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Cover Page

The handle

http://hdl.handle.net/1887/70477

holds various files of this Leiden University

dissertation.

Author: Ruiter, K. de

Title: Immune modulation by helminths and the impact on the development of type 2

diabetes

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IMMUNE MODULATION BY HELMINTHS AND

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ISBN: 978-94-6182-936-8 © 2019 Karin de Ruiter

The work presented in this thesis was performed at the Department of Parasitology, at the Leiden University Medical Center, in collaboration with the Department of Parasitology at the Faculty of Medicine of University of Indonesia, Jakarta.

The studies described in this thesis were financially supported by The Royal Netherlands Academy of Arts and Science (KNAW).

Cover design and artwork: Evelien Jagtman (www.evelienjagtman.com) Layout and Printing: Off Page, Amsterdam (www.offpage.nl)

IMMUNE MODULATION BY HELMINTHS AND

THE IMPACT ON THE DEVELOPMENT OF TYPE 2 DIABETES

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op dinsdag 26 maart 2019

klokke 15.00 uur

door

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Promotores

Prof. Dr. M. Yazdanbakhsh

Prof. Dr. T. Supali (Universitas Indonesia, Jakarta, Indonesia)

Co-promotor

Dr. B. Guigas

Leden promotiecommissie

Prof. Dr. P.C.N. Rensen Prof. Dr. M.J. Jager Prof. Dr. C.H. Hokke

Prof. Dr. A.G.M. Tielens (Utrecht University)

Dr. J. Hendriks (The Janssen Pharmaceutical Companies of Johnson & Johnson)

TABLE OF CONTENTS

Chapter 1 GENERAL INTRODUCTION 7

Chapter 2 Helminth infections and type 2 diabetes: a cluster-randomized 19 placebo controlled SUGARSPIN trial in Nangapanda,

Flores, Indonesia

Chapter 3 Effect of anthelmintic treatment on insulin resistance: a cluster- 37 randomized, placebo-controlled trial in Indonesia

Chapter 4 The Schistosoma mansoni glycoprotein omega-1 improves 59 whole-body metabolic homeostasis independent of

its Th2 polarizing capacity

Chapter 5 A field-applicable method for flow cytometric analysis of 83 granulocyte activation: Cryopreservation of fixed granulocytes

Chapter 6 The effect of helminths on granulocyte activation: 105 a cluster-randomized placebo-controlled trial in Indonesia

Chapter 7 The effect of three-monthly albendazole treatment on 127 Th2 responses: Differential effects on IgE and IL-5

Chapter 8 Effect of deworming on type 2 and regulatory responses 143 revealed by mass cytometry

Chapter 9 Summarizing discussion 175

Appendices Nederlandse samenvatting 191

Acknowledgements / Dankwoord 198

Curriculum vitae 200

Referenties

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