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University of Groningen Studies on Ligand Directed Enzyme Prodrug Therapy and Production of Long Acting Protein Therapeutics for Targeted Cancer Treatment Al-Mansoori, Layla

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University of Groningen

Studies on Ligand Directed Enzyme Prodrug Therapy and Production of Long Acting Protein Therapeutics for Targeted Cancer Treatment

Al-Mansoori, Layla

DOI:

10.33612/diss.131689831

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Al-Mansoori, L. (2020). Studies on Ligand Directed Enzyme Prodrug Therapy and Production of Long Acting Protein Therapeutics for Targeted Cancer Treatment. University of Groningen.

https://doi.org/10.33612/diss.131689831

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Propositions

Belonging to the thesis

Studies on Ligand Directed Enzyme Prodrug Therapy and

Production of Long Acting Protein Therapeutics for Targeted

Cancer Treatment

1- “Targeted cancer therapy ensures proper biodistribution of the chemotherapeutic agent,

thus selective killing of cancer cells.” (This Thesis)

2- “Over every possessor of knowledge is one [more] knowing” (Holy Quran Surah

Yusuf-76)

3- “Because of the dual benefits of CPG2 in cancer treatments, it is considered an enzyme of

great potential in this area of research.” (This Thesis)

4- “Insanity is doing the same thing over & over again & expecting different results.”

(Albert Einstein)

5- “Man is either your brother in faith or your equal in humanity.” (Ali Ben Aboutaleb) 6- “APN is a cancer cell marker known to have a major role in cancer cell invasion and

angiogenesis. It is highly expressed on the cell surface in various solid tumors but generally has low levels of expression in normal cell types.” (This Thesis)

7- “You don't have to see the whole staircase, just take the first step”. (Martin Luther King,

Jr.)

8- “PEGylation induces various forms of conformational changes when PEG is conjugated

with the protein; such structural changes have proven to affect protein stability, binding and catalytic activity.” (This Thesis)

9- “It is not eyes that are blinded, but blinded are the hearts” (Holy Quran Surah

AL-Haj-46).

10- “No two things have been combined better than knowledge and patience.” (Prophet Muhammad “peace be upon him”)

Layla J R Al-Mansoori

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This journey was very exceptional and long for me, many people came into my way throughout my study, and had a very supportive influence, I would love to express my gratitude to