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Doublecortin-like kinase and neuronal differentiation

Dijkmans, T.F.

Citation

Dijkmans, T. F. (2009, October 14). Doublecortin-like kinase and neuronal differentiation. Retrieved from https://hdl.handle.net/1887/14055

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/14055

Note: To cite this publication please use the final published version (if applicable).

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D OUBLECORTIN L IKE K INASE 

AND 

N EURONAL D IFFERENTIATION 

































ThomasF.Dijkmans

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ThomasDijkmans



DoublecortinLikeKinaseandNeuronalDifferentiation



Thesis,LeidenUniversity



October14,2009



ISBN:9789090241180



Cover:ThomasDijkmans

Printing:PrintPartnersIpskamp,Enschede,TheNetherlands



©2009ThomasDijkmans



Nopartsofthisthesismaybereproducedortransmittedinanyformorbyany

meanswithoutwrittenpermissionoftheauthor.

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D OUBLECORTIN L IKE K INASE 

AND 

N EURONAL D IFFERENTIATION 































 Proefschrift



terverkrijgingvan

degraadvanDoctoraandeUniversiteitLeiden,

opgezagvanRectorMagnificusprof.mr.P.F.vanderHeijden,

volgensbesluitvanhetCollegevoorPromoties

teverdedigenopwoensdag14oktober2009

klokke13.45uur

 door



ThomasFrederikDijkmans

geborenteLeiden

in1979





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PROMOTIECOMMISSIE





Promotor Prof.Dr.E.R.deKloet

Copromotor Dr.E.Vreugdenhil



Overigeleden ProfDr.T.J.C.vanBerkel

Prof.Dr.M.Danhof

Dr.N.A.Datson

Prof.Dr.J.N.Noordermeer

Dr.W.J.J.M.Scheenen(RadboudUniversiteitNijmegen)

Prof.Dr.H.P.Spaink

Prof.Dr.J.Verhaagen

(NetherlandsInstituteforNeuroscience,Amsterdam)

Prof.Dr.B.vandeWater









































ThestudiesdescribedinthisthesishavebeenperformedattheDivisionofMedical

Pharmacology, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden

University Medical Center (LUMC), Leiden, The Netherlands. This research is

supported by the Dutch Technology Foundation STW, applied science division of

NWO, and the Technology Program of the Ministry of Economic Affairs (project

numberLFA6332).



Printingofthisdissertationwassponsoredby:

Leiden/AmsterdamCenterforDrugsResearch(LACDR)

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Chapter1



Chapter2





Chapter3







Chapter4





Chapter5





Chapter6



Chapter7





Chapter8







Appendix

GeneralIntroduction



IdentificationofnewNerveGrowthFactorresponsive

immediateearlygenes



Temporalandfunctionaldynamicsofthe

transcriptomeduringNerveGrowthFactorinduced

differentiation



NGFinducedneuritogenesisisregulatedby

phosphorylationofDCLKshortinNs1PC12cells



TranscriptionalregulationofDCLKshortinNs1PC12

cells



GeneralDiscussion



Summary

Samenvatting



ListofAbbreviations

CurriculumVitae

Publications



ColorFigure8,9and10fromChapter4

1

 27



 55





 91



 117



 135

 153



 161





 167



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