University of Groningen
Clinical application of near infrared fluorescence imaging in solid cancers Voskuil, Floris
DOI:
10.33612/diss.151946702
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Voskuil, F. (2021). Clinical application of near infrared fluorescence imaging in solid cancers: Enhancing surgical accuracy by lighting up tumors. University of Groningen. https://doi.org/10.33612/diss.151946702
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Stellingen behorende bij het proefschrift:
Clinical application of near infrared fluorescence imaging in solid cancers
Improving surgical accuracy by lighting up tumors
1. Intra-operative margin assessment using fluorescent imaging agents enables the possibility for an immediate re-excision in case of a tumor-positive resection margin, which might decrease second surgery rates or post-operative adjuvant therapy. (this thesis)
2. Ex vivo imaging of the surgical specimen, followed by subsequent in vivo surgical cavity imaging, is a preferable imaging strategy for intra-operative margin assessment. (this thesis)
3. Tumor-type agnostic imaging agents exploiting tumor acidosis will expand the clinical applicability of fluorescence-guided surgery in a multitude of solid tumors. (this thesis)
4. A standardized imaging methodology, including in- with ex vivo correlation, is
recommended for performing an early phase clinical study, and facilitates rapid go/no-go decisions for clinical applicable fluorescent imaging agents. (this thesis)
5. Fluorescence molecular endoscopy might serve a red-flag imaging technique to guide the endoscopist in clinical decision-making. (this thesis)
6. Smart-activatable imaging agents might serve as proof-of-concept for future smart-activatable therapeutic compounds. (this thesis)
7. In vivo fluorescence imaging might serve as a tool to detect additional unexpected tumor lesions during surgery within the patient, whereas ex vivo fluorescence imaging can assist the surgeon and pathologist for the detection of additional tumor lesions within the specimen. (this thesis)
8. Anyone can have a good day, but you have to be able to perform on a bad day. (Jürgen
Klopp)
9. Nothing in life that’s worth anything is easy. (Barack Obama)
10. Het leven is mieters! (Bikko Voskuil)
