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Cover Page The handle http://hdl.handle.net/1887/73833 holds various files of this Leiden University dissertation. Author: Douna, H. Title: B cell modulation in atherosclerosis Issue Date: 2019-06-06

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Cover Page

The handle http://hdl.handle.net/1887/73833 holds various files of this Leiden University

dissertation.

Author: Douna, H.

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B cell modulation

in atherosclerosis

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Cover design: Rinske Douna

Thesis lay-out: Optima, Rotterdam, The Netherlands Printing: Optima, Rotterdam, The Netherlands

© Copyright, Hidde Douna, 2019 ISBN: 978-94-6361-274-6

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B cell modulation in atherosclerosis

Proefschrift

Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op donderdag 6 juni 2019

klokke 15.00 uur

door

Hidde Douna

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Promotor: prof. dr. J. Kuiper

Co-promotor: dr. A.C. Foks and dr. G.H.M. van Puijvelde Promotiecommissie

prof. dr. Irth – LACDR (voorzitter)

prof. dr. J.A. Bouwstra – LACDR (secretaris) prof. dr. E. Lutgens

prof. dr. P.H.A. Quax prof. dr. C.J. Binder

The research described in this thesis was performed at the division of Biotherapeu-tics of the Leiden Academic Centre for Drug Research (LACDR), Leiden University (Leiden, The Netherlands).

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

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Table of contents

1. General introduction 7

2. Novel B cell subsets in atherosclerosis 35 3. Bidirectional effects of IL-10+ regulatory B cells in Ldlr-/- mice 49

4. TIM-1 mucin domain-mutant mice display exacerbated atherosclerosis 71 5. IFNγ-stimulated B cells inhibit T follicular helper cells and protect against

atherosclerosis

91

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