University of Groningen
Studies on Superantigens and Antibody Directed Enzyme Prodrug Therapy for Tolerable Targeted Cancer Treatment
Bashraheel, Sara DOI:
10.33612/diss.96169444
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Bashraheel, S. (2019). Studies on Superantigens and Antibody Directed Enzyme Prodrug Therapy for Tolerable Targeted Cancer Treatment. University of Groningen. https://doi.org/10.33612/diss.96169444
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Studies on Superantigens and
Antibody Directed Enzyme Prodrug
Therapy for Tolerable Targeted
Cancer Treatment
The research described in this thesis was performed in the Protein Engineering Lab, Research Department, at Anti-Doping Laboratory Qatar (ADLQ). The work was financially supported by Anti-doping Lab Qatar (ADLQ) and Qatar National Research Fund (QNRF) NPRP6-065-3-012, Doha, Qatar.
The author gratefully thanks QNRF for funding part of this work and University of Groningen (UG) and Anti-Doping Laboratory Qatar for facilitating the research and printing the thesis.
Cover picture: Shutterstock
Cover design: Aspire Printing Press Printed by: Aspire Printing Press
©2019, Sara S Bashraheel.
All rights reserved. No parts of this thesis may be reproduced or transmitted in any form, by any means, without prior written permission from the author.
ISBN: 978-94-034-1909-1 (printed version) ISBN: 978-94-034-1908-4 (electronic version)
Studies on Superantigens and
Antibody Directed Enzyme Prodrug
Therapy for Tolerable Targeted
Cancer Treatment
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Friday 20 September 2019 at 11.00 hours
by
Sara Bashraheel
born on 1 July 1989 in Doha, Qatar
Supervisors
Prof. A.S.S. Dömling Prof. S.K. Goda
Assessment Committee
Prof. L. Chouchane Prof. F. Kuipers Prof. M. Schmidt
Thesis Content:
Chapter 1: Introduction to the Thesis ... 7
Chapter 2: Update on Targeted Cancer Therapies, Single or in Combination, and their Fine Tuning for Precision Medicine ... 15
Chapter 3: Studies on Vascular Response to Full Superantigens and Superantigen Derived Peptides: possible production of novel superantigen variants with less vasodilation effect for tolerable cancer immunotherapy ... 53
Chapter 4: Isolation and Molecular Characterization of Novel Glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment ... 79
Chapter 5: Production of “biobetter” variants of glucarpidase with enhanced enzyme activity ... 113
Chapter 6: Production of “biobetter” glucarpidase variants to improve Drug Detoxification and Antibody Directed Enzyme Prodrug Therapy for Cancer Treatment ... 139
Chapter 7: Summary and Future Prospects ... 171
Chapter 8: Samenvatting en Toekomst Perspectieven ...175
Chapter 9: ةيلبقتسملا ةيؤرلاو صخلملا ...181
Chapter 10: Appendix ... 185
Conferences ... 186
