University of Groningen On the role of macrophages, microglia and the extracellular matrix in remyelination Wang, Peng

(1)

University of Groningen

On the role of macrophages, microglia and the extracellular matrix in remyelination

Wang, Peng

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Wang, P. (2018). On the role of macrophages, microglia and the extracellular matrix in remyelination.

University of Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the

author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately

and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the

number of authors shown on this cover page is limited to 10 maximum.

(2)

517533-L-sub02-st-Peng

Processed on: 27-2-2018

Stellingen behorende bij het proefschrift

On the role of macrophages, microglia and the extracellular matrix in remyelination van Peng Wang (2018)

1. Since multiple remyelination-inhibitory ECM proteins are present in MS lesions, it is essential to examine whether counteracting the effect of one, will overcome remyelination failure (Lau et al., Annals of Neurology, 2012, Qin et al., Journal of Neuroscience, 2017, this thesis)

2. To appreciate the role of alternatively activated microglia/macrophages in supporting remyelination, it should be addressed which strategy i.e., nursing of OPC differentiation or modulating inflammation or both, offers the most favorable environment for remyelination to occur. (Miron et al., 2013, Nature Neuroscience, 16, 1211-1218; Psachoulia et al., 2016, Brain, 139, 3121-3136.)

3. Microglia change activation along with regions and stages of multiple sclerosis, while macrophages like cells are derived from different sources in active multiple sclerosis lesions. However, whether these different activation stages of microglia/macrophages possess different function, such as remodeling ECM or expression of MMPs according to time and different ECM targets, should be further studied. (Zrzavy T. et al., 2017, Brain, 140, 1900-1913.).

4. Although the role of MMPs has been implicated in demyelination in MS, it is too premature to conclude that reducing MMP activity may cure MS (Lukes et al., 1999, Molecular Neurobiology, 19, 267-84.)

5. Although all the ‘omics’ approaches have revolutionized disease research, including MS, biochemical analysis of structural protein variants will be indispensable in resolving pathophysiological factors of a disease. (Stoffels et al., 2013, Brain, 136:116-31; Back et al., 2005, Nature Medicine, 11, 966-72.)

# 6. The gentleman aims at harmony, and not at uniformity. The mean man aims at uniformity, and not at harmony. (Kong Zi). 君子和而不同，小人同而不和. (孔子).

A single flower does not make a spring, while one hundred flowers in full blossom bring spring to the garden. (一花独放不是春,百花齐放春满园).