University of Groningen
Production of novel protein therapeutics to improve targeted cancer therapy Al-Qahtani, Alanod
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Publication date: 2019
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Al-Qahtani, A. (2019). Production of novel protein therapeutics to improve targeted cancer therapy. University of Groningen.
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Production of Novel Protein
Therapeutics to Improve Targeted
Cancer Therapy
The research described in this thesis was financially supported by Qatar National Research Fund (QNRF) NPRP6065-3-012, Doha, Qatar.
The author gratefully thanks Groningen University and Anti-Doping Laboratory Qatar for facilitating and supporting the research, and Makery for printing the thesis.
Al-Anod D Al-Qahtani
Cover picture: Giovanni Cancemi/Shutterstock.com Cover layout: Al-Anod Al-Qahtani
2018, Al-Anod Al-Qahtani, Doha, Qatar.
©All rights reserved. No parts of this thesis may be reproduced or transmitted in any form, by any means, without prior written permission from the author. ISBN: 978-94-034-1415-7 (Ebook)
Production of Novel Protein
Therapeutics to Improve Targeted Cancer
Therapy
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. E. Sterken and in accordance with the decision
by the College of Deans.
This thesis will be defended in public on
Monday 13 May 2019 at 11.00 hours
by
Alanod Dashin M F Al-Qahtani
born on 23 September 1986 in Doha, Qatar
Supervisors
Prof. A.S.S. Dömling
Prof. S.K. Goda
Assessment Committee
Prof. L. Chouchane Prof. P.H. Elsinga
Prof. F. Kuipers
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﴿
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Table of Contents:
Chapter 1 General introduction and scope of the thesis 11
Chapter 2 Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment.
19
Chapter 3 Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro drug therapy for cancer treatment
69
Chapter 4 Production of “biobetter” variants of glucarpidase with enhanced
enzyme activity
107
Chapter 5 Production of “biobetter” glucarpidase variants to improve Drug Detoxification and Antibody Directed Enzyme Prodrug Therapy for Cancer Treatment
139
Chapter 6 Studies on Vascular Response to Full Superantigens and superantigen Derived Peptides: Discovery of novel potential antihypertensive peptides and possible production of novel superantigen variants with less vasodilation effect for tolerable cancer Immunotherapy.
179
Chapter 7 Summary and future prospective 211
Chapter 8 Nederlandse Samenvatting 217
Chapter 9 Arabic Summary
223 Chapter 10 Appendix • Proposition • Conferences • Acknowledgment 229 231 233 235
