿÿÿÿÿÿÿ&ÿ'(ÿ%ÿ&%(#ÿ 3%%(*ÿÿ%&ÿ'ÿÿÿÿ&ÿ&ÿ&ÿ+%(*ÿÿÿÿÿ &%ÿÿÿÿ%&ÿ%ÿÿ%ÿÿ,5)4(ÿÿ#*ÿ //61ÿ 7(ÿÿ#*ÿ6880*ÿ68862#ÿ3ÿ(&%%ÿ&ÿÿ&%ÿ&ÿÿ%ÿÿ &%ÿ(ÿÿÿÿ9%&ÿÿÿÿ%ÿ%ÿ&&ÿ ,:%&&ÿÿ#*ÿ /;/1ÿ5)4(ÿÿ#*ÿ //61ÿ7(ÿÿ#*ÿ6880*ÿ68861ÿ,<ÿÿ <*ÿ688=21ÿ3'>%ÿÿ#*ÿ68 62ÿÿÿ%ÿ%ÿ%?@#ÿ $ÿ&ÿÿ&ÿ&'ÿ%Aÿ%ÿ%*ÿ&*ÿ'%*ÿ%%ÿ%ÿÿ &ÿÿÿ'(#ÿ4ÿ'(ÿÿÿÿÿ&ÿÿ'(ÿ&%ÿB9&#ÿ, 2ÿ ÿ,62*ÿ&%(*ÿ&%'ÿ'(ÿ7(ÿÿ#ÿ,68802#ÿ$ÿ9%(ÿÿ%%ÿ%ÿÿ ÿ&%ÿ(ÿ&ÿÿ'(ÿ(%ÿ(%ÿB9#ÿ,02*ÿ&ÿ&%'ÿ'(ÿ 3'>%ÿÿ#ÿ,68 62#ÿ4ÿ'ÿÿ&ÿ%ÿ&ÿÿ%ÿÿÿ'ÿÿ ÿ%&ÿÿÿÿ<ÿÿ#ÿ, ///2#ÿ4&ÿ&ÿ'ÿÿÿÿ%%%ÿ &ÿ&ÿÿ&%ÿB9#ÿ,;2ÿÿ%%&ÿ%%%ÿÿÿÿ%ÿÿ %ÿÿ&ÿ%ÿÿÿÿ'ÿ&ÿÿ&ÿ&*ÿ%ÿ&&ÿÿ'ÿ &ÿ&ÿ*ÿ&ÿ&%'ÿ'(ÿ7(ÿÿ#ÿ,68802#ÿ!ÿ&ÿÿÿÿ&ÿÿ '(ÿ&ÿ%ÿ'(ÿ&'%ÿÿ&ÿÿÿ'ÿ&ÿÿÿÿÿÿÿ ÿÿ%ÿ#ÿ$ÿ(%ÿÿÿÿ&ÿÿ&ÿÿ%ÿ %&ÿ&%ÿÿ&%ÿB9#ÿ, 2#ÿ$ÿ&ÿÿÿ%ÿ'(ÿ!ÿÿ#ÿ , // 2ÿÿ@<Cÿ,68862ÿÿ&ÿÿÿÿ&ÿÿ%ÿ&ÿÿ&ÿ %ÿÿ%&ÿ'(ÿ%ÿ%ÿ%&ÿ(%ÿÿ&%'ÿ%ÿB9#ÿ, 2#ÿ$&ÿÿ &ÿÿÿ&ÿ&%ÿ'(ÿ%(%ÿÿ'(ÿÿ%ÿ&ÿ %ÿÿÿÿ&ÿ&%'ÿ%ÿB9#ÿ,

(81) 2#ÿ $ÿ&*ÿ*ÿÿ%%ÿ%ÿÿ+%%&ÿÿÿ'(ÿ(%ÿÿ %ÿ9%&Dÿ EFGHIJKLMNOPPQRSTUMVWXOYZWRMSTUMV[OXPSV\RM]^R_\````aÿNOZZNR ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿSTUMVW\YOWPZRMSTUMVPOYWSV\RM_\R]^````ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ, 2ÿÿÿÿÿÿÿÿÿ EFcdefHgIeÿLYOZ[ÿRÿMSTUhVQO\N\RSTUMV[O_NSV\RM]^_\```iÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ,62ÿ ÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ EjklmlnolpGdJqrLWOQX\ZRstuvwVWO_Y[XRstuvwxaYO_YX\RstuvwyVÿYOYYXWR ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿM]^zP`{\aÿYOYYYY[ÿRÿM]^zP`{[ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ,02ÿ |*ÿ}~&ÿÿÿÿ&ÿ&ÿÿ%ÿÿ&%ÿ(ÿ%ÿ€*ÿ7-ÿÿ&%ÿ (*ÿ}~ÿÿÿÿÿ%ÿ€*ÿÿ}~%%%ÿ%ÿÿÿÿ%%%ÿ %ÿ%ÿ€#ÿÿ $ÿ'ÿÿÿÿ&ÿÿ&ÿÿ'(ÿ&%ÿÿ%ÿÿ9%Dÿ. ÿ.

(82) ÿ.

(83) ÿ. 0123456ÿ8ÿ. ÿ !"#$% ÿÿÿÿ ÿ ÿ ÿ ÿÿÿÿÿÿÿ&'(   ÿÿÿÿÿÿÿ ÿ  ÿÿ ÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ )*+,+-ÿ./01234567ÿÿ9ÿ:*+ÿ;<==>ÿ?<=@ÿ:=ÿ=,ABCÿDCÿE-ÿF.0/12GH5I4Jÿ9ÿK=CL:BC:ÿ?,BK:D=Cÿ =?ÿKB,>DBKÿ;<==>ÿ?<=@ÿ:=ÿ=,ABCÿDCÿM=:*+,-ÿBC>ÿNOP1QR134567ÿ9ÿ:*+ÿ?+:SLÿKB,>DBKÿ=S:TS:Uÿ V*+ÿ=,ABCÿW=<SM+ÿ=?ÿ:*+ÿ?+:SLÿ@BLÿLKB<+>ÿ;XÿSLDCAÿ:*+ÿ?=<<=@DCAÿA+C+,B<ÿ+YSB:D=CZÿ [./01234567F./01234567 [\ÿ]^_`Qÿÿÿÿÿ ÿ ÿ ÿ ÿÿÿÿÿÿÿ&

(84) ( ÿÿ ÿ ÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ ÿ )*+,+-ÿ[./01234567ÿ9ÿ:*+ÿ=,ABCÿW=<SM+ÿDCÿE-ÿF./01234567ÿ9ÿK=CL:BC:ÿ?,BK:D=Cÿ=?ÿ=,ABCÿ =?ÿ?+:SLÿBLÿBÿ?SCKD:=Cÿ=?ÿA+L:B:D=CB<ÿ>BX-ÿBC>ÿ[\]^_`Qÿ9ÿ:*+ÿ:=:B<ÿW=<SM+ÿ=?ÿ?+:SLÿBLÿBÿ ?SCK:D=Cÿ=?ÿA+L:B:D=CB<ÿ>BXUÿ a<<ÿ:*+ÿT*XLD=<=ADKB<ÿTB,BM+:+,LÿB,+ÿT,=WD>+>ÿDCÿ:*+ÿBCC+bÿcÿ&VB;<+ÿaU (UÿV*+ÿ>XCBMDKÿ A,=@:*ÿT,+ACBCKXÿT*XLD=<=AXÿ+YSB:D=CLÿB,+ÿ:Bd+Cÿ?,=MÿT,+WD=SLÿL:S>D+Lÿ&e+C:,Xÿ+:ÿB<U-ÿ fggchÿa;>S<iB<D<ÿ+:ÿB<U-ÿfg f(ÿLSMMB,Dj+>ÿDCÿVB;<+ÿ Uÿ VB;<+ÿ UÿkB,BM+:+,DjB:D=Cÿ=?ÿT,+ACBC:ÿM=:*+,ÿBC>ÿ?+:SLÿT*XLD=<=AXÿ l=:*+,ÿVDLLS+ÿW=<SM+ÿ EDW+,ÿW=<SM+ÿ;ÿ m\nopqrst uvoowÿÿÿÿ xD>C+Xÿy=<SM+ÿ;ÿ m\zo{q|}s~€ uvoowÿÿ eS:ÿW=<SM+;ÿ m\‚wƒ uvoowÿÿ „,BDCÿy=<SM+;ÿ m\uo †s uvoowÿÿ k<BLMBÿW=<SM+ÿKÿ m‡ˆ††‰ÿŠ‹•ŒŽ‹ŠŠ‘‹’Š “Ž ‹” – uvÿÿ —CD:DB<ÿ?B:ÿW=<SM+Bÿ m\wssuv˜ow †ÿÿ ™B:ÿW=<SM+ÿÿBÿ m\ ‹žžwÿ uv˜ow ‰†‘‹š q›œ“‹žŸ ¡“ ›ž ž ¢  ¢ q £ Š’–ÿÿ ¤¥VKÿ ¦!“§ÿÿš‹¨Ž‹Œ’’ ‰ ”–Ž‹Š¨ ‰ ”–ÿÿ k<BK+C:Bÿy=<SM+Bÿ m\"#©qwÿÿ‹ªŒ «q›‹¬•¬­®‹¯°±­²³´ ¯²µÿÿ. ÿ.

(85) ÿ.

(86) 0123456ÿ8ÿ. ÿ. ÿÿÿÿÿ $%&$%'(')*+ÿ-./01-./023245*-6789:;()9ÿ ÿ ÿÿ!ÿÿ *-6<;)=>*-6?@'('A)':ÿ<8='Bÿ ÿÿ"ÿ#"ÿ !ÿÿ ÿ#!ÿ ÿ C!ÿ!ÿD#! ÿ C!ÿD#! ÿÿ C#ÿ# ÿD#! ÿÿ_ÿ C!ÿ#DÿD#! ÿÿ_ÿ C!ÿoÿD#! ÿÿ_ÿ C!ÿ_ÿD#! ÿÿ_ÿ x ÿ#!ÿD#! ÿ. -6<;)=>&EFGGHIJ;KLMFNOIPQRFSTIUQVIWXIYVZ *J;KL[NF\OIPQTF]^IUQVIYVIWXZÿ ÿ. -`a/bc/dU4ef &g`a/bc/dU4I-hP0ibÿ. -68'j;k6<;)=>&galmPnhP0I-6<;)=>ÿ -6p'B(;q6<;)=>&grlstPuhP0I-6<;)=>ÿ -6vk9'(6<;)=>&gwn/lthP0I-6<;)=>ÿ -6?@'('A)':ÿ<8='B &y*zFH{|}I~?1zFy€{ I~?[*yFy{|I~?‚ƒ1yFyy{z I~? *yFyyyy€I~?ÿ C!ÿÿÿ_ÿD#! ÿ -6k;>)vABq6<;)=>ÿ &„yFHI-6<;)=> 1„-6†89>@96<;)=> *-68'j;k6<;)=>*-6p'B(;q6<;)=> *-6vk9'(6<;)=> ÿ #ÿ#ÿÿÿ!ÿ‡ˆ‰Šÿ #ÿ ÿ!!ÿÿ ‹Œ6$8AAB6'(')&‹ŒŒI$%'(')„F\ƒ ÿ ÿ _ _#ÿÿ x!ÿ #ÿ ÿ_ÿ ‹Œ6†89>@96'(')&‹Œltl0I„z1ŽŒ ÿ !!ÿÿ# ÿ# ÿ # ÿ#ÿÿ#Dÿ_ÿ # ÿ#ÿÿ!ÿ_ÿ. ÿ. ‹6‘'j;k&g6‹‘'j;kIÿ‹Œ6†89>@96'(')ÿ ‹6~=)&g6‹~=)Iÿ‹Œ6†89>@96'(')ÿ.

(87) ÿ.

(88) ÿ. G ÿ%$-ÿ$ÿ% ÿÿÿ Z# !!ÿ%$-ÿ$ÿ#ÿ% ÿ ÿ '$$ÿ%$-ÿ$ÿD  ÿ & " ÿ%$-ÿ$ÿD  ÿ r ÿD " ÿ%$-ÿ Z  ÿ$*D*ÿ. 0123456ÿ8ÿ HIJKLMNMOPJIHJKLQÿHSITUKVWKIXYXLÿ HIJKLPHIJKLMNMOQ[\]\^]O^O bÿ _`_a. HITUKcdYLKIeUffgPhijhQ\IkUKcdYLKÿ HITUKcdYLKÿPHITUKcdYLKIeUffgQlmnopSqÿ HsXgYdtÿPhuvwjxxmxQyzn{j{ui|Qyz}ÿ HSPHSIXYXLvlHIJKLnHIlJKLIXYXLÿqÿq vlHsXgYdtÿnHsXgYdtIXYLÿq vÿÿÿHTUKcdYLKÿ. '$$ÿ%$-ÿ$ÿ%*ÿ~#ÿ Z  ÿ$*D*ÿ%$ÿÿ HSeUffgI€dLVPJH€dLVQ\ITUKVWKI€dLVÿ %*ÿ F ÿ   ÿ $*D*ÿ HkUKVWKI€dLVPHSI‚UffgI€dLVQlÿmnoSpƒ„O †qÿ +*ÿ$ÿD " ÿ F ÿEÿ$$ÿ%$-ÿÿ H‡Xˆd‰Iÿ€dLVPJH‡Xˆd‰QHSITUKVWK€dLVÿ F ÿ.ÿ$$ÿ%$-ÿÿ HsXgdYtIÿ€dLVPJHsXgYdtQHSITUKVWK€dLVÿ F ÿ ÿ$$ÿ%$-ÿÿ H‚‰KXYIÿ€dLVPJH‚‰KXYQHSITUKVWK€dLVÿ ÿ ÿÿÿÿ ÿÿÿÿÿ  ÿ !ÿ"#$ÿ%$ÿ&'&(ÿÿÿ)*+ ÿÿ ÿ  ÿ ,ÿ $ ÿ ÿ)ÿÿ $ ÿ !ÿÿ-.ÿ ÿ /010ÿ345ÿ6789:8;<=>?@A>;Bÿ C#ÿ$D* ÿ#" ÿ# ÿÿD$Eÿÿ#ÿF!ÿÿ#$-!ÿ*$ÿ$%ÿ'&)ÿ ÿ ÿ" $ÿÿ#ÿ$ÿ ÿ. ÿ. ÿ.

(89) ÿ. 0123456ÿ8ÿ. ÿ ÿÿÿÿÿ!"#ÿ$ÿÿ%&ÿÿ'ÿÿ$ÿ&ÿÿ (()(ÿ&ÿ&ÿÿ'$(ÿÿÿÿ!"#ÿ$ÿ!"#)*ÿ $'ÿÿ$'&ÿÿ!"#ÿ$ÿÿ'(ÿÿÿ$ÿ&ÿ'$+ÿ ,ÿÿÿ")"!"-ÿ$(ÿÿ!"#.ÿ+((ÿÿ$&ÿ+ÿ/ÿ (&$$ÿ0'(ÿÿ+ÿ/ÿ$&$ÿ1ÿ(ÿÿÿ)1ÿ23ÿÿ (&&$ÿ$ÿ&(.ÿ$ÿÿ)+ÿ'$+ÿ/ÿÿ!"#ÿ '(ÿ$ÿÿÿ&ÿ/ÿ($ÿ&ÿ&ÿ)1ÿ$ÿ$ÿ&ÿ(ÿ ÿ.ÿ$.ÿ/ÿ&ÿ(1ÿ$ÿ'$+ÿ/ÿ/ÿ'(ÿÿ ÿ(+ÿ23ÿ43&ÿÿÿ5ÿ$ÿ-ÿ4 +ÿÿÿ&'ÿ ÿÿ6+5.ÿÿÿ$ÿ&.ÿÿÿÿ)1ÿ&$ÿ$ÿÿ'ÿ($ÿ ÿ)11ÿÿÿ$ÿÿ1$$ÿÿÿ3ÿ7ÿ4'(ÿ#5ÿ 89:9;9ÿ=>?@ÿABC?DEÿ?FGÿHACÿIEC?JK@LMIÿ N((+.ÿÿ(ÿÿÿ!"#ÿ&ÿ$ÿÿ$$ÿÿÿ%ÿ&ÿÿ 3&ÿ4OPQ.ÿR R5ÿ,ÿÿ$(+ÿ''$ÿ&ÿÿ&ÿ$ÿ3&ÿ ÿÿÿ'($ÿ1ÿÿRST ÿÿU&$ÿ1ÿ/ÿÿ(ÿ '1('(+ÿÿ!"#ÿÿ1+ÿ(/.ÿÿÿÿ&ÿÿÿ'(.ÿÿÿ ÿ$ÿ(1.ÿ'ÿ((+ÿ''$ÿÿÿ&ÿ42V((ÿÿ(.ÿRRW.ÿRRXÿ 0(ÿ$ÿN&$)Y+.ÿR 5ÿ !ÿ!"#ÿ$ÿ!"#Nÿ&ÿÿÿ&ÿÿÿ+ÿ/ÿ$'$ÿ'+ÿÿ$ÿ .ÿ$ÿÿ+ÿ$(+ÿÿ!"#ÿ1(ÿÿÿ&ÿ4-%Z1ÿÿ(.ÿ RR 5ÿÿ(ÿ'ÿÿÿÿ!"#ÿ/ÿ6$ÿÿÿ[ÿÿ(ÿ4R W5ÿ $ÿÿ$ÿÿ&ÿÿ!"#Nÿÿÿÿÿÿ(1ÿ/ÿÿÿÿ 1&ÿ&$+ÿÿ[ÿ$ÿÿ4R W5ÿ 0ÿÿÿ(ÿ$$ÿ!"#ÿ'(6ÿÿ!"#Nÿ'+ÿ(ÿ\]"Nÿ406&ÿ ÿ(.ÿR RXÿ$ÿ^&ÿÿ(.ÿR 5ÿÿ)1ÿ)11ÿ3(ÿ4,2,2_5ÿ ÿ$ÿ&ÿ'(ÿÿ4_`ÿ4a55ÿ/ÿ($ÿÿ$'ÿ!"#ÿ (&&$ÿÿÿÿÿ4*&'ÿÿ(.ÿRRbXÿ[ÿÿ(.ÿR S5ÿÿ(ÿ ÿ)1ÿ23ÿÿÿ)11ÿ4,2,2_5ÿ/ÿ$ÿ(+ÿ_`ÿ4 5ÿÿ&$ÿ (ÿÿÿÿÿ&ÿ$ÿ/ÿÿ&ÿÿÿ'$+ÿ/ÿÿ ÿ(ÿÿ23.ÿÿ&ÿÿ(ÿÿÿÿ&ÿÿ7ÿcÿ40""NN5ÿ. ÿ.

(90) ÿ.

(91) ÿ. 0123456ÿ8ÿ. ÿÿÿÿÿÿÿÿÿÿ!ÿÿÿ""ÿ#$ÿÿ %!&'ÿ( )*+ÿ ,ÿ-!ÿ!ÿ!"&ÿÿ!ÿÿ--ÿ./ÿ 01234789:;<=>?@AB<CDÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿÿÿÿÿÿÿ#L* 56 E9F=GHI:J<CDÿ ÿ ÿÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ 6ÿ M&'ÿÿ5N9O Pÿÿÿÿ-!ÿQ&"ÿÿ'ÿRSÿPÿÿSÿ 56 ÿ -!ÿ&'ÿTÿPÿÿ""&ÿÿ!!&ÿ&.&ÿÿÿ)ÿQ&"ÿÿ!ÿ RS'ÿU&ÿPÿÿ""&ÿÿ!!&ÿÿ&ÿ-!ÿ&'ÿÿÿPÿ &"-ÿ+ÿÿ RSÿ!ÿ!"-ÿÿVWWÿQ&ÿÿXMÿ&ÿVW&ÿ"--ÿ-ÿ!!ÿÿ!ÿÿ --ÿ/ÿ YZ[\]^_`ab`^_ac7]YZ[\defd4gh<ijjkk<Ylm`cnopqrsÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ# *ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ ÿÿ ÿ ÿ ÿ ÿ ÿ M&'ÿYZ[\ ÿPÿVW&ÿW-ÿÿ-"ÿ"Q"ÿÿQ&ÿ&ÿÿ"&!-ÿ Q&ÿ#!def-dÿ4"gh--ÿ-*ÿ'ÿijjkkÿPÿ"&!-ÿQ&ÿQ&ÿ&ÿÿÿ'ÿRÿPÿ-ÿ ÿÿÿ&'ÿÿXMÿPÿÿ-ÿÿÿÿ+ÿ tuvutuÿxyz{|}ÿ|~€z‚ƒ€„ÿ|„ ÿ{y‚|~€}ƒ{ÿ †"-ÿQ-!ÿQQ&!ÿ&!ÿÿ!!ÿÿ&!ÿÿX‡ˆÿSQ!&ÿWÿÿ &-ÿ&ÿWÿÿX‡ˆÿQ&!"ÿÿ&-!ÿÿ&.-ÿ"!ÿÿ""ÿÿ ÿÿ!ÿ#X&ÿÿ-+'ÿ( ‰ÿŠ!!ÿÿ-+'ÿ(. ‰ÿ‹ÿÿ-+'ÿ(. *+ÿŒV W&ÿW-ÿ!ÿ"-&ÿ-ÿSQ&!ÿ!ÿÿÿ!ÿ!ÿQ-ÿÿ!&ÿ ÿ-ÿX‡ˆÿÿX‡ˆŽÿÿX‡ˆÿ#T&ÿÿ-+'ÿ(‰ÿ‘-ÿÿ-+'ÿ(. *+ÿ †"-'ÿ‹-ÿÿ-+ÿ#(. *ÿQ-!ÿ&-ÿ!&ÿ-ÿÿX‡ˆÿ"Q&ÿ&-ÿ &ÿÿ

(92) ’ÿ!&Qÿ&'ÿÿ&-ÿ&ÿ"!&ÿ&ÿ&Q&ÿ !&Qÿ&!ÿ!"ÿ!ÿ ÿ#“”'ÿ(*'ÿ ÿ#‹&"ÿÿ-+'ÿ( *'ÿ•Lÿ#‘-ÿÿ-+'ÿ(. *'ÿ ÿLÿ#X&ÿÿ-+'ÿ( *ÿÿ!ÿQ&"ÿÿÿ&-ÿ!&Qÿ&ÿÿ !ÿÿX‡ˆÿ&-ÿSQ!&ÿ-W-+ÿ ŒÿÿQ&!ÿ!'ÿÿ&-ÿ&ÿÿSQ!&ÿ!ÿ"!&ÿ&ÿÿW-Qÿÿ ‡V‡X‡Tÿ-+ÿU!&ÿÿ"ÿÿÿW&ÿÿÿ!&Qÿ&ÿÿX‡ˆÿWÿ !'ÿ!ÿ&Q&ÿQ&-ÿ""ÿ#!ÿPÿ+()ÿ *'ÿÿ&ÿÿ-ÿ-ÿ Q&Wÿÿ‹-ÿÿ-+ÿ#(. *ÿ!ÿ!ÿÿW-Qÿÿ‡V‡X‡Tÿ-+ÿ,ÿ--ÿ “.+ÿ#*ÿ!ÿQQ-ÿ&ÿ"-"-ÿ!ÿ!&Q/ÿ 0 ž ÿ¦]˜[™™ b–^_ÿœ§b–^_n 04b–^_7—b–^_<]˜™š[bZ[<›mœ˜b–^_<Ÿ ¡¢de ÿ£¤¥¡2¥cÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ¨ b–^_ ÿ©aª^§šac<` «›ÿ<–[b<¬n­®®®ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ#* ÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ ÿÿ M&'ÿ¯!ÿPÿÿ"&"ÿ-ÿ-ÿÿ!'ÿUQ-!ÿPÿÿQ-!ÿ""-ÿ ""&'ÿÿPÿÿ&"-ÿ'ÿT°!°ÿQ-!ÿPÿÿQ-!ÿ!ÿQ&ÿ.

(93) ÿ. ÿ.

(94) ÿ. 0123456ÿ8ÿ. ÿÿÿÿÿÿÿ!ÿÿÿÿ"ÿÿ ÿÿÿÿ!ÿÿÿÿ!!ÿ#ÿ$ÿÿÿ$ÿ ÿÿÿÿÿÿ!ÿ%ÿÿÿ&ÿÿÿÿ!ÿ 'ÿÿÿ"ÿÿÿÿÿÿ!&%ÿÿ(ÿ )*+*+*ÿ-./0123456ÿ47ÿ/8.ÿ09:3/ÿ34;.<ÿ =>??ÿ@""ÿÿÿÿ!AÿB%ÿÿ"!ÿÿ!ÿÿ"@ÿ C(ÿDÿ"@ÿA"@ÿÿ@""ÿÿÿÿ!ÿÿÿ %%ÿÿÿ@%ÿÿÿ&ÿ!@%ÿ$ÿEFÿÿ (ÿ GGH&I(ÿJ='ÿ"@ÿÿ!&!ÿÿ!ÿ@""ÿÿ"ÿ A"@ÿÿÿ$ÿ&%ÿ">>K"ÿÿELM=KDIÿÿ "ÿEFLNDIÿO%!ÿ$%ÿE#!ÿÿ(ÿP

(95)

(96) QRÿSÿÿ(ÿP

(97)

(98) Rÿ Sÿÿ(ÿP

(99). I(ÿDÿÿ$"ÿÿT!Cÿÿ#!ÿÿ@""ÿ!ÿ ÿÿ$ÿ"ÿBÿ$&%ÿÿ@""ÿEU&%ÿÿ(ÿP

(100)

(101) Rÿ#"ÿ ÿFÿP

(102)

(103) HRÿ#"&%ÿÿ(ÿP

(104)

(105) RÿVO"ÿÿ(ÿP

(106)

(107) RÿDÿN"ÿÿ(ÿP

(108) PI(ÿ ?ÿÿÿ"%ÿÿÿÿÿÿ&ÿ@""ÿÿ"ÿÿÿ =J=#ÿ!ÿBÿ$ÿ&%ÿ?T?TUÿ@ÿ(ÿDÿ" ÿÿ>$ÿÿ ÿÿBÿ"ÿÿ$@ÿ!C!"!ÿÿ$%ÿE"@ÿÿ(ÿP

(109) PIÿ"@ÿ UW(ÿEGIÿÿ"ÿ!!ÿÿ$"ÿEQPÿ!@X@ÿÿ$Iÿÿ$ÿB@ÿEP(Yÿ @ÿÿJZI(ÿDÿ!&!ÿBÿ&ÿ&ÿÿV>VÿW"ÿ "@ÿUW(ÿEYIÿÿ!!ÿÿÿ" ÿ=J=#ÿ!(ÿDÿÿ"&"ÿÿÿ !!ÿBÿÿ"ÿÿÿÿ"ÿÿÿÿ$$ÿ$"(ÿ [\]^_`abcdef_[\]^ghigjklmnoopqm[`abcderstuvwÿÿÿÿÿÿÿÿÿÿÿÿ ÿ ÿÿÿÿÿÿÿEGIÿÿÿÿÿÿÿÿÿÿÿÿ ÿ ÿÿÿÿ ÿ ÿÿ Zÿ[\]^ ÿÿ>$ÿ$"ÿÿ!&ÿ%ÿÿÿ@!ÿÿ!!ÿ ÿEghiÿgjklÿIÿnoopqÿÿÿ!!ÿÿÿ@!ÿÿN$ÿT$ÿÿ ÿÿ$ÿB@ÿÿ@!ÿÿJZÿÿBÿ&%ÿB@ÿÿ@ÿÿ )*+*y*ÿz{|ÿ6./0123456ÿ47ÿ/8.ÿ8:607ÿ}./03ÿ34;.<ÿ ~!ÿÿÿ@""ÿA"@ÿ$$ÿB@ÿÿ"ÿÿÿÿ"%ÿ ÿ"&ÿE!ÿÿ&ÿA"@Iÿÿÿÿ!ÿÿ"%ÿÿÿ> "&ÿ((ÿ@""ÿÿÿÿCÿÿÿÿ$%ÿÿÿO%!ÿ &ÿÿ@""ÿ((ÿ">>K"ÿÿELM=> €‚ƒÿ€ †ÿ‡ˆ‰‡†‰Š‹ŒŠˆ‰ÿŽˆ‘’“”ÿ•†Šÿ•†” Š‚ÿˆ–ÿ—˜™š‡—›ÿ•†‹†ÿœƒžÿŸÿ  ƒ¡ÿŽ–†ŠŒ‘ÿ $IÿQ

(110) ÿ¢ÿ. GÿE"ÿ$Iÿ H( ÿ¢ÿ ( ÿE!>!ÿIÿÿ H(

(111) ÿ¢ÿ (HÿEÿ!ÿ IÿEJÿÿ(ÿ GH Rÿÿÿ(ÿP

(112)

(113)

(114) Rÿ"@ÿÿ(ÿ G Rÿ#Bÿÿ £ÿ G I(ÿDÿ&$ÿÿBÿÿÿLM=KNL'ÿÿÿÿÿ"!ÿÿ $ÿÿÿ¤>ÿBÿÿÿÿÿ"ÿ$(ÿ'ÿ"%ÿÿBÿÿ ÿ$%ÿÿLM=KDÿBÿ"ÿÿÿ%ÿ@ÿÿÿ"ÿB@ÿ@""ÿÿ ÿÿ!@ÿÿÿÿ"!ÿ"ÿEF&"@ÿÿ(ÿP

(115)

(116) PI(ÿDÿCÿÿ ÿBÿ!ÿLKDPJ ¤ÿÿPJHÿÿ&ÿÿ"!ÿÿ$ÿ"@ÿÿ ÿ!ÿÿ@%ÿÿÿ&ÿÿÿ"ÿÿ ¥ÿÿÿ$"ÿ "ÿÿ"ÿEM$ÿÿ(ÿP

(117) ¦I(ÿ. ÿ.

(118) ÿ.

(119) ÿ. 0123456ÿ8ÿ. ÿÿÿÿÿÿÿ!"ÿÿÿ#ÿ$ÿÿÿÿ %ÿ&ÿÿÿ'#(ÿÿÿÿÿÿÿ)ÿÿ*ÿÿ*ÿ*ÿ+ÿ ÿ%ÿ,-../0%ÿ1$)ÿ+ÿ#ÿÿÿ(ÿ)ÿÿ'#(ÿÿÿÿ 2#ÿ)ÿÿÿÿÿÿÿ)ÿÿÿÿ#%ÿ3ÿÿÿ #ÿÿ4ÿÿÿ#*#ÿÿÿÿ)ÿ$ÿÿÿ#ÿÿÿ )ÿÿÿÿÿ)#ÿÿÿÿ%ÿ&ÿÿ ##ÿÿÿÿ#ÿÿÿ)ÿÿÿÿÿ56--ÿÿ$7ÿ $ÿ .6 8ÿ#ÿ,!7ÿ 59/0ÿÿ-8ÿ#ÿ,!7ÿÿ%ÿ 59/0ÿÿ$ÿÿÿ ÿÿÿÿÿ-8ÿ#:ÿ)ÿ$ÿ7ÿ#*ÿÿÿ)ÿÿÿ #ÿÿÿ$ÿÿ#*ÿÿÿ#%ÿ&ÿ)ÿ$ÿÿÿ ÿ$ÿ)ÿÿÿ#ÿ#ÿ$ÿ$ÿÿ*ÿ7ÿÿÿ )ÿÿ)ÿ#ÿ ;<!ÿ,-..-0ÿÿ,)ÿÿÿ(ÿ&*ÿ"% 0ÿÿÿ #ÿ$ÿ$ÿÿ*ÿ,#ÿ=ÿÿÿÿÿÿÿ 0%ÿ&ÿÿÿ##ÿÿÿÿ#ÿ)ÿ$ÿ#ÿÿ*ÿ ÿÿÿÿ%ÿ&ÿÿÿÿÿÿ)ÿ 2#ÿ)ÿ$ÿÿÿÿÿÿ)ÿÿ*ÿ$%ÿ&ÿÿ'#(ÿ)ÿ ÿ$ÿÿ%ÿ&ÿ'#(ÿ#(##ÿ)ÿÿÿ!"ÿÿÿ ÿ)ÿ$ÿ)ÿ*ÿÿ$ÿ=>ÿ ?@ABCDEFGHI?@ABJKLJEMNOPQQRSCDEFGO?TUVWXCDEFGYZ[\]^W_`abcdÿÿÿÿÿÿÿÿÿÿÿÿÿÿ, .0ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ ÿ ÿÿÿ eÿ?@ABCDEFGÿÿfÿ#(##ÿ#*#ÿÿÿÿ)ÿ?@ABJKLJEMNÿfÿÿ g)ÿ#*#ÿÿPQQRSCDEFGÿfÿ##ÿÿÿ#ÿÿÿ)ÿÿ ?TUVWXCDEFGÿfÿ)ÿ)#ÿÿ%ÿ hijikiÿmnopqrqstuvwxyvtuÿvuÿznyq{ÿrt|}xsy|nuyÿ ~g+ÿÿÿ2#ÿ$ÿÿÿÿÿ(*ÿ ,€7ÿÿ%ÿ 5590%ÿ&ÿÿ)ÿÿÿÿ‚ƒ„ÿ‚†ÿ‡ˆ„ÿ~g+ÿÿ ÿÿÿÿÿÿÿ*ÿ$ÿÿÿÿÿÿÿ7ÿ #%ÿ ÿÿ#ÿÿ)#ÿÿÿÿ*ÿÿÿ ÿ)ÿÿ#ÿÿÿÿÿ)#ÿÿ ,‰ÿÿ%ÿ 5Š5‹ÿŒÿÿ€$ÿ 5990%ÿ ÿÿÿÿ#ÿÿÿ ÿ)ÿÿÿÿÿ,;*ÿÿ%ÿ-. 0%ÿŽ#27ÿ ÿ%ÿ,-../0ÿÿÿÿÿÿÿÿÿÿ$ÿÿ )ÿÿŠŠ/ÿ#::#‰€!ÿÿÿÿÿ--ÿ$7ÿ$ÿÿ#ÿÿ ÿÿÿ%ÿ‰)ÿÿÿ)ÿÿ!"ÿÿÿ ‡ˆ„ÿƒ‘„’‡ÿ’“ÿ†„‡”•ÿ•ˆ‚–„“ÿ‡ˆ‡ÿ~ÿ—ƒ”‘”‚’˜“•„ÿ˜•ÿ„•„’‡ÿ‡ÿÿÿÿ ÿÿÿ)ÿÿÿÿÿ,+*ÿÿ<ÿ-..50%ÿ hi™iÿšnyt}pxrnuyxpÿ›œÿžvunyvr{ÿ !ÿÿÿÿ*ÿÿ(*ÿÿÿ#ÿÿÿÿÿÿ ÿ#ÿ*ÿ(ÿÿ#%ÿ‰7ÿÿ%ÿ,-. .0ÿÿÿ(ÿ))ÿÿÿ ÿ$ÿÿ!"ÿÿÿÿÿ#ÿ%ÿ3ÿ7$7ÿÿ %ÿ,-. -0ÿÿÿÿÿÿÿÿ!"ÿÿÿÿÿÿ *%ÿ&ÿÿÿÿ!"ÿÿÿ#ÿÿ#ÿ*#ÿ,€Ÿÿÿ. ÿ. ÿ.

(120) ÿ. 0123456ÿ8ÿ. ÿ

(121) 

(122) ÿÿÿÿ

(123) 

(124) ÿÿÿÿ

(125) ÿÿÿÿ

(126)  ÿ!"#$ÿÿÿ

(127)  %ÿ &"'ÿ(#)ÿ*ÿ#&*ÿ*ÿ+,-ÿ"$"ÿ"ÿ.)#ÿ#ÿ)#&ÿ(/ÿ'ÿ(ÿ*ÿ +,-0ÿ#ÿ"ÿ*&ÿ'&ÿ*#ÿ12#ÿÿÿ

(128)  ÿ0#ÿÿÿ

(129)  3%ÿ&&4#$ÿÿÿ "ÿ$)##ÿ#ÿ5"ÿ.)#ÿ#ÿ*&ÿ(ÿ12#ÿÿÿ

(130)  ÿ0#ÿÿÿ

(131)  3%ÿ#ÿ*)ÿ6&"'ÿÿÿ1

(132)  %ÿ#ÿ.*&#ÿ7.4#&ÿ&"'ÿ"ÿ&4ÿ 4#ÿ*ÿ+,-0ÿ&ÿ#&*ÿÿ"ÿ*&ÿ)&&ÿ"ÿ.)#ÿ&"'#$ÿ(/ÿ'ÿ 5)#ÿ#&*ÿ*ÿ+,-0ÿ 8"ÿ4"ÿ.&4ÿ#ÿ.)#ÿ.#ÿ)**)#ÿ(ÿ*ÿ+,-ÿ#ÿ+,-0ÿ'ÿ #ÿ*4ÿÿ.(&ÿ&/ÿ*ÿ9&#:/ÿÿÿ1

(133) 

(134) %ÿ#ÿ'4ÿÿÿ1

(135) ;%ÿ &.)(/ÿ#ÿ"&ÿ4ÿ&5#ÿ*ÿ&*#ÿ)#<$ÿ*ÿ+,-ÿ1+,-=%ÿÿ"ÿ*&ÿ )4.4#ÿ'&ÿ#ÿ)#&ÿÿÿ)ÿ*ÿÿ#ÿ.)#ÿ#&*ÿ8"ÿ#&*ÿ ÿ)#&#&ÿ*ÿ+,-0ÿ#ÿ"&ÿ4ÿ'ÿ#ÿ*4ÿ"ÿ.$##ÿ4)ÿ,+,ÿ4ÿ #ÿ&)ÿÿ*ÿ5/ÿ'$"ÿ1'4ÿÿÿ

(136) ;%ÿ&ÿ"ÿ&ÿ#ÿ(5ÿ"4#ÿ ÿ-#/ÿ"ÿ$)##ÿ*ÿ+,-ÿ#ÿ.)#ÿ'&ÿ&)5ÿ)#&#$ÿ >47ÿ#ÿ4ÿ(ÿ*4ÿ#ÿ#?(ÿ".)ÿ)ÿ#ÿ19$"#ÿÿÿ

(137) 

(138) %ÿ8"ÿ#?((ÿ >47ÿ*ÿ"ÿ.)#ÿ'&ÿ))ÿ&#$ÿ.)#ÿ4)&4ÿ)##ÿÿ. ÿ4$@$ÿ 12)$"#ÿÿÿ

Referenties

GERELATEERDE DOCUMENTEN

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition