Cover Page
The handle http://hdl.handle.net/1887/137309 holds various files of this Leiden University dissertation.
Author: Wang, Z.
Exploring Grainyhead-like 2 target
genes in breast cancer
Exploring Grainyhead-like 2 target genes in breast cancer
Zi Wang, March 2020.
Zi Wang was supported by China Schorlarship Council (201506200095).
This research was carried out at the Division of Drug Discorvery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. The research was supported by the Dutch Cancer Society (grant no. 10967).
ISBN 978-94-92597-45-8 Printed by Printsupport4U, NL
Cover and lay-out of this thesis designed by Zi Wang.
© Copyright, Zi Wang, 2020.
Exploring Grainyhead-like 2 target
genes in breast cancer
PROEFSCHRIFT ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus, prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsday, 6 oktober 2020
klokke 10:00 uur
door
Zi Wang | 王梓
Promotor
Prof. dr. E.H.J. Danen Copromotor
Dr. J.M. Zweemer Promotiecommissie Prof. dr. H. Irth (Chair)
Leiden University, Leiden
Prof. dr. J.A. Bouwstra (Secretary)
Leiden University, Leiden
Prof. dr. B. van de Water
Leiden University, Leiden
Prof. dr. J. Martens
Erasmus University Medical Center, Rotterdam
Dr. G. van der Pluijm
Table of Contents
Chapter 1
General Introduction and outline of this thesis 1~25
Chapter 2
The role of GRHL2 in luminal- and basal like breast cancer 26~48
Chapter 3
Genome-wide identification of binding sites of GRHL2 in luminal-like and basal A subtypes of breast cancer
49~73 Chapter 4
Dynamic changes in nascent RNA after GRHL2 loss in luminal-like breast cancer 74~108
Chapter 5
Identification of direct GRHL2 target genes in luminal-like breast cancer through integration of ChIP-seq and Bru-seq
109~126 Chapter 6
