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University of Groningen

Machine learning for identifying patterns in human gait

Zhou, Yuhan

DOI:

10.33612/diss.159240405

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Zhou, Y. (2021). Machine learning for identifying patterns in human gait: Classification of age and clinical

groups. University of Groningen. https://doi.org/10.33612/diss.159240405

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Machine learning for identifying

patterns in human gait

Classification of age and clinical groups

M

achine l

earnin

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or i

de

ntif

yin

g p

att

erns in h

uma

n g

ait

YUH

AN

ZH

O

U

YUHAN ZHOU

INVITATION

for attending the public

defense of the thesis entitled

Machine learning for

identifying patterns

in human gait

Classification of age

and clinical groups

by

Yuhan Zhou

y.zhou01@umcg.nl

On Wednesday 17 March 2021,

at 12.45 p.m.

In the Academy Building of

the University of Groningen.

Broerstraat 5, Groningen

YUHAN ZHOU

Paranymphs

Xiaoping Zheng

x.zheng@umcg.nl

Lisanne Bakker

l.b.m.bakker@umcg.nl

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The studies described in chapters 2, 3 and 4 were conducted at the Department of Human Movement Sciences, University Medical Center Groningen, Groningen, the Netherlands. The study described in chapter 5 was conducted at the Department of Human Movement Sciences, University Medical Center Groningen, Groningen, the Netherlands and the Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kindom.

This study was financially supported by the Keep Control program, which received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 721577.

PhD training was facilitated by Research Institute School of Health Research (SHARE), part of the Graduate School of Medical Science Groningen.

The printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen and Research Institute SHARE.

Paranymphs: Xiaoping Zheng Lisanne Bakker

Cover image: Uthai pr, shutterstock.com

Layout and design: Daniëlle Balk, persoonlijkproefschrift.nl Printing: Gildeprint Enschede, gildeprint.nl

ISBN: 9789464191431

Machine learning for identifying patterns in human gait: Classification of age and clinical groups Yuhan Zhou

Copyright © 2021 Yuhan Zhou

All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic and mechanical, including photocopying, recording or any information storage or retrieval system, without written permission from the author.

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3

Machine learning for identifying

patterns in human gait

Classification of age and clinical groups

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 17 March 2021 at 12.45 hours

by

Yuhan Zhou

born on 18 January 1990 in Jiangsu, China

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4

Supervisors

Prof. C.J.C. Lamoth Prof. T. Hortobágyi

Assessment Committee

Prof. A. Daffertshofer Prof. N.M. Maurits Prof. E. Otten

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TABLE OF CONTENTS

Chapter 1 General introduction 7

Chapter 2 The detection of age groups by dynamic gait outcomes using machine

learning approaches 21

Zhou, Y., Romijnders, R., Hansen, C., van Campen, J., Maetzler, W., Hortobágyi, T., Lamoth, C.J.C. (2020). Scientific reports, 10(1), 1-12.

Chapter 3 Artificial neural network accurately classified cognitively impaired

and intact geriatric patients using a combination of gait and clinical characteristics

45 Zhou, Y., van Campen, J., Hortobágyi, T., Lamoth, C.J.C., submitted for publication

Chapter 4 Classification of neurological patients to identify fallers based on

spatial-temporal gait characteristics measured by a wearable device 65

Zhou, Y., Zia Ur Rehman, R., Hansen, C., Maetzler, W., Del Din, S., Rochester, L., Hortobágyi, T. Lamoth, C.J.C. Sensors, 2020; 20(15):4098.

Chapter 5 Gait analysis with wearables can accurately classify fallers from

non-fallers: a step toward better management of neurological disorders 87

Zia Ur Rehman, R., Zhou, Y., Del Din, S., Alcock, L., Hansen, C., Guan, Y., Hortobágyi, T., Maetzler, W., Rochester, L., Lamoth, C.J.C. Sensors. 2020; 20(23):6992. (equal first authors)

Chapter 6 General discussion 113

Appendix A Summary 128

Samenvatting 131

概要 134

Acknowledgements 136

About the author 139

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