• No results found

Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design

N/A
N/A
Protected

Academic year: 2021

Share "Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)University of Groningen. Reappraisal of Atrial fibrillation Gilbers, M. D.; Bidar, E.; Maesen, B.; Zeemering, S.; Isaacs, A.; Crijns, H.; van Gelder, I.; Rienstra, M.; Verheule, S.; Maessen, J. Published in: Netherlands Heart Journal DOI: 10.1007/s12471-021-01538-x IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.. Document Version Publisher's PDF, also known as Version of record. Publication date: 2021 Link to publication in University of Groningen/UMCG research database. Citation for published version (APA): Gilbers, M. D., Bidar, E., Maesen, B., Zeemering, S., Isaacs, A., Crijns, H., van Gelder, I., Rienstra, M., Verheule, S., Maessen, J., Stoll, M., & Schotten, U. (2021). Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design. Netherlands Heart Journal. https://doi.org/10.1007/s12471021-01538-x. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.. Download date: 24-06-2021.

(2) 01232456718296

(3) 8  234718296.  !"#$!#$$%#&'%#($&#($#)*+(,. - 5..15256/0781256121266582/43248 15982/42 84. 4 5. 16/53 6522628786 98129561 9/ 6624354:59 651  852262582/42485 .1/31 2/4/07;<-768:=>2. ?54@A1/B 9838  234 CDDE262 1 F8D?251F?DC5  4F

(4) DG. 9 1243F7DH559FID612B4FHDJ54E 6 1FCD-2 4815F

(5) D: 15 6 FKDC5  4FCD

(6) 8/66FLD

(7) 95/88 4 MNN#&OPQ&$&# RSMPTU&$&#. VWXYZ[\Y ]^_`abcdef ghijikilmnoipqmrsqtuslvwtullsqump xyz{u|s}monli~olqurs}qmtuslntm}i||€kitqhi ns|qri‚ji}sji|ƒo}hhs|wiiplistpijswmqqhi nsqhmnh„|umlm u}slntm}i||i|qhsq}splisjqmyzrtmo skstuiq„mr|ni}uv}ju|is|iomjil|upspuosl|€†m‚‡ ikitƒmtswuluq„qmti}m pu|iqhi|iju|is|intm}i||i| upyznsquipq|u||qullluouqijƒ‚hu}hhs|}mpqtuwqij qmqhiluouqijntm ti||upuontmkup th„qho }mpqtml upyz€ ˆ‰Š‹ŒcŽ_‰‘‹’iwiluikiqhsqswiqqitpjit|qspj‡ up spjjiqi}qumpmrqhiupjukujslnsqhmnh„|umlm u}sl “€”€•ulwit|x– {—˜€™ujst—™€“si|ip—š€“si||ip ”instqoipqmr›stjumqhmts}u}œt it„ƒ“ss|qtu}hq pukit|uq„“iju}sl›ipqtiƒ“ss|qtu}hqƒghižiqhitlspj| ostquŸp€ ulwit| oo}€pl “€”€•ulwit|—œ€¡iioitup —y€¢|ss}|—œ€£ithili— “€œqmll—€œ}hmqqip ›stjumks|}lst¤i|ist}h¢p|quqqi“ss|qtu}hqƒpukit|uq„mr “ss|qtu}hqƒ“ss|qtu}hqƒghižiqhitlspj| y€¢|ss}| ”instqoipqmr¥h„|umlm „ƒpukit|uq„mr“ss|qtu}hqƒ “ss|qtu}hqƒghižiqhitlspj| “€œqmll ¢p|quqqimr†osp•ipiqu}|ƒpukit|uq„mr“¦p|qitƒ “¦p|qitƒ•itosp„ y€¢|ss}|—“€œqmll ”instqoipqmr™um}hiou|qt„ƒ•ipiqu}˜nujioumlm „spj œqsqu|qu}sl•ipiqu}|ƒpukit|uq„mr“ss|qtu}hqƒ“ss|qtu}hqƒ ghižiqhitlspj| †€›tuŸp| ”instqoipqmr›stjumlm „ƒ“ss|qtu}hqpukit|uq„“iju}sl ›ipqtiƒ“ss|qtu}hqƒghižiqhitlspj| ¢€ksp•iljit—“€¤uip|qts ”instqoipqmr›stjumlm „ƒpukit|uq„mr•tmpup ipƒ •tmpup ipƒghižiqhitlspj|. oi}hspu|o|pjitl„up yzu|sntiti§u|uqirmtjikil‡ mnup nsquipq‡qsulmtijqhitsnui|€ghi¤y›˜£gu||i ™sp¨¥tmŸi}q‚ull}mpqtuwqiqmqhiptskillup mrqhi osupomli}lstoi}hspu|o|mryzw„|qj„up hu|‡ qmlm „spj ipmoi‡‚uji¤žyi~nti||umpntmvli|spj }mowupup qhu|uprmtosqump‚uqhjiqsulijnhipmq„n‡ up mrnsquipq|pjit mup }stjus}|t it„€ ©ªcf‹y|omtispjomtiikujip}i| i|q|qhsq yzos„m}}tpmqmpl„jtup qhivt|qjs„|wqsl|m jtup qhiompqh|spj„ist|srqit|t it„ƒ‚i‚ull|„|‡ qiosqu}sll„|qj„qhiup}ujip}imryzjtup qhivt|q „ist|srqit}stjus}|t it„upnsquipq|‚uqhmt‚uqhmq shu|qmt„mryz€™mqhqhimkitsllyzwtjips|‚ills| qhinsqqitpmryzinu|mji|‚ullwi|qjuij€«s|ql„ƒ‚i ‚ull|qj„qhis||m}usqumpwiq‚iipqhiosŸmtomli}‡ lstoi}hspu|o|spjqhi}lupu}slnti|ipqsqumpmrqhi nsquipq|ƒup}ljup qhiup}ujip}ispjnsqqitpmryz jtup qhirmllm‚‡nnitumj€ ¬ce_­d‹‰ce ghi¤y›˜£gu||i™sp¨¥tmŸi}q}mo‡ wupi|jiinnhipmq„nup mrnsquipq|pjit mup }st‡ jus}|t it„ƒup}ljup th„qho rmllm‚‡nƒspsl„|u| mromli}lstoi}hspu|o|ƒhu|qmlm u}slspsl„|u|spj ipmoi‡‚uji¤žy|i§ip}up €ghu|snntms}h‚ull ntmkujijiqsulijup|u hq|upqmqhiosupnsqhmlm u}sl slqitsqump|s||m}usqij‚uqhyzupsqtuslqu||ispj qhitiw„}mpqtuwqiqmqhijikilmnoipqmrupjukuj‡ slu|ijƒoi}hspu|qu}sll„ uprmtoij nsquipq‡qsulmtij qtisqoipqrmtyz€ ®¯°±²Z³Xyqtuslvwtullsqump—¥m|qmnitsqukisqtusl vwtullsqump—gtsp|lsqumpslti|ist}h—›stjus}qu||i— œqj„ji|u p. H481/ 982/4 yqtuslvwtullsqumpxyz{u|qhiom|q}moomp}stjus} stth„qhousupsjlq|spjs||m}usqij‚uqhsq‚m‡qm qhtiirmljup}tis|ijtu|¨mr}stjumks|}lstikipq|€ghi ¤isnntsu|slmrsqtuslvwtullsqump.

(8) 01232456718296

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

(10) 8  234 WXYZ[\Y]^]_`XYZ^\X\a^b[cbZ[d > 7448 74("-80--888-( 7+> "--4 74  7!-4-(47 -#34("- -B0 84 -)+%4 B7 - 74+<7)228("-!70 #228"-7-4./(%28 "-6"8B4./=>./@(%28"6"8./+,!+# -" -- 7- 74+ e5R6 f ghijhkilmnoppqorosortijiqqujkvsmujwruqxy zjim{ijorkhipx|}]c[~€{ijm{ijorkhipx|}‚ƒ€nmppml„u{hkw„ krwonrij |}† €ovq‡yˆ|}‚‡yˆ€xiojw •–—˜—™š–›—œž‹Ÿ ¡›Ÿœ—™š–Œ¢š£—˜š—ž˜ ¤¢Œ˜¥Œ¥¥—¦——œŒ¥Œ–Œ™‹ž™š‹¥—ž¦‹š£ §–žž¥¨—ž£š‹©Œ‹œ ¤™›ž™š‹¥—ž¦‹šŠ›Ÿ ªšœ™«–š‹šœœŒœœ£Œ˜ ¬«Œœ—ž˜˜š—‹Œœ ­ž®¯¥žœŒ™š‹¥—š™•‰ •š‹¥—š™¨—žŠœ—Œœ Ž›Ÿ›££ž˜—ž‹—˜¦. ‰Š‹ŒŽ ‰              .  . ‰‘          . ‰’“”            .

(11) 01232456718296

(12) 8  234718296.   !"#"!$%&'()*+%&,#$%"%'%&-$. ,/012(!3!-4565.&!#71$8&9!$ !&+:!&;%< .=>?@ABC D!"#"!$%&-'!*(" '%E'$%*!$'),/012'$#+%'C,(!3!-8'%& @C>>C@CFC5.'!&!"6''7()*+%$L.!&G$*"6 '$%&-&$H;8!"#$.'."+4HI>CJK@?F7'.+$.!$. !&!$%!"ØÙ%""!$%&-#()J?(!$%&$'%& *; (!%'&$!'%&#'.6$.* -#()@??!.%8+ -!$$.!&Ú?Û($+$$!)"+ .!&-I@CÜJ 8&)!"6G(''+$!&'%($'!&+&!"6@??Û ()"!-))$'4'Ý%-C@FCÝ *(!%'&' Ù$&$(!$%&$-#(' *(%'%&-J?(!$%&$' !.7Ú?Û(!'!.+))"+ .!&-'I@CÜJ )*!Ù#&+!&$"6$!&'%Ù+-&'7!&+ "'$. _`a`bcÿefghijakÿœ`€fÿf‚ƒ‚„  lmnm‡~ÿqrm‘tsqust‡un  }ŽÿsŒsŠr†Šm `€fÿf‚ƒ‚„ÿœ_`a`bcÿefghijak  }Žÿq†mrnsÿrm–†Šm‘ÿŠuÿmnm‡~ÿ ‘tžmrmn~ms. `€fÿf‚ƒ‚„ rmuqmr†‡ˆmÿ ‰m†rŠÿr‰‹Š‰zvÿ ~un‡nŒuŒsÿ r‰‹Š‰zÿ zuntŠurtnvÿ}Žÿ q†mrnvÿ}Žÿ Œr‘mn. _`a`bcÿefghijak lmnmÿ mpqrmsstunv mwxysvÿz{|}v zt~ru{|}. ’f“c“f€iÿf`„g”`iijakÿœ k`a`bcÿefghijak  ŸŠrŒ~ŠŒr†–ÿ~unsm Œmn~msÿ ušÿmnm‡~ÿ‘tžmrmn~ms  lmnm‡~ÿqrm‘tsqust‡un _`a`bcÿefghijakÿœ ¡f“c“f€iÿf`„g”`iijak  ¢m~‰†nts‡~ÿmpq–†n†‡unÿ šurÿsŠrŒ~ŠŒr†–ÿ ‘tžmrmn~ms. ’f“c“f€iÿf`„g”`iijak •m––Œ–†r—sŠrŒ~ŠŒr†–vÿ˜rustsvÿ ~†–~tŒzÿ‰†n‘–tnÿ tnsŠ†t–tŠ‹vÿ†qÿ™Œn~‡unÿ rmzu‘m––tnvÿ~m––Œ–†rÿ ‰‹qmrŠruq‰‹vÿš†‹ÿ tn˜–Šr†‡un. ›``eÿe‚`agƒe`. MNOPQORQÿTUVÿWNXRYZX[\RXZÿ]X^ ¥23¦§ ¨©ª«¬­®¯°±²±²³´²«µª«²¶±·«­¸±²±­´¸°´­¹³¬®º²»¼±ª½ ²®²¾±²·´¶±·«¯«´¶º¬«¯«²ª¶´²»­´¬»±´­ª±¶¶º«¿¼«¼±¸¸¸®®¹ ©®¬ÀÁÂ꽫­®¯°±²´ª±®²®©³«²«ª±­»´ª´®©°¸®®»´²»ª±¶¶º«±² ­®¯°±²´ª±®²¼±ª½»´ª´®²¶ª¬º­ªº¬´¸¬«¯®»«¸¸±²³¿¼½±­½¼®º¸» ³±·«±²¶±³½ª±²ª®ª½«»±©©«¬«²ª³«²«¶±²·®¸·«»±²¶ª¬º­ªº¬´¸¬«¾ ¯®»«¸¸±²³ÄÁÅ꽫Ʈ¶¶±°¸«´¶¶®­±´ª±®²®¬Æ¬«»±¶Æ®¶±²³¬®¸«. `€fÿf‚ƒ‚„ÿœ ’f“c“f€iÿf`„g”`iijak  }Žÿq†mrns  £~~Œrrmn~mÿušÿ £}Ž  {msqunsmÿŠuÿ sŒrt~†–ÿ†–†‡un ’f“c“f€iÿf`„g”`iijakÿœ `€fÿf‚ƒ‚„  ¤mrmmÿušÿsŠrŒ~ŠŒr†–ÿ rmzu‘m––tn  ¤tžmrmn~msÿtnÿ sŠrŒ~ŠŒr†–ÿ rmzu‘m––tn  }ŽÿsŒsŠr†Šmÿ. ®©¶ª¬º­ªº¬´¸¬«¯®»«¸¸±²³±²´ª¬±´¸Ç°¬±¸¸´ª±®²ÁÈÉô²»¨Ê»«¾ ·«¸®Æ¯«²ªÄÁË꽫»±©©«¬«²­«±²³«²«ª±­«µÆ¬«¶¶±®²±²´¶¶®¾ ­±´ª±®²¼±ª½»±©©«¬«²ªªÌÆ«¶®©¨Ê´²»ª½«³«²«ª±­¯´¬¹«¬¶©®¬ Ƭ«»±¶Æ®¶±ª±®²©®¬Æ®¶ª®Æ«¬´ª±·«´ª¬±´¸Ç°¬±¸¸´ª±®²ÁÍÎÈÉû«·«¸¾ ®Æ¯«²ªÏÐÑÒ«µÆ¬«¶¶±®²Óº´²ª±ª´ª±·«ª¬´±ª¸®­±¿ÔÕȯ«¶¾ ¶«²³«¬Öר ,!((!%'!")!$%!"ØÙ%""!$%&.

(13) 01232456718296

(14) 8  234718296. !"#$"% fg2.5O.Ofbh-.6/-O35e8 #$#&"$#'&&"()*"#$+$& B"#"$!*;$$&$!*#$&#"#$" $&$#*$'#$&$&#* $##'( !#$&$&#*#$&&#$"&:#*: "&#$&$&=#$&&#*"#$" &#'"#' ,-./0.-1234.0123.52671-162.-38123/5 = $&!#**#:$&!###$&"% 9#$&"'$&:$&$#$&#"$&$" *$#;:*;% #$"$='"&'"#$&ij()*J%BHI$#* $" <=$&#$& & >'#$&&$?)&# 9@ !&#&9@$!&$:'#=#$ A$#;A":BC%DE%DFG:&<#&$!$# "% $&#$!#$&'$&!= & &!"$&! #"$!= ?BHIG"$&!?J#&KL$% =$!*# $&=#$&&#*<$#&"& #$& :'#$&D=$&G:#&#*"$""*"% 9@'##ij( $!*;?))BG&"$""='##=!*; B"#"$!*$"=##=$&= ?H)G"&$ =( @'#*=: #*<#&$!$# D%BHI"$&!:=$&&# =$ #M&;'!;#* #$ k$#$&>'&";:$!&%!Y% #=$&#$&$=M##9@&9@ '#$&:$$&:=*!;&#$#=% !$&( N=$ '  =#$$$#;:$ "###*"$&% !&#;$&!( $":!&#$"&*$#!$" #$$&'#$&# '#$&(. ,.-/0.-1234.0-/6.OP-. E'$&!'!;:#*'!&=$$#% =#$'== #*$!*#& ##$'= &#* #&#$"()*#$'$&%+& #!#QRSH(E'$&!'!;:&$=&#  "?TFUG?U F$&>:V#&$":V$&&$: VW:XA9G$"'"'#&';( Y#$&#$#* "$"$=&#"#&$"$"$#*&#$ :"=#$$#*H$&MW#M?V#&$"G: $ &#"$&TFU$&""&#$&''*;#*==&% $#$&!$;$$#&%'# #*$"( ,/82/0.-1234.Z/[[/\]P0 E'$&!#* %'$J(D;:"&#$&'' *;#*==&$#$&!$ =$#*H$&M W#M(Y#$&#$ $&$###'& % '$$##;&J(D;##$;( 9##*%; ':"$&$" *$#;:>'#$&% &$&$!$# BHI$ #()#* "'##'#*#$&#:$&#$=%=$#*$"M% &$&#*"#$#;&'"$#; "'#$&$ ='( 9##*J(D%;  ':"$&$" *$#;:$!$# BHI:>'#$&&$:))B&=$&!$  #(9##*>'##*#$&#:#*TFU$  <#"#(  8526  912^82_4_`^582 489a51598 12582_4 b/5235P/P8-7c27dd/532/-35e H&#$&''=#=&$#$&!$$$#* H$&MW#M(B;&$!*#:&'#=#$"%'# #*$=&#$"#$#&=$##:&&" M:' ##**;#*=$&"&'"% #$&&=$#$$">'$()*$$&=#$&!$ $&$!*#$&#&;9@:"'&":##& &'&9@( U$#$k$#$&. ld1e35e A $=!$&!=$#$*&*&# '' $&$&#$;$&!$M"##*#"&#$'##& *;#*=!&$"'##(@#*$&:"' ='=&#: %"$"H)"&$#*'# "&##&))B$ =$& #$&#( m3/d1-n.-8Z/-op N=$&!$ =#$;& ###*J(D%; %'$$#(q!' $=M$&####=;"$ $&r';: $&s==#$&:""$'=*&$&!:"'#$$% #$&:k$&*;"!'$$#;itj( b1-O3162388P.671-162.-38123/5 uvwxyz{x|}~x~ 9#$ = $&!$#*"'&"&>'&" 9@iJ:Lj(€$#!$" <=$&#$&$&&$= &*'=&**&$#'"#' ##$& $&M#9@()$&#$!#$&#"##'"% #' ##$&:$ "=$&#**$#!$" &$=='&*$#"*=$" #$&$&!$&";"#$&( ‚u~ƒ„ †x ‡ UW9>'&"$&!$ '##=$&!&=% $<$&k$& #$ #$'=( )*$*;#*$%!&#$&!"*$  '# $&#$;$&#$ ;<#&"$#$&#$&# $#*&$#*'#9@&$&#$&#* 9@# %'()*$!&$:#*:  '##=$&&#&;*<$&"*&! "&>'&"9@'#*$"*<$&#% #&"$#$#*#*=&#9@# =$&!#*$$(.

(15) 01232456718296

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`a0 &)2=!b&& %&&''"&$ '*')& %&!)!%) !&!1$ (%!""*((#$'*!c/U&)! #")%&)(&% ))( *"&'!')((&()!&")  "&&')& ) ) & &%""$"!"'"$ ()())( %&&$#%&Vd, &;&/ 0" )''!)"#(('!.%&%&)(&%" "& '!&.)(&&*,-*((#)!%) !&!)%"#,)% !%& )!&(2&%(&()!&"$ ) "&!")%(&*)!)/0"& %#(()( '!.%&)()!&)**!)(&$ ()!')"#) %&!("&)')"()()(&!$ ) ) )&%#",-1"&)!*)(!&)%"&!)!$ %.)()!%&)& )!)( &)%"&!&$ !&"&%&.&('&*%.%)(&%1&")$ )((*!&%')&$)(!&%!&)&*!,-/ V&)''!))(*)!)(5!(().

(17) 01232456718296

(18) 8  234718296.  !""#$%&%'%%$(!)*%!$ +#)!#),-./'0123415678-9.:7%!""$!!(#;8$!(<&4 $((!#):)%$!=#)&% %%)"%$-#!>(!&(69(%=$=!( $%?#%(()>6!).!=(!$%!&(!#))%"$#>$%#) #;8+@A BCDEFCGFHIHJFKAL=#%)$%"#$#)#$!$!#$=#)(4 !)=;%%;$#? %K)M%$N%((!LMOO%$!P!(!)!,KLP@6 %K)M%$%#;K!!)-!(;#$)!,KL8@67#=%Q!>4 )#=,L O%$(!)@!)R#)#)SR#)#)AKAL=#%) =#4;#)%$!)!$%#(%$#;T#$7?=U.6!")4 #;;=#?"!)#;%K)M%$#;V!!$=AVAQAW(&%$6 9AU!$6UAV!%%)6LAX%%?%$)>68AP!!=6*A-$Y)6PAM!) W%(%$6VA7%)$!6LA.%$%(%6RAV!%%)!)VAL#(( %=(!$%!%!M%)#=#?"%)>)%$%A Z[H\EEHJJ!$=(%(=%)%)%$!-$%!M%-#?4 ?#)8$&#)3A1P)%$)!#)!(]=%)%6 ="%$? %6!$)>6!!"!#)6$&#)!)$%"$#=#)) !)?%?#$;#$?!6!(#)>!#>M%!""$#"$!%=$% #%#$>)!(!#$,@!)%#$=%6"$#M%!()^# %-$%!M%-#??#)(=%)=%6!))=!%;=!)>% %$% ?!%A%?!>%#$#%$$"!$?!%$!()!$=(% !$%)=(%)%!$=(%_-$%!M%-#??#)(=%)=%6)(% )=!%#%$ %)!=$%()%#%?!%$!(AP;?!%$!( )#)=(%)%!$=(%_-$%!M%-#??#)(=%)=%!) #$)%)%%)#"%$?%&!#$$%>(!#)#$ %`=%%%"%$?%%6# (()%%##&!)"%$?4 #)$%=(;$#?%=#"$>#(%$A#M% !=#"#; (=%)=%6M":aa=$%!M%=#??#)A#$>a(=%)%a&a3A1aA. b c 1 49 . 2AW#8L6*(%^9V6d(("e86%!(Ad$%M!(%)=%#;!>)#% !$!(<&$((!#))!(:)!#)!(?"(=!#);#$$? ?!)!>%?%)!)$#^%"$%M%)#):%8)=#!>(!#) !)7^+!=#$)8$!(+&$((!#),87P8@LAR8V8A 0112f0gh:0ij1khA 0AL!%$^]6l!)>U6d$%L76%!(A];%?%$^#;!$!(<&$(4 (!#)!==#$)>##"?!(6&#$%$()%6#$%(%M!%(%M%(#; $^;!=#$:=##$&!%#)(#)>)!(!!;$#? %+$!?)>!?*%!$LAUVRA012gfim2:^23hiA iA.!"%(RlAU#%?#>$!"#;?!)!>%)>A '!$%A 0121f3m3:himk30A 3Al!)%((d6-!$(#)8-6W!%M=Q6%!(AL#=#%=#)#?= ;!=#$!)?#$!()"!%) !$!(<&$((!#)n8. 7%!""$!!(#;!$!(<&$((!#). =##$)L %"$?!$=!$%A9$Rd&(=*%!(A 012gf0g:221ik5A hA]!d!$QR6L"%$8V6-$#&Pe6%!(Ad##"%$!M%!$!(<&4 $((!#)>)<=!)()=$%!%?#$!(6#"!($%!?4 #)6!)#"!(=#A8))#$!=L$>A0123f5g:h0jkiiA =#)hiiA mAL=#%)K6.%$%(%L6e$=#;d6W#%%8Ad!#"4 #(#>=!(?%=!)?#;!$!(<&$((!#):!$!)(!#)!( !""$!!(Ad#(7%MA0122f52:0mhki0hA jA9(()#$d6])%!e]68(&%$-V6%!(A V%!4!)!( %)<%`)% =%"&((#=;#$!$!(<&$((!#)A '!W%)%A0120f33:mj1khA gAL))%$V+6=^%$'76])%!e]6%!(AP)%>$!)>>%)%=6 $!)=$"#)!(6!);)=#)!(!)!(%#%);h)#M%( >%)%;#$!$!(<&$((!#)A-$=(!#)A0123f2i1:200hkihA 5AL"$#)^*V6Q%R#)>8V6.%$%(%L6%!(A*"%$=#!>(!&(4 =!%!$!(<&$#!)"$#?#%!$!(<&$((!#)A9$ *%!$RA012jfig:igkh1A 21A7#(;L6*)$=^W6L#??%$d6%!(A9(%=$#!)!#?=!(?!"4 ")>#;!$!(<&$((!#):$%M% #;%=$$%)%=)o% !)!M!)=%AR8$+&$((!#)A0123fj:2231A 22A]!)^M%(86X%%?%$)>L6-$Y)*R6L=#%)KA%9-W !!##(#%%$?)%!$!(<&$((!#)=#?"(%`A*%!$A 0123f211:21jjkg3A 20A'!%(L6*!$!!VA8$!($%?#%()>!)!$!(<&$((!#): $%=%)!M!)=%!)$!)(!#)!("%$"%=M%AR8?-#(( -!$#(A0123fmi:0iihk3hA 2iA8?!R6lY;;%(V6#)%+6l#%$]68((%%V6 U#$>%$VAL$=$!(=!)>%#;!$!(?#=!$? % #!)%!$!(<&$((!#))%>#!A -$=(!#)A 255jf5m:i2hjkmiA 23A'!%(L6W!=96L!M%(%M!P6%!(A9!$(?!)!>%?%)#; !$!(<&$((!#)#"$%M%)=!$#M!=(!$=#?"(=!#)A 9$*%!$RA0123fih:233gkhmA 2hA-!$#9P6d$%$;%(()%$*6W(#O%$.6X%>(%$dQA-()=!( =(!<=!#)#;!$!(<&$((!#)"##$($%p%=%?"#$!( "%$%)=%:)>;$#? 2625h"!%)=#))#( ?#)#$% ?"(!)!&(%%M=%AR8? -#((-!$#(A 0123fmi,0hd8@:0g31kgA 2mAU!$96V!%%)U6'%?!)+6.%$%(%L6L=#%)K6 V!%%)RWA8"$#"%=M%$!)#?O%=#)$#((%$!(#) %)=%)=%!)"$%=#$#;(!%4"!%"##"%$!M% !$!(<&$((!#)"#i1!!)%"$%M%)M%M!(%#; &!$!("!=)>A*%!$7?A0123f22:22hmkm0A.

(19)

Referenties

GERELATEERDE DOCUMENTEN

In alle andere gevallen: tel het aan- tal oneven hoekpunten, deel dit aantal door 2 en je hebt het aantal lijnen dat je aaneengesloten mini- maal moet hebben om de figuur

Ten slotte zijn onze jonge auditors van mening dat de toekomstige auditor meer samen moet spelen met andere disciplines, met andere wetenschappen en zich veel meer moet gaan

De dagen zijn veel langer, omdat het ‛s morgens vroeg licht is en ‛s avonds laat donker wordt.. In de natuur is alles groen en we brengen dit warme seizoen met een ijsje bij het

Bij City Line voordeuren maakt u zelf de keuze voor een van de drie serviceniveaus Plus, Pro of Premium.. Van zelf doen tot maatwerk of compleet door een

Il faudra les mémoriser. Quand on regarde cette liste de plus près, on constate que la plupart de ces verbes sont très souvent utilisés. Le fait de les connaître sera donc

Iris zegt dat de verbranding van het rubber waarschijnlijk niet volledig is geweest en dat de ontkleuring van de vloeistof in de erlenmeyer ook veroorzaakt kan zijn door

Waar de Genadestroom van het Kruisoffer van Christus wordt drooggelegd, door vervalsing van de Wijdingen en Heilig Misoffer, daar is het ware Katholieke Geloof niet meer

Zorg en aandacht voor elkaar, het beschikbaar zijn voor het bespreken van zingevingvragen en het aangesproken kunnen worden op geloofszaken vormen het hart van het pastorale werk..