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The handle http://hdl.handle.net/1887/46476 holds various files of this Leiden University dissertation
Author: Tieken, Chris
Title: Tissue factor isoforms and factor VII in cancer progression
Issue Date: 2017-03-09
Tissue Factor isoforms and Factor VII in cancer progression
Tissue Factor isoforms and Factor VII in cancer progression Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 9 maart 2017
klokke 15:00 uur
door
Christiaan Tieken geboren te Leiden
in 1985
Promotores: Prof. dr. H.H. Versteeg
Prof. dr. P.H. Reitsma
Promotiecommissie: Prof. dr. A.J. van Zonneveld Prof. dr. M.J.T.H. Goumans
Prof. dr. P.H.A. Quax
Prof. dr. H. ten Cate (Universiteit van Maastricht) Dr. C.A. Spek (Universiteit van Amsterdam)
The research described in this thesis was funded by NWO grant 91710329.
The research was performed at the Einthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Cover: Chris Tieken
©2017 by Chris Tieken
Printed by: Gildeprint – the Netherlands
Voor mijn ouders en broer Voor Ana
Contents
Chapter 1 – General introduction and outline of this thesis 9
Chapter 2 – Anticoagulants versus cancer (review) 15
Chapter 3 -‐‑ Alternatively spliced tissue factor promotes
breast cancer growth in a β1 integrin-‐‑dependent manner 33
Chapter 4 -‐‑ Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting
breast cancer progression 61
Chapter 5 -‐‑ Ectopic Factor VII associates with survival
and regulates tumor progression in breast cancer 89
Chapter 6 -‐‑ Tissue Factor associates with survival and
regulates tumor progression in osteosarcoma 111
Chapter 7 -‐‑ Tissue Factor isoform and Factor VII
expression and clinical outcome in colorectal cancer 135
Chapter 8 – General discussion and summary 151
Nederlandse discussie en samenvatting 165
Publications 174
Dankwoord 175
Curriculum Vitae 177
