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The handle http://hdl.handle.net/1887/42540 holds various files of this Leiden University dissertation
Author: Danso-Eweje, M.O.
Title: Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Issue Date: 2016-09-01
Development of
human skin equivalents to unravel the impaired skin barrier in atopic
dermatitis skin
Mogbekeloluwa Oluwadamiloju Danso-Eweje
3
ISBN: 978-90-9029851-1
© 2016 Mogbekeloluwa oluwadamiloju Danso-Eweje
All rights reserved. No part of this publication may be reproduced or transmitted without permissions in writing from the author. The copyright of the articles that have been accepted for publication or published have been transferred to the respective journals.
Design: New Season Printing: Gildeprint
The printing of this thesis was partially sponsored by Galapagos BV, STW
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnifi cus Prof. mr. C.J.J.M Stolker, volgens besluit van het College voor Promoties
te verdedigen op donderdag, 1 september 2016 | klokke 15:00uur
door
Mogbekeloluwa Oluwadamiloju Danso-Eweje
Geboren op 09 september 1988 | te Warri, Nigeria
Development of
human skin equivalents to unravel the impaired skin barrier in atopic
dermatitis skin
The research described in this thesis was performed at the Division of Drug Delivery Technology of the Leiden Academic Centre for Drug Research (LACDR) and at the Leiden University Medical Centre, Leiden, The Netherlands.
5
Promotor:
Prof. dr. J.A. Bouwstra
Co-promotor:
Dr. A. El Ghalbzouri
Promotiecommissie:
Prof.dr. P.H. van der Graaf, Leiden University, LACDR, Chair Prof.dr. M. Danhof, Leiden University, LACDR, Secretary Prof.dr. M.H. Vermeer, Leiden University, LUMC
Prof.dr. M. Schmuth, Innsbruck Medical University, Austria Prof.dr. W. Jiskoot, Leiden University, LACDR
Dr. S. Kezic, AMC, Amsterdam
Contents
C H A P T E R 1
Introduction
C H A P T E R 2
Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition
C H A P T E R 3
TNF-α and TH2 cytokines induce atopic dermatitis-like features on epidermal diff erentiation proteins and stratum corneum lipids in human skin equivalents
C H A P T E R 4
Exploring the potentials of nurture: 2nd and 3rd generation explant human skin equivalents
C H A P T E R 5
Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro
C H A P T E R 6
An ex vivo human skin model for studying skin barrier repair
C H A P T E R 7
Summary and Perspectives
C H A P T E R 8
Nederlandse samenvatting List of publications Curriculum Vitae
This research was supported by the Dutch Technology Foundation (Project number 10703)
