University of Groningen
Molecular fluorescence imaging facilitating clinical decision making in the treatment of solid
cancers
Koller, Marjory
DOI:10.33612/diss.99700036
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Publication date: 2019
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Koller, M. (2019). Molecular fluorescence imaging facilitating clinical decision making in the treatment of solid cancers. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.99700036
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Marjory Koller
Molecular fluorescence imaging facilitating clinical
decision making in the treatment of solid cancers
Koller, Marjory
Molecular fluorescence imaging facilitating clinical decision making in the treatment of solid cancers
ISBN: 978-94-034-2103-2
ISBN electronic version: 978-94-034-2102-5 Printed by: GVO drukkers & vormgevers B.V. Lay-out: Mascha van Kempen
The printing of this thesis was financially supported by SurgVision B.V., LiCor Biosciences Inc., TRACER B.V., Nedap Healthcare, Universitair Medisch Centrum Groningen, Graduate School of Medical Sciences, NoordNegentig and Chipsoft.
© 2019, M. Koller, Groningen, The Netherlands. All rights reserved. No part of this thesis may be reproduced, stored in retrieval systems, or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the author or, when appropriate, of the publisher of the published articles.
Molecular fluorescence imaging facilitating clinical
decision making in the treatment of solid cancers
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 13 november 2019 om 11.00 uur
door
Marjory Koller geboren op 30 maart 1988
Promotor
Prof. dr. G.M. van Dam Copromotor
Dr. W.B. Nagengast Beoordelingscommissie Prof. dr. P.J. van Diest Prof. dr. J.M. Klaase Prof. dr. C. Rosman
Paranimfen R.A. Alingh A.L. Koster
CONTENTS
Chapter 1 General introduction and outline of the thesis 7
Chapter 2 Implementation and benchmarking of a novel analytical 15 framework to clinically evaluate tumor-specific fluorescent tracers
Nature Communications, 2018
Chapter 3 Molecular fluorescence-guided surgery of peritoneal 51 carcinomatosis of colorectal origin: a single-centre feasibility study Lancet Gastroenterology and Hepatology, 2016
Chapter 4 Back-table fluorescence-guided imaging for evaluation of 73 circumferential resection margins in patients with locally
advanced rectal cancer using bevacizumab-800CW
Accepted for publication in Journal of Nuclear Medicine, 2019
Chapter 5 Quantitative fluorescence endoscopy improves evaluation of 97 neoadjuvant treatment response in locally advanced rectal cancer Published as short report in Gut, 2019
Chapter 6 Data-Driven Prioritization and Review of Targets for 121 Molecular-Based Theranostic Approaches in Pancreatic Cancer
Journal of Nuclear Medicine, 2017
Chapter 7 Summary and future perspectives 149
Chapter 8 Nederlandse samenvatting (Dutch summary) 159
Appendix Curriculum Vitae 169
List of Publications 171
