University of Groningen
On the role of macrophages, microglia and the extracellular matrix in remyelination
Wang, Peng
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2018
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Wang, P. (2018). On the role of macrophages, microglia and the extracellular matrix in remyelination.
University of Groningen.
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aFn: fibronectin aggregatesAldh1L1: aldehyde dehydrogenase 1, member L1 APMA: 4-aminophenylmercuric acetate BMDMs: bone marrow-derived macrophages BrdU: 5-bromo-2-deoxyuridine
(c)aMS: chronic active
CCNs: cysteine-rich angiogenic proteins CD206: cluster of Differentiation 206 (mannose receptor)
CD40: cluster of differentiation 40 cFn: cellular fibronectin
(c)iMS: chronic inactive MS lesions CNS: central nervous system CSF: cerebrospinal fluid
CSPGs: chrondroitin sulfate proteoglycans CWM: control white matter
CXCL-12: chemokine (C-X-C motif) ligand-12 DOC: deoxycholate
DPL: days post lesion
EAE: experimental allergic encephalomyelitis ECM: extracellular matrix
FGF-2: fibroblast growth factor-2 GAGs: glycosaminoglycans
GAPDH: glyceraldehyde 3-phosphate dehydrogenase GFAP: glial fibrillary acidic protein
HBMS: hydroxymethylbilane synthase HLA-DR: human Leukocyte Antigen–antigen D Related
HMW-hyaluronan: high molecular weight hyaluronan Hsp: heat shock protein
IB4: isolectin-B4
Iba1: ionized calcium-binding adaptor molecule-1 IFN: interferon gamma
IGF-1: insulin-like growth factor-1 IL-1: interleukin-1 beta IL-10: interleukin-10 IL-4: interleukin-4
iNOS: inducible nitric oxide synthase LDH: lactate dehydrogenase LFB: luxol fast blue
LMW-hyaluronan: low molecular weight hyaluronan LPS: lipopolysaccharide
MBP: myelin basic protein
M-CSF: macrophage colony-stimulating factor MMPs: matrix metalloproteinases MS: multiple sclerosis
MTT:3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazol ium bromide
NAWM: normal appearing white matter NF: neurofilament
NGS: normal goat serum NO: nitric oxide
OFSCs: organotypic forebrain slice cultures OPCs: oligodendrocyte progenitor cells PBS:phosphate-Buffered Saline PDGF: platelet-derived growth factor PDGF: platelet-derived growth factor PFA: paraformaldehyde
pFn: plasma bovine fibronectin PLL: poly-L-lysine
Poly (I:C): polyinosinic:polycytidylic acid rMS: remyelinated MS lesion
RT-qPCR: real-time quantitative polymerase chain reaction reaction
SPARCs: secreted protein acidic and rich in cysteine SVZ: subventricular zone
TGF: transforming growth factor beta
TIMPs: tissue inhibitors of matrix metalloproteinases TLR: Toll-like receptor
TME: Theiler’s murine encephalomyelitis TNF: tumor necrosis factor-α
t-PA: tissue-type plasminogen activator TSP1: thrombospondin-1
