University of Groningen Clinical application of near infrared fluorescence imaging in solid cancers Voskuil, Floris

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University of Groningen

Clinical application of near infrared fluorescence imaging in solid cancers

Voskuil, Floris

DOI:

10.33612/diss.151946702

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Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Voskuil, F. (2021). Clinical application of near infrared fluorescence imaging in solid cancers: Enhancing surgical accuracy by lighting up tumors. University of Groningen. https://doi.org/10.33612/diss.151946702

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551403-L-bw-Voskuil 551403-L-bw-Voskuil 551403-L-bw-Voskuil 551403-L-bw-Voskuil Processed on: 11-12-2020 Processed on: 11-12-2020 Processed on: 11-12-2020

Processed on: 11-12-2020 PDF page: 177PDF page: 177PDF page: 177PDF page: 177

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his Atheneum’s degree at the OSG Sevenwolden, Heerenveen.

During his study Medicine at the University of Groningen, Floris was actively involved in several extracurricular organizing committees. After obtaining his Bachelor’s degree, Floris performed his Master’s research thesis at the Brigham and Women’s Hospital, Harvard Medical School, Boston, USA, where he investigated the role of an anti-cancer drug on the vascular endothelium under supervision of prof. Garcia-Cardeña. Once returned, he performed his clinical internships at the Wilhelmina Hospital, Assen and the Isala Hospital, Zwolle. Here, the interest in surgical oncology started. During his internships, Floris was the president of the Master’s student council. In 2017, after doing his fi nal internships at the departments of Surgery and Plastic Surgery in the Martini Hospital, Groningen, he fi nished his Master’s degree. He graduated with distinction. Supervised by dr. M.J.H. Witjes, prof. dr. G.M. van Dam and prof. dr. W.B. Nagengast, Floris started as PhD-candidate, investigating optical imaging techniques for the enhanced detection of solid tumors at the University Medical Center Groningen. Floris presented his study results at several international congresses and was awarded with the ‘Young Investigator Award Finalist’ and the ‘BOOA research grant’ among others.

Currently, Floris is obtaining his Doctor of Dental Surgery degree at the University of Groningen, after which he will start with his residency in Oral & Maxillofacial Surgery at the University Medical Center Groningen. Floris lives together with Hedi Koning and they recently moved into their fi rst own house.

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2014

R. Oberhuber, T. Heinbokel H. Rodriguez, .., .., F.J. Voskuil, et al. Aged CD11c+ Dendritic cells communicate an accelerated rejection of older organs through an IL-17A dependent alloimmune response. Circulation. 2015

F.J. Voskuil, P.K.C. Jonker, G.M. van Dam, M.J.H. Witjes. Aankondiging klinische trial: A non- randomized, non-blinded, phase 1-2 diagnostic study of cetuximab-IRDye800CW for margin assessment in image guided surgery of head and neck squamous cell carcinoma. Nederlands

Tijdschrift voor Oncologie. 2017

F.J. Voskuil*, S.J. de Jongh*, W.T.R. Hooghiemstra M.D. Linssen et al. Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study. Theranostics. 2020

F.J. Voskuil*, S.J. de Jongh*, I. Schmidt, A Karrenbeld, et al. C-Met targeted fl uorescence molecular endoscopy in Barrett’s esophagus patients and identifi cation of outcome parameters for phase-I studies. Theranostics. 2020

S.J. de Jongh*, J.P.M. Vrouwe*, F.J. Voskuil, I. Schmidt, et al. The optimal imaging window for dysplastic colorectal polyp detection using c-Met targeted fl uorescence molecular endoscopy.

Journal of Nuclear Medicine. 2020

J. Vonk*, J.G. de Wit*, F.J. Voskuil, M.J.H. Witjes. Improving oral cavity cancer diagnosis and treatment with fl uorescence molecular imaging. Oral Dis. 2020

F.J. Voskuil, S.J. de Jongh, S.A.H.J. de Visscher, K.P. Schepman, et al. Fluorescentie geleide beeldvorming voor snijvlak evaluatie in hoofd-halskanker patiënten gebruikmakend van cetuximab- 800CW: Een kwantitatieve dosis escalatie studie. Nederlands Tijdschrift voor

Oncologie. 2020

F.J. Voskuil*, P.J. Steinkamp*, T. Zhao, B. van der Vegt, et al. Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fl uorescence-guided surgery.

Nature Communications. 2020

P.J. Steinkamp*, B.K. Pranger*, M.F. Li, ..., F.J. Voskuil, et al. Fluorescence-guided visualization of soft- tissue sarcomas by targeting vascular endothelial growth factor-A: a phase 1 single-center clinical trial. Journal of Nuclear Medicine. 2020

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F.J. Voskuil*, J. Vonk*, B. van der Vegt, S. Kruijff, et al. The Current Status and Future Perspectives of Intraoperative Imaging Assisted Pathology, an Uncharted Application in Precision Surgical Oncology. Accepted in Nature Biomedical Engineering.

F.J. Voskuil*, P.J. Steinkamp*, B. van der Vegt, J.J. Doff, et al. Improving and standardizing real-time margin assessment in head and neck cancer using a tumor acidosis sensitive optical imaging agent. Submitted to Oral Onocology.

J.G. de Wit*, J. Vonk*, ..., F.J. Voskuil, M.J.H. Witjes. Targeted fluorescence imaging for postoperative selection of at-risk lymph nodes in patients with head and neck cancer. Submitted to Theranostics.

F.J. Voskuil*, P.J. Steinkamp*, B. van der Vegt, J.J. Doff, et al. Fluorescentie-geleide chirurgie bij verschillende soorten solide tumoren middels een pH-geactiveerde fluorescente tracer. Under revision at Nederlands Tijdschrift voor Heelkunde.

*Both authors contributed equally and therefore share first authorship. Appendix 1

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