Table1: d r r r Systematcallyselecteclinicallyelevantvaiantalleleswhichefectthecompletesetof d r d ractonableDPWGguielines(58vaiantalleleslocatein14phamacogenes)Genes

(1)

Table 1: Systematcally selecte clinically elevant va iant alleles which efect the complete set of d r r r

d r d r

actonable DPWG gui elines (58 va iant alleles locate in 14 pha macogenes)

Genes Va iantr allele

Allele Functonal Status D ug fo which actonable DPWGr r

d

gui eline is available CYP2B6 *6 Dec ease functon o No functonr d r Efavi enzr

*9 Dec ease functon o No functonr d r

*5 Dec ease functon o Full functonr d r

CYP2C9 *2 Dec ease functonr d Phenytoin

r r Wa fa in

*3 Dec ease functonr d

CYP2C19 *2 No functon Clopi og eld r

r Citalop am

r Escitalop am

r r Se t aline

r Imip amine

r Lansop azole

r Omep azole

r Pantop azole

r

Vo iconazole

*3 No functon

*4A/B No functon

*5 No functon

*6 No functon

*17 Inc ease functonr d

CYP2D6 *xN Inc ease functonr d Amit iptyliner

r r A ipip azole Atomoxetne

r Clomip amine

d Co eine Doxepin Eliglustat

d Flecaini e

r d Halope i ol

r Imip amine Metop ololr

r r No t iptyline

r Pa oxetne

d Pimozi e

r

P opafenone Tamoxifen

r d

T ama ol Venlafaxine Zuclopenthixol

*3 No functon

*4 No functon

*5 No functon

*6 No functon

*8 No functon

*14A Dec ease functonr d

*14B Dec ease functonr d

CYP3A5 *3 No functon Tac olimusr

*6 No functon

*7 No functon

DPYD *2A No functon 5-Fluo ou acilr r

Capecitabine r Tegafu

*13 No functon

2846A>T Dec ease functonr d 1236G>A Dec ease functonr d

F5 1691G>A Dec ease functonr d Est ogen cont aceptve agentsr r

HLA-A *3101 High- isk alleler Ca bamazepiner

HLA-B *1502 High- isk alleler Ca bamazepiner

r Oxca bazepine

(2)

Phenytoin r Lamot igine

*1511 High- isk alleler Ca bamazepiner

*5701 High- isk alleler Abacavir

Flucloxacillin

*5801 High- isk alleler Allopu inolr

NUDT15 *2 Dec ease functonr d 6- e captopu ineM r r r Azathiop ine Thioguanine

*9 Dec ease functonr d SLCO1B1 *5/*15/*1

7

r d

Dec ease functon Ato vastatnr

Simvastatn M

TP T *2 No functon 6- e captopu ineM r r

r Azathiop ine Thioguanine

*3A No functon

*3B No functon

*3C No functon

UGT1A1 *6 Dec ease functonr d I inotecanr

*37 Dec ease functonr d VKORC1 -1639G>A;

1173 C>T

r d r

Dec ease exp ession Acenocouma olr

r

Phenp ocoumon r r

Wa fa in

CYP : Cytoch ome P450; r DPYD: Dihy opy imi ine Dehy ogenase; dr r d dr F5 : Facto V Lei en; HLA r d : Human Leucocyte Antgen; NUDT: Nu ix Hy olase; d dr SLCO : Solute Ca ie O ganic Anion T anspo te ; UGT :UDP- rr r r r r r

Table1: d r r r Systematcallyselecteclinicallyelevantvaiantalleleswhichefectthecompletesetof d r d ractonableDPWGguielines(58vaiantalleleslocatein14phamacogenes)Genes

Table 1: Systematcally selecte clinically elevant va iant alleles which efect the complete set of d r r r

d r d r

actonable DPWG gui elines (58 va iant alleles locate in 14 pha macogenes)

CYP : Cytoch ome P450; r DPYD: Dihy opy imi ine Dehy ogenase; dr r d dr F5 : Facto V Lei en; HLA r d : Human Leucocyte Antgen; NUDT: Nu ix Hy olase; d dr SLCO : Solute Ca ie O ganic Anion T anspo te ; UGT :UDP- rr r r r r r

r r r

glucu onosylt ansfe ase; TP T M : Thiopu ine S-methylt ansfe ase; r r r VKORC : Vitamin K Epoxi e Re uctase d d

Complex.