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University of Groningen Studies on Superantigens and Antibody Directed Enzyme Prodrug Therapy for Tolerable Targeted Cancer Treatment Bashraheel, Sara

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University of Groningen

Studies on Superantigens and Antibody Directed Enzyme Prodrug Therapy for Tolerable Targeted Cancer Treatment

Bashraheel, Sara

DOI:

10.33612/diss.96169444

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Bashraheel, S. (2019). Studies on Superantigens and Antibody Directed Enzyme Prodrug Therapy for Tolerable Targeted Cancer Treatment. University of Groningen. https://doi.org/10.33612/diss.96169444

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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185

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Chapter 10: Appendix

186

Conferences

• Experimental Biology 2014 (CA, USA)

Poster title: Functional overexpression and purification of a codon optimized synthetic four superantigens in Escherichia coli.

• ARC14 (Qatar)

Poster title: Cloning, Overexpression and Molecular Characterization of Four Superantigens: production of protein therapeutics for cancer treatment.

• ADLQ Junior symposium 2014 (Qatar)

Oral Presentation Title: Protein engineering of superantigens for the production of novel variants with improved safety and efficacy for cancer immunotherapy.

• Protein and antibody Engineering Summit 2015 (Lisbon, Portugal)

Poster title: Production of Novel Variants of Superantigens for Efficient Cancer Treatment.

• ADLQ Junior symposium 2015 (Qatar)

Oral Presentation Title: Production of novel tumor-selective Superantigens with improved safety and efficacy for cancer immunotherapy.

• Protein and antibody Engineering Summit 2016 (Lisbon, Portugal)

Poster title: Production and Molecular Characterization of Superantigenicity-Positive Lethality-Negative Superantigens for Cancer Treatment.

• ADLQ Junior symposium 2016 (Qatar)

Oral Presentation Title: Production of Lethality-Negative Superantigenicity-Positive Superantigen Molecule for Cancer Immunotherapy.

• Immuno-Oncology Summit 2017 (Canary Wharf, UK)

Poster title: Superantigens: Production of Superantigenicity-Positive Lethality-Negative Molecules for improved safety and efficacy of cancer immunotherapy.

• ADLQ Junior symposium 2017 (Qatar)

Oral Presentation Title: Tumor Targeted Superantigens: Production of novel variants therapeutics.

• ADLQ Junior symposium 2018 (Qatar)

Poster title: Studies on Superantigens and Superantigen-derived Peptides for Tolerable Cancer Immunotherapy.

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187

Acknowledgements

الله لوسر َلاَق

:

"

َساهنلا ُرُكْشَي َلا ْنَم َ هاللَّ ُرُكْشَي َلا

"

The Prophet, peace and blessings be upon him, said, “The one who doesn't thank people, doesn't thank God”. Therefore, I would like to express my deepest gratitude to all the people who helped me throughout my PhD years.

I would like to express my sincere gratitude and appreciation to my supervisors

Prof. Sayed K Goda and Prof. Alexander Dömling for their continuous help

and support. Thank you for the great collaboration and the PhD program you initiated between Antidoping Lab Qatar (ADLQ) and the University of Groningen (UG).

Prof. Goda, I cannot thank you enough for the immense knowledge, guidance,

and encouragement I received from you. Pursuing a PhD was never in my dreams; it is your trust and belief in my capabilities that pushed me to achieve this degree. Even though I had a very tough journey, I always felt fortunate to be part of your group and to work under your supervision. Thank you for all the help and support you provided even with your extreme health condition. You have been an amazing supervisor, father, and friend. I hope one day to inspire someone else as you have inspired me. May Allah bless you with good health and long life.

I’m grateful to Prof. Dömling for allowing me to pursue my PhD and be part of his team at UG. Thank you for always being generous and facilitating my work. You are always there when most needed. It has been great working with you and I hope I will have the chance to collaborate with you in the future.

I would like to thank Prof. Mohammed Almaadheed, the Chairman of BOT of ADLQ, for initiating a postgraduate program at ADLQ.

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Chapter 10: Appendix

188

My sincere appreciation to Dr. Mohammed Alsayrafi, former General Manager of ADLQ, for his continuous support and concern to empower Qatari youth. Thank you for allowing me to pursue my PhD studies. I will always remember your weekly rotations among the labs and offices talking to us about our needs and concerns. I will also remember how easy it was to approach you when we needed help. Thank you for all the help, facility, and support I got from you.

A special thanks to my partner in this journey Dr. Alanod Al Qahtani. Thank you for sharing the struggles and pleasures with me and making this experience fun. It has been great working with you, and I hope to work with you again in the future. Best wishes for your bright future.

I would like to give an exceptional thanks to my friend and colleague Haya

Al-Sulaiti for being supportive, understanding, and bearing with me at all times.

Thank you for always being there when I needed the most. It is amazing to see how you progress and work hard to achieve your goals on both personal and professional level. I need to learn a lot from you in life. I’m sure you will be a great influencer one day. Best wishes for your career.

I would like to express my sincere appreciation to Dr. Mohamed El-Rayess for his continuous help and support. You are not only a very good scientist who is very generous in his scientific help but also a very good friend. Thank you for always being there for me. I wish you all the success in your new position.

My appreciative thanks are also extended to my seniors in ADLQ, Dr. Nelson

Orie, Dr. Sven Voss and Dr. Morana Jaganjac for helping me in some of the

techniques involved in the work.

I would like to thank my fellows in Protein Engineering Lab at ADLQ for their companionship and for maintaining a good working environment. I also want to thank the Phlebotomy and Staff Clinic members for the facilities and the help they provided.

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189 I would like to thank Prof. David O’Conner for making the time for proofreading some of my papers, and our lab manager in UG, André Boltjes, for translating my PhD thesis summary to Dutch.

I would like to acknowledge QNRF and ADLQ for funding my project and UG for facilitating and supporting the work.

I would like to thank all my friends for their unconditional friendship, support and patience throughout my PhD years.

Last but not least, I would like to thank my family for supporting me throughout my life. Thank you mom and dad for being the best ever; without your support and motivation it would not have been possible to attain this level of education. Thanks to my sisters and brothers for their unconditional love and support.

Thank you all

َمْعَنَب يَذهلا َ ه َلِلّ ُدْمَحْلا

تاَحَلاهصلا ُّمَتَت َهَت

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