Changes in chromatin organization of human cells in response to genotoxic stress Abdel-Halim Mahfouz, H.I.

Changes in chromatin organization of human cells in response to genotoxic stress

Abdel-Halim Mahfouz, H.I.

Citation

Abdel-Halim Mahfouz, H. I. (2009, February 24). Changes in chromatin organization of human cells in response to genotoxic stress. Retrieved from https://hdl.handle.net/1887/13517

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

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Arabic Summary

ϰΑήόϟ΍ κΨϠϤϟ΍

Arabic summary

Αήόϟ΍ κΨϠϤϟ΍

ϰ

ϥ·

ϰϠϋ ΔψϓΎΤϤϟ΍

Δϣϼγ Πϟ΍

˰ ϳϼΧ ϰϓ ϡϮϨϴ

˰ Ϧ΋ΎϜϟ΍ Ύ ϰΤϟ΍

έϭήο ήϣ΃

ϯ ήϴΒόΘϠϟ ϨϴΠϟ΍

ϰ

΢ϴΤμϟ΍

Ϻϟϭ ΎϘΘϧ ϞϣΎϜϟ΍ ϝ

Ϸ΍ ϰϟ· ΔϴΛ΍έϮϟ΍ ΕΎϣϮϠόϤϠϟ ϝΎϴΟ

ΔϣΩΎϘϟ΍

ΎϣϭΩ ΕΎϨ΋ΎϜϟ΍ νήόΘΗ ϦϜϟϭ . ϰΘϟ΍ Ϟϣ΍ϮόϠϟ

ΓΩΎϤϟ΍ ϰϠϋ ΎΒϠγ ήΛΆΗ

ΔϴΛ΍έϮϟ΍

΃ ϥ Ω) ΎϳϼΨϟ΍ ΔϳϮϧ΃ ϞΧ΍Ω( Ϸ΍ Φδϧ ϞΜϣ ΔϣΎϫ ΕΎϴϠϤϋ ϞϴτόΗ ϰϟ΍ ϯΩΆϳ ΎϤϣ

ϤΣ ΔϳϭϮϨϟ΍ νΎ ϩάϫ Ϧϣ.

ΌϴΒϟ΍ ϰϓ Ϧ΋ΎϜϟ΍ Ϫϟ νήόΘϳ Ύϣ Ϟϣ΍Ϯόϟ΍

˰ Ψϟ΍ Δ Ύ Ϩϣϭ ΔϔϠΘΨϤϟ΍ Δϴ΋ΎϴϤϴϜϟ΍ Ω΍ϮϤϟ΍ϭ ωΎόηϹ΍ ϞΜϣ ΔϴΟέ ϞΧ΍Ω ϥϮϜΘϳ Ύϣ ΎϬ

όϟ΍ ΔΠϴΘϧ ϢδΠϟ΍

ΔϳϮϴΤϟ΍ ΕΎϴϠϤ ΔϴΛ΍έϮϟ΍ ΓΩΎϤϟΎΑ ΓέΎπϟ΍ Ε΍ήϴΛ΄Θϟ΍ ΔϴϠΨϟ΍ ϡϭΎϘΗ ϰϜϟϭ .

ΕΎϴϟ΁ ΪΟϮΗ ΡϼλϹ

΃ ϥ Ω ϯϭϮϨϟ΍ ξϣΎΤϟ΍ ΕΎΌϳΰΟ ϟ΍ ϚϠΗ ΎϬΒΒδΗ ϰΘϟ΍ Ε΍ήϔτϟ΍ Ϧϣ ΔϴϠΨϟ΍ ϰϤΤΗ

Ϟϣ΍Ϯό ϰϓ ΍έϮμϗ ΙϭΪΣ ΪϨϋϭ ˬ

ΕΎϫϮθΘϟ΍ ΞΘϨΗ ΕΎϴϟϵ΍ ϩάϫ Ε΍Ϋϭάθϟ΍ ϭ΃

ΔϴϧΎσήδϟ΍ ν΍ήϣϷ΍ϭ ΔϴϣϮγϮϣϭήϜϟ΍

.

ϟ΍ ϦϴΗΎϣϭήϜϟ΍ ΔϧϮϜϣ ΕΎϨϴΗϭήΒϟ΍ Ϧϣ ΔϔϠΘΨϣ ω΍Ϯϧ΍ ϊϣ ΪΤΘΗ ΔϴΛ΍έϮϟ΍ ΓΩΎϤϟ΍ ϥ΃ ΎϴϤϠϋ ϑϭήόϤϟ΍ Ϧϣϭ ϞϜθΘϳ ϯά

ΎόΒΗ ϦϴΗΎϣϭήϛϭήϴΘϴϫ ϭ ϦϴΗΎϣϭήϛϮϳ ΎϤϫ Ϧϴϴδϴ΋έ ϦϴϋϮϧ ϰϟ΍

ΔϓΎΜϜϟ ϑΎϔΘϟϻ ΍ ϰϓ ΎϤϬϨϣ Ϟϛ ϭ. ΕΎγ΍έΪϟ΍ ΖΘΒΛ΍ Ϊϗ

ϥ΍ ΔΜϳΪΤϟ΍

έ΍ήοϻ΍

ϦϴΗΎϣϭήϜϟ΍ ΐϴΗήΗϭ ΐϴϛήΗ ϰϓ Ε΍ήϴϴϐΗ ϰϟ΍ Ύπϳ΍ ϯΩΆΗ ΔϴΛ΍έϮϟ΍ ΓΩΎϤϟΎΑ ΙΪΤΗ ϰΘϟ΍

ϞΧ΍Ω

Γ΍ϮϨϟ΍

ϦϴΗΎϣϭήϜϟ΍ ϰϠϋ ΃ήτΗ ϰΘϟ΍ Ε΍ήϴϴϐΘϟ΍ ΪϳΪΤΗ ϰϟ΍ Δγ΍έΪϟ΍ ϩάϫ ϑΪϬΗ . ΔϠΣήϣϭ ΔϴϨϴΒϟ΍ ΔϠΣήϤϟ΍ Ϧϣ Ϟϛ ϰϓ

ϯίϮΘϴϤϟ΍ ϡΎδϘϧϻ΍

ΪϨϋ νήόΗ δϧϻ΍ ΎϳϼΧ

΍ ΎϬϨϣ ΔϔϠΘΨϣ Ϟϣ΍Ϯόϟ ϢδΠϟ΍ ΝέΎΧ ϥΎ ϕϮϓ ΔόηϷ΍ ˬΔϴϨϴδϟ΍ ΔόηϷ

ΔϴϟΎόϟ΍ Γέ΍ήΤϟ΍ϭ ΔϴϧΎσήδϟ΍ ν΍ήϣϷ΍ Νϼϋ ϰϓ ϡΪΨΘδϤϟ΍ ϦϴδϴϣϮΘϴϤϟ΍ έΎϘϋ ˬΔϴΠδϔϨΒϟ΍

ΕΎϴϨϘΗ ϡ΍ΪΨΘγ΍ ϢΗ Ϊϗϭ .

ϭ ΔϤϴϠγ Ωήϓ΍ Ϧϣ ΎϳϼΧ ϰϠϋ ΔϴΌϳΰΠϟ΍ ΔϳϮϠΨϟ΍ ΔΛ΍έϮϟ΍

΃ ϣ Ωήϓ΍ Ϧϣ ϯήΧ Α ϦϴΑΎμ

ξόΒ ΔϴΛ΍έϮϟ΍ ν΍ήϣϷ΍

.

ϡϮγϮϣϭήϜϟ΍ ϥ΃ ϰϠϋ ΓΪϛΆϣ Ξ΋ΎΘϨϟ΍ Ε˯ΎΟ ϥΎδϧϻ΍ ΎϳϼΨΑ 9

Ϧϣ ΓήϴΒϛ ΔϘτϨϣ ϰϠϋ ϯϮΘΤϳ ϯάϟ΍ϭ

ήϴϣϭήΘϨδϟ΍ Ώήϗ ϦϴΗΎϣϭήϛϭήϴΘϴϬϟ΍

βϜόΑ ϦϴδϴϣϮΘϴϤϟ΍ ΓΩΎϤϟ ΎϳϼΨϟ΍ νήόΗ ΪόΑ ΕΎϫϮθΘϠϟ Ύ΋΍ϮΘΣ΍ ήΜϛϷ΍ Ϯϫ

ϡϮγϮϣϭήϜϟ΍

ϪΒθϳ ϯάϟ΍ 8 ϡϮγϮϣϭήϜϟ΍ ΎϤΠΣ

ΔϴϨϴΗΎϣϭήϛϮϳ ΔϘτϨϣ ϰϠϋ ϯϮΘΤϳ ϪϨϜϟϭ 9 ήϴϣϭήΘϨδϟ΍ Ώήϗ

.

ΔϴϣϮγϮϣϭήϜϟ΍ Ε΍Ϋϭάθϟ΍ ΔΒδϧ ϥ΃ ήϛάϟΎΑ ήϳΪΠϟ΍ϭ ΕϻΩΎΒΗ ΔΌϴϫ ϰϠϋ

ϦϴϣϮγϮϣϭήϜϟ΍ ϦϴΑ 9

ΕΎϣϮγϮϣϭήϜϟ΍)

ΔϬΑΎθΘϤϟ΍

ϦϴΗΎϣϭήϛϭήϴΘϴϬϟ΍ ΔϘτϨϣ ϰϓ ϚϟΫϭ( ϮΘΤϤϟ΍ Ε΍Ϋϭάθϟ΍ Ϧϣ ϕϼσϻ΍ ϰϠϋ ήΜϛϷ΍ ΖϧΎϛ

ϰϠϋ Δϳ ϯΪΣ΍

ϡϮγϮϣϭήϜϟ΍

ϯήΧ΍ ΕΎϣϮγϮϣϭήϛϭ9 .

θϟ΍ ϩάϫ ΙϭΪΣ Δϴϔϴϛ ϢϬϓ ϰϓ ϖϤόΘϠϟϭ ϦϜϤϳ ϰΘϟ΍ ΔϴϣϮγϮϣϭήϜϟ΍ Ε΍Ϋϭά

ΎϬΘγ΍έΩ Ϧϣ Δϴ΋΍ϮΘγϻ΍ ΔϠΣήϤϟ΍ ϰϓ

ϯίϮΘϴϤϟ΍ ϡΎδϘϧϻ΍

ΎϳϼΨϟ΍ ΔϳϮϧ΃ κΤϓ ϢΗ ΔϴϨϴΒϟ΍ ΔϠΣήϤϟ΍ ϰϓ

ϥ Ω ϝ΍ Φδϧ ΔϠΣήϣ ϞΒϗ έΎϘόϠϟ ΎϬοήόΗ ΪόΑ ΃

.

Δγ΍έΪϟ΍ Ϧϣ ˯ΰΠϟ΍ ΍άϫ ΖΒΛ΃

ϦϴϣϮγϮϣϭήϜϟ΍ Ϧϣ ϦϴΗΎϣϭήϛϭήϴΘϬϟ΍ ΔϘτϨϣ ϥ΃

ϡίϼΘΗ9 ϰϠϋ ϥϮϜΗ ΎϧΎϴΣ΍ϭ ΎϳϮγ

ΎϳϼΨϟ΍ Ϧϣ ΔΒδϧ ϰϓ ΓΪΣ΍ϭ ΔϴϨϴΗΎϣϭήϛ ΔϠΘϛ ΔΌϴϫ Ύϴ΋ΎμΣ΍ ϯΰϐϣ Ε΍Ϋ)

ϦϴδϴϣϮΘϴϤϟ΍ έΎϘόϟ ΖοήόΗ ϰΘϟ΍( ΎϣΎϤΗ

ϰϠϋ ϯϮΘΤΗ ϰΘϟ΍ ΔΒδϨϟΎϛ ΕϻΩΎΒΗ

ΔϴϣϮγϮϣϭήϛ ΪΟϮϳ Ϣϟ ΎϤϨϴΑ

ϰΘϟ΍ϭ ΔτΑΎπϟ΍ ΔϋϮϤΠϤϟ΍ ΎϳϼΧ ϰϓ ϡίϼΘϟ΍ ΍άϫ

έΎϘόϠϟ νήόΘΗ Ϣϟ Λ΍έϭ ν΍ήϣ΄Α ϦϴΑΎμϤϟ΍ Ω΍ήϓϷ΍ ΎϳϼΨϓ ϚϟΫ ϰϟ΍ ΔϓΎο΍ϭ .

ϴ ΔϨϴόϣ Δ ϰϠϋ ΓέΩΎϗ ήϴϏ ΎϬϠόΠΗ

ΔϴΛ΍έϮϟ΍ ΓΩΎϤϟΎΑ έήπϟ΍ Ρϼλ΍

ΎϬϧΈϓ ˬ ΔϟΎόϓ ήϴϏ ΓέϮμΑ ΎϫΩϮΟϭ ϭ΃ ΕΎϨϴΠϟ΍ ξόΑ ΩϮΟϭ ϡΪόϟ ΔΠϴΘϧ ϼϛ ΪϘΘϔΗ

τϨϤϟ΍ ϡίϼΗ Ϧϣ ΔϴϨϴΗΎϣϭήϛϭήϴΘϴϬϟ΍ ΔϘ

ϦϴϣϮγϮϣϭήϜϟ΍ ϰϓ ΕϻΩΎΒΘϟ΍ϭ ˬ 9

ϥ΃ ϰϠϋ ϝΪϳ ΎϤϣ ΪϤΘόϳ ϡίϼΘϟ΍ ΍άϫ

143

Arabic summary

ϥ΃ϭ ΕΎϨϴΠϟ΍ ξόΑ ϰϠϋ Θϟ΍ ΔϴϣϮγϮϣϭήϜϟ΍ Ε΍Ϋϭάθϟ΍

ΪϨϋ ΓήηΎΒϣ ΎϬϨϳϮϜΗ ΃ΪΒϳ Δϴ΋΍ϮΘγϻ΍ ΔϠΣήϤϟ΍ ϰϓ ήϬψΗ ϰ

Ϡϟ ΎϬοήόΗ ϥ Ω ϝ΍ Ρϼλ΍ ΔϴϠϤϋ ϝϼΧ Ϧϣ έΎϘό ΃

.

ΔϴϟΎόϟ΍ Γέ΍ήΤϟ΍ ΔΟέΩϭ ΔϴΠδϔϨΒϟ΍ ϕϮϓ ΔόηϷ΍ϭ ΔϴϨϴδϟ΍ ΔόηϷ΍ ϥ΃ ΎϧΪΟϭ ϯήΧϷ΍ Ϟϣ΍Ϯόϟ΍ ήϴΛ΄Η Δγ΍έΩ ΪϨϋ ΎϬϟ

ϦϴΗΎϣϭήϜϟ΍ ϰϠϋ ΎϬΑΎθϣ ΍ήϴΛ΄Η ˬ

ΔϴΛ΍έϮϟ΍ ΓΩΎϤϟΎΑ ΔϔϠΘΨϣ ΍έ΍ήο΍ ΙΪΤΗ Ϟϣ΍Ϯόϟ΍ ϚϠΗ ϥ΃ ϢϏήΑ ϳ ΍άϫϭ .

ϥ΃ ΢οϮ

ϖσΎϨϣ ϡίϼΗ ϪτϴθϨΗ ϢΘϳ ϯάϟ΍ ϯϮϠΨϟ΍ ΞϣΎϧήΒϟ΍ Δϳ΍ΪΑ Ϯϫ ϥϮϜϳ Ϊϗ ΔϬΑΎθΘϤϟ΍ ΕΎϣϮγϮϣϭήϜϠϟ ϦϴΗΎϣϭήϛϭήϴΘϴϬϟ΍

ΔϴΛ΍έϮϟ΍ ΓΩΎϤϟΎΑ έήο ϯ΃ ΙϭΪΣ ΪϨϋ ΔϴϨϴΗΎϣϭήϜϟ΍ ˯΍ΰΟϷ΍ ϡίϼΗ ΔϴϛήΣ ϰϓ ϑϼΘΧϻ΍ ϥΈϓ ϯήΧ΃ ΔϴΣΎϧ Ϧϣ.

ϡίϼΘϟ΍ ϰϓ Ύϫέ΍ήϤΘγ΍ ϯ΃) Ύμϔϧ΍ ϭ΃ ΔϴϠΨϟ΍ ΓέϭΪϟ ΔϔϠΘΨϤϟ΍ ϞΣ΍ήϤϟ΍ ˯ΎϨΛ΃

ΔϴϧΎΛ ΎϬϟ ϚϠΗ ξόΒϟ νήόΘϟ΍ ΪόΑ (

ΚΤΒϟ΍ Ϧϣ ΪϳΰϤϟ΍ ΝΎΘΤϳ Ϟϣ΍Ϯόϟ΍

ΔϴϨϴΗΎϣϭήϜϟ΍ ΓΩΎϤϟ΍ ΔϴϜϴϣΎϨϳΩ Δγ΍έΩ Ϧϣ ϦϜϤΘϠϟ ΓΪϳΪΠϟ΍ ΕΎϴϨϘΘϟ΍ϭ ΎϳϼΨϟ΍ ϰϓ

ΔϴΤϟ΍

ΔϴϣϮγϮϣϭήϜϟ΍ Ε΍Ϋϭάθϟ΍ ΙϭΪΣ ΎϬϘϳήσ Ϧϋ ϢΘϳ ϰΘϟ΍ ΕΎϴϟϵ΍ ΪϳΪΤΗ ϰϟΎΘϟΎΑϭ ϢϬϓ ϰϟ΍ ϯΩΆϳ Ϊϴϛ΄ΘϟΎΑ ΍άϫϭ .

ϔϴϛϭ ϡϮϨϴΠϠϟ ϖϤϋ΃

΍ ΔΠϴΘϧ ΙΪΤΗ ϰΘϟ΍ϭ ΔϴϧΎσήδϟ΍ ν΍ήϣϷ΍ Νϼϋ ϭ ΙϭΪΣ Δϴ ΔϴϨϴΠϟ΍ Ε΍ήϴϴϐΘϟ

ΔϴϣϮγϮϣϭήϜϟ΍ϭ .

.

144