Cover Page
The handle http://hdl.handle.net/1887/81820 holds various files of this Leiden University dissertation.
Author: Koedoot, E.
ISBN
978-94-028-1744-7
Printing: Ipskamp Printing, Amsterdam
Printing of this thesis was kindly supported by Nikon
© 2019 Esmee Koedoot
All rights reserved. No part of this thesis may be reproduced, stored, translated or transmitted in any form or by any means now or hereafter, electronic or mechanical, without written permission from the author.
RNA splicing in breast cancer progression
RNA splicing
in breast cancer progression
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van de Rector Magnificus, prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op dinsdag 17 december 2019 klokke 15 uur
door
Esmee Koedoot
Promotor
Prof. Dr. B. van de Water Drug Discovery and Safety, LACDR, Leiden University, Leiden
Co-promotor
Dr. S.E. Le Dévédec Drug Discovery and Safety, LACDR, Leiden University, Leiden
Promotion committee
Prof. Dr. H. Irth Biomolecular Analysis, LACDR, Leiden University, Leiden, president
Prof. Dr. J.A. Bouwstra BioTherapeutics, LACDR. Leiden University, Leiden, secretary
Prof. Dr. J.W.M. Martens Medical Oncology, Erasmus MC, Rotterdam
Prof. Dr. A. Sonnenberg Cell Biology, Netherlands Cancer Institute, Amsterdam Prof. Dr. P. ten Dijke Cell and Chemical Biology, LUMC, Leiden
Prof. Dr. B.E. Snaar-Jagalska Cell Biology and Genetics, IBL, Leiden University, Leiden
Table of Contents
Chapter 1 1
Introduction, aim and scope of the thesis
Chapter 2 9
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
Chapter 3 37
Splicing factors and hallmarks of breast cancer
Chapter 4 55
Co-regulated gene expression of splicing factors as drivers of cancer progression
Chapter 5 75
Unraveling the spliceosomal control of breast cancer cell motility behavior
Chapter 6 97
Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention
Chapter 7 121
Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy
Chapter 8 139
Discussion and Conclusion
Appendix 149
References 150
Abbreviations 167
Nederlandse Samenvatting 169
List of Publications 173
