Cover Page
The handle http://hdl.handle.net/1887/70039 holds various files of this Leiden University
dissertation.
Author: Ouweneel, A.B.
Cholesterol metabolism and hematopoiesis
interaction in atherothrombosis
Printing, layout and cover design: Optima Grafische Communicatie ISBN: 978-94-6361-234-0
Ouweneel, Amber
Cholesterol metabolism and hematopoiesis interaction in atherothrombosis Proefschrift Leiden
Met literatuur-opgave – met samenvatting in het Nederlands © 2019 Amber B. Ouweneel
Cholesterol metabolism and hematopoiesis
interaction in atherothrombosis
Proefschrift Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College van Promoties te verdedigen op donderdag 21 maart 2019 klokke 15.00 uur
door
Amber Berlinde Ouweneel geboren te Gouda
Promotor: Prof. Dr. M. van Eck Copromotor: Dr. B.J.M. van Vlijmen
Promotiecommissie: Prof. Dr. H. Irth (LACDR) (voorzitter) Prof. Dr. J.A. Bouwstra (LACDR) (secretaris) Overige commissieleden: Prof. Dr. H.H Versteeg (LUMC)
Prof. Dr. N. Zelcer (AMC) Prof. Dr. G. Pasterkamp (UMCU)
The research described in this thesis was performed at the Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands. The work described in this thesis was funded by Leiden University, and in part supported by a VICI grant 91813603 from the Netherlands Organization for Scientific Research and the Landsteiner Foundation for Blood Transfusion Research (#0912).
Financial support by the Dutch Heart Foundation for publication of this thesis is grate-fully acknowledged.
Table of conTenTs
chapter 1 General introduction 9
chapter 2 Lipoproteins as modulators of atherothrombosis: From endothelial function to primary and secondary coagulation
31 Vascular Pharmacology. 2016; 82:1-10
chapter 3 Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice
61 Atherosclerosis. (in press)
chapter 4 Cholesterol efflux transporters ABCA1 and ABCG1 differentially influence megakaryopoiesis and proplatelet production
79 Manuscript in preparation.
chapter 5 Apolipoprotein A1 modulates the ability of bone marrow to facilitate lymphocyte production after transplantation into LDL receptor knockout mice
95
Submitted for publication.
chapter 6 Vulnerable plaque and vulnerable blood: two critical factors for spontaneous atherothrombosis in mouse models
117 Submitted for publication.
chapter 7 Silencing of anticoagulant protein C evokes low-incident but spontaneous atherothrombosis in apolipoprotein E-Deficient mice
129
chapter 8 Predilection of low protein C-induced spontaneous
atherothrombosis for the right coronary sinus in apolipoprotein E deficient mice
143
Scientific Reports. 2018;8(1):15106.
chapter 9 Scavenger receptor BI is required for our previously published lipid nanoparticle-based siRNA approach for in vivo protein C silencing in mice
173
Submitted for publication.
chapter 10 General discussion and future perspectives 179
Nederlandse samenvatting 195
Scientific publications 207
PhD portfolio 209
