Changes in chromatin organization of human cells in response to genotoxic stress
Abdel-Halim Mahfouz, H.I.
Citation
Abdel-Halim Mahfouz, H. I. (2009, February 24). Changes in chromatin
organization of human cells in response to genotoxic stress. Retrieved from
Abbreviations
(6-4)PPs (6-4)-photoproducts ATR ATM- and Rad3-related
CPD Cyclobutane pyrimidine dimmers CT Chromosome territories
DDR DNA damage response
DNA-PK DNA-dependent protein kinase DSB Double strand break
GFP Green fluorescent protein HP1 Heterochromatin protein 1 HSF Heat shock transcription factor HSP Heat shock/stress proteins ICLs Interstrand cross-links
IR Ionizing radiation LET Linear energy transfer
MMC Mitomycin C
MMS Methylmethane sulfonate MNU Methylnitrosourea
NER Nucleotide excision repair NHEJ Non-homologous end joining ROS Reactive oxygen species RNAi RNA interfering
SSB Single strand break ssDNA Single strand DNA
UV Ultraviolet
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List of Publications
Abdel-Halim, H.I., Boei, J.J.W.A., Godthelp, B. and Mullenders, L.H.F. (2009). Impact of DNA repair on DNA damage induced heterochromatin pairing in human cells. In preparation.
Abdel-Halim, H.I., Mullenders, L.H.F., Boei, J.J.W.A. (2006). Pairing of heterochromatin in response to cellular stress. Experimental cell Res. 312, 1961-1969.
Abdel-Halim, H.I., Natarajan, A.T., Mullenders, L.H.F., Boei, J.J.W.A. (2005). Mitomycin C- induced pairing of heterochromatin reflects initiation of DNA repair and chromatid exchange formation, J. Cell Sci. 118, 1757-1767.
Abdel-Halim, H. I., Imam S. A., Badr, F. M., Natarajan, A. T., Mullenders, L.H.F. and Boei, J.J.W.A. (2004). Ionizing radiation induced instant pairing of heterochromatin of homologous chromosomes in human cells. Cytogenet. Genome Res. 104, 193-199.
Imam, S.A., Badr, F.M., Shalaby, I.S. and Abdel-Halim, H.I. (2002). Chromosomal damage in the somatic and germ cells of schistosomiated mice treated with nicotine and praziquantel. J.Egypt.Ger.Soc.Zool. 39C, Histol. & Histochem. 355-371.
Badr, F.M., Imam, S.A., Abdel-Halim, H.I. and Shalaby. I.S. (2002). Cytogenetic studies on praziquantel in experimental Schistosomiasis. J. Egypt. Ger.Soc.Zool. 39C, Histol. &
Histochem. 479-497.
Badr, F.M., Imam, S.A., Abdel-Halim, H.I. and Shalaby. I.S. (2002). Mutagenicity of nicotine in Schistosoma mansoni-infected mice. Egypt. J. Biol. 4, 95-108.
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Curriculum Vitae
The author of this PhD thesis was born in Ismailia, Egypt in 1969. She graduated from the General Secondary school of Abu Suwair in the same city in May 1986 and after that, she started her university education at Suez Canal University, Ismailia, Egypt. In May 1990, she graduated from the Faculty of Science and received her Bachelor degree of Science in Zoology with Excellent-Honor Grade (85 %). In the same year, 1990, she was offered a position of Demonstrator at the Department of Zoology in the same University to participate in the teaching responsibilities and to do her postgraduate studies. In May 1992, she completed within one academic year the courses required for the Master degree. She got her Master degree of Science in Zoology in 1997 “with distinction” after a scientific study on mice aiming at the evaluation of mutagenic risk of exposure to nicotine and the anti-schistosomal drug (praziquantel) as well as the synergistic effect of these chemicals. In 1998, she continued the work as assistant lecturer while preparing to study the PhD. In 1999, she was granted two years scholarship from the Egyptian government to do the experimental work of the PhD in The Netherlands. She arrived at Leiden University Medical Center in December 1999 to start her work at the Department of Toxicogenetics under supervision of Prof. Dr. A.T. Natarajan and Prof. Dr. Leon Mullenders. In 2002 she was admitted to complete the PhD in the Netherlands. During her PhD period her scientific research has mainly focused on chromatin organization of human cells exposed to genotoxic stress. Finally, after obtaining her PhD, she will be working as a lecturer postdoc at the Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt.
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