Metabolic alterations in dialysis patients Drechsler, C.

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(1)Metabolic alterations in dialysis patients Drechsler, C.. Citation Drechsler, C. (2010, June 8). Metabolic alterations in dialysis patients. Retrieved from https://hdl.handle.net/1887/15658 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/15658. Note: To cite this publication please use the final published version (if applicable)..

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(448) . .

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(455) (

(456) 1LNEJCAN 4ANH=C &AE@AH>ANC %ANI=JU

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(459) 8.9-;%/?

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(465) >;6388?/<=

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(468) 98/!38/;%/<1QLLH, ,

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(471) 3.8/B8=

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(474) 7 &9- "/:2;96

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(477) 3.8/B8=

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(479) +KNP=HEPU NEOG BKN @E=HUOEO L=PEAJPO SEPD @EBBANAJPHARAHOKBOANQI?=H?EQI LDKOLDKNQO =J@.2&PDA"E=HUOEO-QP?KIAO =J@.N=?PE?A.=PPANJO1PQ@U"-..1

(480) 73.8/B3<

(481). . 7KQJC#5 H>ANP(+ 1=P=U=PDQI1 AP=H

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(483) 3.8/B 8=

(484). .

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(487) 73.8/B3<

(488). . RN=I ++ 1NAA@D=N= 0 RN=I ") +Q?DJE?G 0 $AEJ .

(489) #JNKHHIAJP L=N=PDUNKE@ DKNIKJA HARAH EO = JAS I=NGAN KB OQNRER=H EJ DAIK@E=HUOEO =J@ LANEPKJA=H@E=HUOEOPDAN=LUBKNQNAIE=

(490) 73.8/B3<

(491). . RN=I ++ +EPPI=J , +UEJP ++ $AEJ .

(492) 'ILKNP=J?A KB HKS OANQI EJP=?P L=N=PDUNKE@DKNIKJA=O=LNA@E?PKNKBIKNP=HEPUEJDAIK@E=HUOEO=J@LANEPKJA=H @E=HUOEO L=PEAJPO UA=NO KB LNKOLA?PERA K>OANR=PEKJ

(493) 7 3.8/B 3<

(494). . %QD(7 !DAJ&! !DQ=JC&7 &Q=JC1! !DEAJ*! *=E7&

(495) 0EOGB=?PKNO=J@NEOG BKNIKNP=HEPUKBIEH@DULKL=N=PDUNKE@EOIEJDAIK@E=HUOEOL=PEAJPO

(496) 73.8/B 3<

(497). . $KQMQA " )=H=JP=N 8=@AD ) )KLLHA ( AP =H

(498) LNKLKOA@ JKIAJ?H=PQNA =J@ @E=CJKOPE??NEPANE=BKNLNKPAEJ AJANCUS=OPEJCEJ=?QPA=J@?DNKJE?GE@JAU@EOA=OA

(499) 3.8/B8=

(500). . )=H=JP=N 8=@AD ) 'GEVHAN 2 HK?G % RN=I ++ )KLLHA ("

(501) +=HJQPNEPEKJ EJn=II=PEKJ?KILHATOUJ@NKIAEJ@E=HUOEOL=PEAJPO?=QOAO=J@?KJOAMQAJ?AO

(502) 73.8/B3<

(503). . @A +QPOANP 0 %NKKPAJ@KNOP "! . KAO?DKPAJ #5 AP =H

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(505) 7638">=;

(506) . !KAJ% =HH=JPE. KJQ??E# AP=H

(507) KJAI=NGANOEJPDA@E=CJKOEOKBHKSPQNJKRAN KOPAK@UOPNKLDUEJD=AIK@E=HUOEOL=PEAJPO

(508) "/:2;963+6';+8<:6+8=

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(510) 2DAOLA?PNQIKB>KJA@EOA=OAEJAJ@ OP=CANAJ=H B=EHQNA =JARKHREJC@EOKN@AN

(511) 3.8/B8=

(512). . *KJ@KJ %+ +=NPU ! +=N?D=EO 1( %QANEJ . +APEREAN $ @A 4ANJAFKQH +!

(513) NPANE=H ?=H?Em?=PEKJO =J@ >KJA DEOPKIKNLDKIAPNU EJ AJ@ OP=CA NAJ=H @EOA=OA

(514) 7&9-"/:2;96

(515). .

(516) 2+:=/;. . *KJ@KJ%+ +=N?D=EO1( %QANEJ. KQPKQUNEA. +APEREAN$ @A4ANJAFKQH+!

(517) OOK?E=PEKJ KB >KJA =?PEREPU ?=H?EQI HK=@ =KNPE? OPEBBJAOO =J@ ?=H?Em?=PEKJO EJ #10"

(518) 7&9-"/:2;96

(519). . 5=JJAN! )N=JA4 +=NV5 AP=H

(520) 0=J@KIEVA@?KJPNKHHA@PNE=HKJPDAABm?=?U=J@ O=BAPUKB=PKNR=OP=PEJEJL=PEAJPOSEPDPULA@E=>APAOKJDAIK@E=HUOEO"OPQ@U @AIKCN=LDE?=J@>=OAHEJA?D=N=?PANEOPE?O

(521) 3.8/B699.$;/<<%/<

(522). . 5=JJAN! )N=JA4 +=NV5 AP=H

(523) PKNR=OP=PEJEJL=PEAJPOSEPDPULA@E=>APAO IAHHEPQOQJ@ANCKEJCDAIK@E=HUOEO

(524) "816!/.

(525). . 1=I>NKKG., !DAJ(1 +=N?D*+ AP=H

(526) 1ANQIL=N=PDUNKE@DKNIKJAEO=OOK?E=PA@ SEPDEJ?NA=OA@IKNP=HEPUEJ@ALAJ@AJPKB DU@NKTUREP=IEJ@OP=PQO >KJAI=OO =J@NAJ=HBQJ?PEKJEJPDABN=EH=J@RANUKH@=?KDKNPOPQ@U

(527) 6388.9-;3896!/=+,

(528). . !DEQ)! !DQ=JC*+ *AA,. AP=H

(529) 'JOQHEJOAJOEPEREPUEOEJRANOAHU?KNNAH=PA@SEPD LH=OI=EJP=?PL=N=PDUNKE@DKNIKJAHARAH

(530) !/=+,963<7

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(532) %HQ?KOA EJPKHAN=J?AEO=OOK?E=PA@SEPD=HPANA@?=H?EQIDKIAKOP=OEO=LKOOE>HAHEJG>APSAAJ EJ?NA=OA@ OANQI ?=H?EQI ?KJ?AJPN=PEKJ =J@ ?=N@EKR=O?QH=N @EOA=OA IKNP=HEPU

(533) !/=+,963<7

(534). . %=@=HH=D +$ AH 1D=D=SU + J@NASO % AP =H

(535) $=?PKNO IK@QH=PEJC ?UPKOKHE? ?=H?EQI

(536) 0KHAEJHELE@IAP=>KHEOI=J@?=N@EKR=O?QH=NIKN>E@EPU=J@IKNP=HEPUEJ LANEPKJA=H@E=HUOEOL=PEAJPO

(537) .?$/;3=3+6

(538). . 0=K "1 1DED +1 +KDEJE 0

(539) #BBA?P KB OANQI L=N=PDUNKE@ DKNIKJA =J@ >KJA I=NNKSm>NKOEOKJPDANAOLKJOAPKANUPDNKLKEAPEJEJQNAIE=

(540) "816!/.

(541). . +AUPAO" KCEJ# += "QGAO.. +=OONU1%

(542) #BBA?PKBL=N=PDUNKE@DKNIKJAKJ ANUPDNKLKEAOEO

(543) 6388?/<=

(544). . +=OONU1% HATEASE?V(+ %=?EKJC8 )HEJCAN+

(545) 1A?KJ@=NUDULANL=N=PDUNKE@EOI =J@PDAEIIQJAOUOPAIEJ?DNKJE?NAJ=HB=EHQNA

(546) &/738"/:2;96

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(548) 2DA?D=JCAOEJ?KJPN=?PEHAOP=PQOKBOEJCHA R=O?QH=NOIKKPDIQO?HA?AHHO=J@RAJPNE?QH=N?AHHOEJ@Q?A@>U>.2&

(549) 30/ &-3

(550). .

(551) $'+8.79;=+63=B38.3+6B<3<:+=3/8=<. . . =?VUJOGE 0 +=OONU 1% )KD=J 0 +=CKPP + 1=CHEGAO7 N=QP>=N ,

(552) #BBA?P KB L=N=PDUNKE@ DKNIKJA KJ IUK?=N@E=H AJANCU IAP=>KHEOI EJ PDA N=P

(553) 3.8/B 8=

(554). . I=JJ) 2KNJEC( $HA?DPAJI=?DAN! ,=>KGKR +=HH% 0EPV#

(555) HKK@ LNAOOQNA EJ@ALAJ@AJP S=HH PDE?GAJEJC KB EJPN=IUK?=N@E=H =NPANEKHAO EJ ATLANEIAJP=H QN=AIE=ARE@AJ?ABKN=LANIEOOERA=?PEKJKB.2&

(556) "/:2;963+6';+8<:6+8=

(557). . I=JJ) 0EPV#

(558) !=N@E=?@EOA=OAEJ?DNKJE?QNAIE=L=PDKLDUOEKHKCU

(559) .?%/8 %/:6+-/'2/;

(560). . )KO?D+ &=QO>ANC+ 4KNI>NK?G) AP=H

(561) 'IL=ENA@nKS IA@E=PA@R=OK@EH=PEKJ KB PDA >N=?DE=H =NPANU EJ L=PEAJPO SEPD LNEI=NU DULANL=N=PDUNKE@EOI EILNKRAO =BPANL=N=PDUNKE@A?PKIU

(562) +;.39?+<-%/<

(563). . -D=N= , &EN=I=POQ ) 1DECAI=POQ 1 AP =H

(564) #BBA?P KB L=N=PDUNKE@ DKNIKJA KJ HABPRAJPNE?QH=N@E=OPKHE?BQJ?PEKJEJL=PEAJPOSEPDLNEI=NUDULANL=N=PDUNKE@EOI

(565) !38/;6/-=;96B=/!/=+,

(566). . 0KOP=J@ 1% "NQAGA 2

(567) .=N=PDUNKE@ DKNIKJA REP=IEJ " =J@ ?=N@EKR=O?QH=N @EOA=OAEJ?DNKJE?NAJ=HB=EHQNA

(568) 3.8/B8=

(569). . 4AOPANC==N@ & -1PANC==N@ )*

(570) ,KNIK?=H?AIE= =J@ LANOEOPAJP AHAR=PA@ OANQI ?KJ?AJPN=PEKJO KB L=N=PDUNKE@ DKNIKJA =BPAN KLAN=PEKJ BKN OLKN=@E? L=N=PDUNKE@ =@AJKI= ARE@AJ?A KB EJ?NA=OA@ IKN>E@EPU BNKI ?=N@EKR=O?QH=N @EOA=OA

(571) *9;6.&>;1

(572). . )=IU?DAR=# 1QJ@OBFKN@( (KN@A0

(573) 1ANQIL=N=PDUNKE@DKNIKJAHARAHOLNA@E?P ?KNKJ=NU DA=NP @EOA=OA PDA 2NKIOK 1PQ@U

(574) >; +;.39?+<- $;/? %/2+,36

(575). . !=JK,( 0KPD& L=NE?EK+ AP=H

(576) +=HJQPNEPEKJEJDAIK@E=HUOEO@E=>APE?L=PEAJPO AR=HQ=PEKJ=J@LNKCJKOPE?EJnQAJ?A

(577) 3.8/B8=

(578). . .QLEI* &AEI>QNCAN- /QNAODE0 'GEVHAN2 1PAJREJGAH.

(579) ??AHAN=PA@HA=J >K@UI=OOHKOOEJEJ?E@AJP?DNKJE?@E=HUOEOL=PEAJPOSEPD@E=>APAOIAHHEPQO

(580) 3.8/B 8=

(581). . "SUAN(2 *=NERA *AQJC( AP=H

(582) NAJQPNEPEKJ=HOP=PQOEJ@E?=PKNO=OOK?E=PA@SEPD IKNP=HEPUEJPDA&AIK@E=HUOEO&#+-1PQ@U3.8/B8=

(583).

(584).

(585) 2+:=/;. . J@NAOO"*

(586) @UJ=IE?>KJAEJL=PEAJPOSEPD?DNKJE?GE@JAU@EOA=OA

(587) 3.8/B8=. . 1=J?DAV %KJV=HAV+! *KLAV =NA=$ =FK+ 1AHC=O0

(588) 1ANQI=H>QIEJHARAHO .

(589). =J =@@EPEKJ=H B=?PKN EILHE?=PA@ EJ DULANL=N=PDUNKE@EOI KQP?KIA EJ LANEPKJA=H @E=HUOEO = LNKOLA?PERA OPQ@U SEPD L=ENA@ >KJA >EKLOEAO

(590) .? $/;3= 3+6

(591) . !=NHOPA@P # 0E@ABAHP . *EJ@ * 0=OP=@ (

(592) 'JPANHAQGEJ EJ@Q?A@ OQLLNAOOEKJ KB >KREJAL=N=PDUNKE@DKNIKJAOA?NAPEKJ

(593) 39<-3%/:

(594). . ,EAHOAJ .) 0=OIQOOAJ ) QPPANO 0 AP =H

(595) 'JDE>EPEKJ KB .2& OA?NAPEKJ >U EJPANHAQGEJ >AP=EJ>KREJAL=N=PDUNKE@CH=J@OEJREPNKEO=OOK?E=PA@SEPD=JQL NACQH=PEKJKBPDA?=H?EQI OAJOEJCNA?ALPKNI0,

(596) 39-2/739:2B<%/<977>8

(597). . #HABPANEKQ$ 2=GA@=1 #>ED=N=) AP=H

(598) 1ANQIHALPEJHARAHEO=NACQH=PKNKB>KJA I=OO

(599) $;9-"+=6-+.&-3(&

(600). . -HIKO (+ 4=VMQAV * I=@K ( &ANJ=J@AV (* %KJV=HAV +(

(601) +EJAN=H IAP=>KHEOI EJ K>AOA L=PEAJPO BKHHKSEJC RANPE?=H >=J@A@ C=OPNKLH=OPU

(602) #,/< &>;1

(603). .

(604)

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