University of Groningen
Immunomodulatory properties of protein hydrolysates
Kiewiet, Mensiena Berentje Geertje
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Publication date: 2018
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Kiewiet, M. B. G. (2018). Immunomodulatory properties of protein hydrolysates. Rijksuniversiteit Groningen.
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Immunomodulatory properties
of protein hydrolysates
The research described in this thesis was financially supported by the University Medical Centre Groningen and FrieslandCampina.
Financial support by the University of Groningen, University Medical Centre Groningen, and the Graduate School of Medical Sciences (GUIDE) for the printing of this thesis is gratefully acknowledged.
Layout Bianca Pijl, www.pijlldesign.nl,
Groningen, The Netherlands
Cover design/illustration Bianca Pijl Printed by Ipskamp Printing
Enschede, The Netherlands
ISBN 978-94-034-0336-6 (print)
978-94-034-0337-3 (digital)
© Copyright 2018 Mensiena Berentje Geertje Kiewiet, Groningen, The Netherlands All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
Immunomodulatory properties
of protein hydrolysates
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus, prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 17 januari 2018 om 16.15 uur
door
Mensiena Berentje Geertje Kiewiet
geboren op 22 oktober 1989 te Winschoten
Promotor Prof. dr. P. de Vos Copromotor Dr. M.M. Faas Beoordelingscommissie Prof. dr. H.J. Wichers Prof. dr. A.J.W. Scheurink Prof. dr. G.J. Navis
Paranimfen
Ineke van Zandbergen Manon Smand
Table of contents Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 9 24 31 57 77 93 109 131 163 193 205 207 211 217 222 223 Immunomodulating properties of protein hydrolysates
for application in cow’s milk allergy Rational and outline of the thesis
Toll-like receptor mediated activation is possibly involved in immunoregulating properties of cow’s milk hydrolysates
Soy and wheat hydrolysates possess Toll-like receptor activating and inhibiting properties contributing to their immunomodulatory effects
The impact of soy hydrolysate on epithelial barrier integrity
Soy and whey hydrolysate induced cytokine expression in dendritic cells and intestinal epithelial cells
Identification of an immunomodulating protein fraction in soy and whey hydrolysates and its resistance to digestion in an infant gastrointestinal model system
Partially hydrolyzed whey proteins prevent clinical symptoms in a cow’s milk allergy mouse model and enhance regulatory T and B cell frequencies
Identification of a TLR2 inhibiting wheat hydrolysate for clinical nutrition
General discussion Appendices Summary Nederlandse samenvatting Dankwoord Curriculum vitae Publication List
