University of Groningen
Development of MAPC derived induced endodermal progenitors Sambathkumar, Rangarajan
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Sambathkumar, R. (2017). Development of MAPC derived induced endodermal progenitors: Generation of pancreatic beta cells and hepatocytes. University of Groningen.
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Development of MAPC derived induced endodermal
progenitors
Generation of pancreatic beta cells and hepatocytes
Rangarajan Sambathkumar
2
Development of MAPC derived induced endodermal progenitors
Rangarajan Sambathkumar
Dissertation university of Groningen, the Netherlands
ISBN (printed): 978-‐90-‐367-‐9527-‐2 ISBN (digital): 978-‐90-‐367-‐9526-‐5 Cover page design/Layout: Adobe stock Standard License: #123133707
Printed by: ACCO DRUKKERIJ, Herent, Belgium, 3020
Copyright © 2016 by Rangarajan Sambathkumar
No part of this book may be reproduced or transmitted in any form or by any means without a permission of the author. All rights reserved.
Development of MAPC derived induced endodermal
progenitors
Generation of pancreatic beta cells and hepatocytes
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof.E.Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday 30 January 2017 at 09.00 hours
by
Rangarajan Sambathkumar
born on 10 January 1987 in Kallakurichi, Tamil nadu, India
Example title page
Educational Research
The behaviour of students
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Monday 5 March 2013 at 15.00 hours
by
Maria Anna Happy born on 23 July 1965 in München, Germany
4 Supervisors Prof. P. de Vos Prof. C.M.Verfaillie Co-supervisor Dr. M.M. Faas Assessment Committee Prof. A.J.W. Scheurink Prof. M.C. Harmsen Prof. T.P. Links Prof. A. Zwijsen
6
Paranymph
Sandra Smink
Renate Akkerman
Table of contents
Chapter 1: General Introduction and background 8
Chapter 2: Rationale and Objectives of the Research 84
Chapter 3: Human induced Endodermal Progenitors derivation
& Characterization from Multipotent Adult Progenitors 90
Chapter 4: In vivo and In vitro differentiation of iENDO cells
Into hepatocytes and endocrine pancreatic like cells 115
Chapter 5: Epigenetic induction of definitive and pancreatic endoderm
cell fate in human fibroblasts 154
Chapter 6: General Conclusions and future perspectives 177
Appendices: A Thesis Summary 184 B Samenvatting 187 C Abbreviations 191 D Acknowledgements 202 E Curriculum vitae 208
