B) Methoden
4) C ONCLUSIE
Cognitieve interventies hebben een duidelijk potentieel om de symptomatische progressie van AD te vertragen. De toegevoegde waarde tegenover medicatie in monotherapie is duidelijk, er bestaan vele beloftevolle onderzoeken en neurobiologische veranderingen werden vastgelegd via beeldvorming. Toch is aan deze interventies een inherente complexiteit verbonden. Zowel variabele aspecten van de interventies zelf als karakteristieken van de individuele PWA’s zorgen voor een bijzonder heterogene literatuur, met sterk variërende effectgroottes en
onduidelijkheden. Ook methodologische problemen, waaronder het gebruik van verschillende controlegroepen, het niet correct gebruiken van de bestaande terminologie, te kleine steekproefgroottes etc. zorgen ervoor dat de bewijskracht voor deze interventies belemmerd wordt. Meer onderzoek is dus nodig, waarbij de focus vooral zal moeten liggen in het ontwikkelen van gepersonaliseerde CR-interventies die rekening houden met het individu in zijn totaliteit en in combinatie met medicatie. Dergelijke holistische aanpak zou immers de meest effectieve zijn.
Referenties
1. World Health Organization. Dementia [Internet]. Genève: World Health Organization; 2015 Mrt [geraadpleegd 2016 april 2]. Beschikbaar via: http://www.who.int/mediacentre/factsheets/fs362/en/
2. Prince M, Wimo A, Guerchet M, Ali GC, Wu YT, Prina M. World Alzheimer Report 2015: The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends. Londen: Alzheimer’s Disease International; 2015.
3. Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers.
Biochem Pharmacol. 2014;88(4):640-51.
4. Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer's and vascular types.
Biomed Res Int. 2014;2014:908915.
5. 2015 Alzheimer's disease facts and figures. Alzheimers Dement. 2015;11(3):332-84.
6. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer's disease. Lancet.
2011;377(9770):1019-31.
7. Prince M, Albanese E, Guerchet M, Prina M. World Alzheimer Report 2014: Dementia and Risk Reduction: An analysis of protective and modifiable factors. Londen: Alzheimer’s Disease International; 2014.
8. Kabinet van Vlaams minister van Welzijn, Volksgezondheid en Gezin, Jo Vandeurzen. Naar een dementievriendelijk Vlaanderen: Dementieplan Vlaanderen 2010-2014. Brussel: Vlaamse Regering;
2011.
9. Ziekte van Alzheimer: Impact van de beperkingsmaatregelen op de terugbetaling van geneesmiddelen [Internet]. Brussel: Onafhankelijke Ziekenfondsen; 2013 [geraadpleegd 2015 juni 20]. Beschikbaar via:
http://www.mloz.be/files/alzheimernl_0.pdf
10. Jonker C, Slaets JPJ, Verhey FRJ. Handboek dementie: Laatste inzichten in diagnostiek en behandeling. Houten: Bohn Stafleu van Loghum; 2009.
11. Winslow BT, Onysko MK, Stob CM, Hazlewood KA. Treatment of Alzheimer disease. Am Fam Physician. 2011;83(12):1403-12.
12. Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer's disease: Past, present and future.
Neuropharmacology. 2014;76 Pt A:27-50.
13. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Jr., Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on
Aging-Alzheimer's Association workgroups on diagnostic guidelines for Aging-Alzheimer's disease. Alzheimers Dement. 2011;7(3):263-9.
14. Weintraub S, Wicklund AH, Salmon DP. The neuropsychological profile of Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(4):a006171.
15. Prince M, Bryce R, Ferri C. World Alzheimer Report 2011: The benefits of early diagnosis and intervention. Londen: Alzheimer’s Disease International; 2011.
16. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Alzheimers Dement. 2011;7(3):270-9.
17. Alzheimer’s Association. 10 Early Signs and Symptoms of Alzheimer’s [Internet]. Chicago:
Alzheimer’s Association; 2009 [geraadpleegd 2015 juni 20]. Beschikbaar via:
http://www.alz.org/alzheimers_disease_10_signs_of_alzheimers.asp
18. Borisovskaya A, Pascualy M, Borson S. Cognitive and neuropsychiatric impairments in Alzheimer's disease: current treatment strategies. Curr Psychiatry Rep. 2014;16(9):470.
19. Sheehan B. Assessment scales in dementia. Ther Adv Neurol Disord. 2012;5(6):349-58.
20. Hort J, O'Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, et al. EFNS guidelines for the diagnosis and management of Alzheimer's disease. Eur J Neurol. 2010;17(10):1236-48.
21. Alzheimer’s Disease Education and Referral (ADEAR) Center. Alzheimer's disease, unraveling the mystery. Bethesda (MD): National Institute on Aging (US); 2008 Sep. 43p. Publication No.: 08-3782 22. Health Quality Ontario. The appropriate use of neuroimaging in the diagnostic work-up of dementia: an
evidence-based analysis. Ont Health Technol Assess Ser. 2014;14(1):1-64.
23. Sulkama R. De ziekte van Alzheimer [Internet]. Leuven: Duodecim Medical Publications Ltd; 2010 Nov 25 [geraadpleegd 2016 maart 25]. Beschikbaar via:
https://www.ebmpracticenet.be/nl/Paginas/default.aspx?ebmid=ebm00756
24. Moll van Charante E, Perry M, Vernooij-Dassen MJFJ, Boswijk DFR, Stoffels J, Achthoven L, Luning-Koster MN. NHG-Standaard Dementie (derde herziening) [Internet]. Utrecht: Nederlands
Huisartsengenootschap; 2012 [geraadpleegd 2016 april 2]. Beschikbaar via:
https://www.nhg.org/standaarden/volledig/nhg-standaard-dementie
25. Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, et al. 2014 Update of the
Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.
Alzheimers Dement. 2015;11(6):e1-120.
26. Hulstaert F, Thiry N, Eyssen M, Vrijens F. Medicamenteuze en niet medicamenteuze interventies voor de ziekte van Alzheimer: een rapid assessment. Brussel: Federaal Kenniscentrum voor de
Gezondheidszorg; 2009. 118 p. Report No.: 111A
27. Alves J, Magalhaes R, Thomas RE, Goncalves OF, Petrosyan A, Sampaio A. Is there evidence for cognitive intervention in Alzheimer disease? A systematic review of efficacy, feasibility, and cost-effectiveness. Alzheimer Dis Assoc Disord. 2013;27(3):195-203.
28. Sitzer DI, Twamley EW, Jeste DV. Cognitive training in Alzheimer's disease: a meta-analysis of the literature. Acta Psychiatr Scand. 2006;114(2):75-90.
29. Herholz SC, Herholz RS, Herholz K. Non-pharmacological interventions and neuroplasticity in early stage Alzheimer's disease. Expert Rev Neurother. 2013;13(11):1235-45.
30. Droes RM, van der Roest HG, van Mierlo L, Meiland FJ. Memory problems in dementia: adaptation and coping strategies and psychosocial treatments. Expert Rev Neurother. 2011;11(12):1769-81; quiz 82.
31. Buschert V, Bokde AL, Hampel H. Cognitive intervention in Alzheimer disease. Nat Rev Neurol.
2010;6(9):508-17.
32. Ponds R, van Heugten C, Fasotti L, Wekking E. Neuropsychologische behandeling. R. Ponds, C. Van Heugten, L. Fasotti, E. Wekking. Amsterdam: Uitgeverij Boom; 2010.
33. Nardone R, Holler Y, Tezzon F, Christova M, Schwenker K, Golaszewski S, et al. Neurostimulation in Alzheimer's disease: from basic research to clinical applications. Neurol Sci. 2015;36(5):689-700.
34. Kroes M, Sjokvist GS, Allen F, Eyssen M, Paulus D. Dementie: welke niet-farmacologische interventies?. Brussel: Federaal Kenniscentrum voor de Gezondheidszorg; 2011. 142 p. Report No.:
160A
35. Belgisch Centrum voor Farmacotherapeutische Informatie. Transparantiefiche dementie [Internet].
Gent: Belgisch Centrum voor Farmacotherapeutische Informatie; 2008 [Laatste update 2014;
geraadpleegd 2016 maart 25]. Beschikbaar via: http://www.bcfi.be/PDF/TFT/TN_Dem.pdf
36. National Institute for Health and Care Excellence. Dementia: supporting people with dementia and their carers in health and social care [Internet]. Londen: National Institute for Health and Care Excellence;
2006 Nov [Laatste update 2015 Apr; geraadpleegd 2016 maart 25]. Beschikbaar via:
https://www.nice.org.uk/guidance/cg42
37. World Health Organization. mhGAP Intervention Guide for mental, neurological and substance use disorders in non-specialized health settings [Internet]. Genève: World Health Organization; 2011 [geraadpleegd 2016 maart 25]. Beschikbaar via:
http://apps.who.int/iris/bitstream/10665/44406/1/9789241548069_eng.pdf
38. Alzheimer’s Association. Management and Patient Care [Internet]. Chicago: Alzheimer’s Association;
[publicatiedatum onbekend] [geraadpleegd 2016 maart 25]. Beschikbaar via:
http://www.alz.org/health-care-professionals/medical-management-patient-care.asp
39. Parsons-Suhl K, Johnson ME, McCann JJ, Solberg S. Losing one's memory in early Alzheimer's disease. Qual Health Res. 2008;18(1):31-42.
40. Iavarone A, Ziello AR, Pastore F, Fasanaro AM, Poderico C. Caregiver burden and coping strategies in caregivers of patients with Alzheimer's disease. Neuropsychiatr Dis Treat. 2014;10:1407-13.
41. Brandon, T, Sonali, N.S, Cralen, D, Jose, A, Faison, W.E. Household Members of Persons with Alzheimer's Disease: Health Conditions, Healthcare Resource Use, and Healthcare Costs. J AM Geriatric Society. 2014;62(3): 435-441.
42. Bahar-Fuchs A, Clare L, Woods B. Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2013;6:CD003260.
43. Woods B, Aguirre E, Spector AE, Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev. 2012;2:CD005562.
44. Choi J, Twamley EW. Cognitive rehabilitation therapies for Alzheimer's disease: a review of methods to improve treatment engagement and self-efficacy. Neuropsychol Rev. 2013;23(1):48-62.
45. Bier N, Van Der Linden M, Gagnon L, Desrosiers J, Adam S, Louveaux S, et al. Face-name association learning in early Alzheimer's disease: a comparison of learning methods and their underlying
mechanisms. Neuropsychol Rehabil. 2008;18(3):343-71.
46. Noonan KA, Pryer LR, Jones RW, Burns AS, Lambon Ralph MA. A direct comparison of errorless and errorful therapy for object name relearning in Alzheimer's disease. Neuropsychol Rehabil.
2012;22(2):215-34.
47. Liberati G, Raffone A, Olivetti Belardinelli M. Cognitive reserve and its implications for rehabilitation and Alzheimer's disease. Cogn Process. 2012;13(1):1-12.
Geriatr Psychiatry Neurol. 2007;20(4):239-49.
49. Cherry KE, Hawley KS, Jackson EM, Boudreaux EO. Booster sessions enhance the long-term effectiveness of spaced retrieval in older adults with probable Alzheimer's disease. Behav Modif.
2009;33(3):295-313.
50. Lee SB, Park CS, Jeong JW, Choe JY, Hwang YJ, Park CA, et al. Effects of spaced retrieval training (SRT) on cognitive function in Alzheimer's disease (AD) patients. Arch Gerontol Geriatr.
2009;49(2):289-93.
51. Kinsella GJ, Ong B, Storey E, Wallace J, Hester R. Elaborated spaced-retrieval and prospective memory in mild Alzheimer's disease. Neuropsychol Rehabil. 2007;17(6):688-706.
52. Small JA. A new frontier in spaced retrieval memory training for persons with Alzheimer's disease.
Neuropsychol Rehabil. 2012;22(3):329-61.
53. Lalanne J, Gallarda T, Piolino P. "The Castle of Remembrance": New insights from a cognitive training programme for autobiographical memory in Alzheimer's disease. Neuropsychol Rehabil.
2015;25(2):254-82.
54. Carrillo MC, Dishman E, Plowman T. Everyday technologies for Alzheimer's disease care: Research findings, directions, and challenges. Alzheimers Dement. 2009;5(6):479-88.
55. Lancioni GE, La Martire ML, Singh NN, O'Reilly MF, Sigafoos J, Pinto K, et al. Persons with mild or moderate Alzheimer's disease managing daily activities via verbal instruction technology. Am J Alzheimers Dis Other Demen. 2008;23(6):552-62.
56. Kinsella GJ, Ong B, Storey E, Wallace J, Hester R. Elaborated spaced-retrieval and prospective memory in mild Alzheimer's disease. Neuropsychol Rehabil. 2007;17(6):688-706.
57. Hussey EP, Smolinsky JG, Piryatinsky I, Budson AE, Ally BA. Using mental imagery to improve memory in patients with Alzheimer disease: trouble generating or remembering the mind's eye?
Alzheimer Dis Assoc Disord. 2012;26(2):124-34.
58. Cherry KE, Simmons-D'Gerolamo SS. Long-term effectiveness of spaced-retrieval memory training for older adults with probable Alzheimer's disease. Exp Aging Res. 2005;31(3):261-89.
59. Bergamaschi S, Arcara G, Calza A, Villani D, Orgeta V, Mondini S. One-year repeated cycles of cognitive training (CT) for Alzheimer's disease. Aging Clin Exp Res. 2013;25(4):421-6.
60. Cipriani G, Bianchetti A, Trabucchi M. Outcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment.
Arch Gerontol Geriatr. 2006;43(3):327-35.
61. Herrera C, Chambon C, Michel BF, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia. 2012;50(8):1871-81.
62. Spironelli C, Bergamaschi S, Mondini S, Villani D, Angrilli A. Functional plasticity in Alzheimer's disease: effect of cognitive training on language-related ERP components. Neuropsychologia.
2013;51(8):1638-48.
63. Olazaran J, Reisberg B, Clare L, Cruz I, Pena-Casanova J, Del Ser T, et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord.
2010;30(2):161-78.
64. Jelcic N, Cagnin A, Meneghello F, Turolla A, Ermani M, Dam M. Effects of lexical-semantic treatment on memory in early Alzheimer disease: an observer-blinded randomized controlled trial. Neurorehabil Neural Repair. 2012;26(8):949-56.
65. Hwang HR, Choi SH, Yoon DH, Yoon BN, Suh YJ, Lee D, et al. The effect of cognitive training in patients with mild cognitive impairment and early Alzheimer's disease: a preliminary study. J Clin Neurol. 2012;8(3):190-7.
66. Huntley J, Bor D, Hampshire A, Owen A, Howard R. Working memory task performance and chunking in early Alzheimer's disease. Br J Psychiatry. 2011;198(5):398-403.
67. Kanaan SF, McDowd JM, Colgrove Y, Burns JM, Gajewski B, Pohl PS. Feasibility and efficacy of intensive cognitive training in early-stage Alzheimer's disease. Am J Alzheimers Dis Other Demen.
2014;29(2):150-8.
68. Law LL, Barnett F, Yau MK, Gray MA. Effects of functional tasks exercise on older adults with cognitive impairment at risk of Alzheimer's disease: a randomised controlled trial. Age Ageing.
2014;43(6):813-20.
69. Jelcic N, Agostini M, Meneghello F, Busse C, Parise S, Galano A, et al. Feasibility and efficacy of cognitive telerehabilitation in early Alzheimer's disease: a pilot study. Clin Interv Aging. 2014;9:1605-11.
70. Letts L, Minezes J, Edwards M, Berenyi J, Moros K, O'Neill C, et al. Effectiveness of interventions designed to modify and maintain perceptual abilities in people with Alzheimer's disease and related dementias. Am J Occup Ther. 2011;65(5):505-13.
71. Kawashima R. Mental exercises for cognitive function: clinical evidence. J Prev Med Public Health.
2013;46 Suppl 1:S22-7.
72. van Os Y, de Vugt ME, van Boxtel M. Cognitive Interventions in Older Persons: Do They Change the Functioning of the Brain? Biomed Res Int. 2015;2015:438908.
73. Felsenstein KM, Candelario KM, Steindler DA, Borchelt DR. Regenerative medicine in Alzheimer's disease. Transl Res. 2014;163(4):432-8.
74. Lee GY, Yip CC, Yu EC, Man DW. Evaluation of a computer-assisted errorless learning-based memory training program for patients with early Alzheimer's disease in Hong Kong: a pilot study. Clin Interv Aging. 2013;8:623-33.
75. Garcia-Alberca JM. Cognitive intervention therapy as treatment for behaviour disorders in Alzheimer disease: evidence on efficacy and neurobiological correlations. Neurologia. 2015;30(1):8-15.
76. Gaitan A, Garolera M, Cerulla N, Chico G, Rodriguez-Querol M, Canela-Soler J. Efficacy of an adjunctive computer-based cognitive training program in amnestic mild cognitive impairment and Alzheimer's disease: a single-blind, randomized clinical trial. Int J Geriatr Psychiatry. 2013;28(1):91-9.
77. Farina E, Mantovani F, Fioravanti R, Pignatti R, Chiavari L, Imbornone E, et al. Evaluating two group programmes of cognitive training in mild-to-moderate AD: is there any difference between a 'global' stimulation and a 'cognitive-specific' one? Aging Ment Health. 2006;10(3):211-8.
78. Lancioni G, Singh N, O'Reilly M, Zonno N, Cassano G, De Vanna F, et al. Persons with Alzheimer's disease perform daily activities using verbal-instruction technology: a maintenance assessment. Dev Neurorehabil. 2010;13(2):103-13.
79. Treiber KA, Carlson MC, Corcoran C, Norton MC, Breitner JC, Piercy KW, et al. Cognitive stimulation and cognitive and functional decline in Alzheimer's disease: the cache county dementia progression study. J Gerontol B Psychol Sci Soc Sci. 2011;66(4):416-25.
80. Spector A, Woods B, Orrell M. Cognitive stimulation for the treatment of Alzheimer's disease. Expert Rev Neurother. 2008;8(5):751-7.
81. Ozdemir L, Akdemir N. Effects of multisensory stimulation on cognition, depression and anxiety levels of mildly-affected Alzheimer's patients. J Neurol Sci. 2009;283(1-2):211-3.
82. Yu F, Kolanowski AM, Strumpf NE, Eslinger PJ. Improving cognition and function through exercise intervention in Alzheimer's disease. J Nurs Scholarsh. 2006;38(4):358-65.
83. Wollen KA. Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Altern Med Rev. 2010;15(3):223-44.
84. Swall A, Ebbeskog B, Lundh Hagelin C, Fagerberg I. Can therapy dogs evoke awareness of one's past and present life in persons with Alzheimer's disease? Int J Older People Nurs. 2015;10(2):84-93.
85. Duff MC, Gallegos DR, Cohen NJ, Tranel D. Learning in Alzheimer's disease is facilitated by social interaction. J Comp Neurol. 2013;521(18):4356-69.
86. Jimbo D, Kimura Y, Taniguchi M, Inoue M, Urakami K. Effect of aromatherapy on patients with Alzheimer's disease. Psychogeriatrics. 2009;9(4):173-9.
87. Ward-Smith P, Llanque SM, Curran D. The effect of multisensory stimulation on persons residing in an extended care facility. Am J Alzheimers Dis Other Demen. 2009;24(6):450-5.
88. Arroyo-Anllo EM, Diaz JP, Gil R. Familiar music as an enhancer of self-consciousness in patients with Alzheimer's disease. Biomed Res Int. 2013;2013:752965.
89. McGonigal-Kenny ML, Schutte DL. Nonpharmacologic management of agitated behaviors in persons with Alzheimer disease and other chronic dementing conditions. J Gerontol Nurs. 2006;32(2):9-14.
90. Samson S, Dellacherie D, Platel H. Emotional power of music in patients with memory disorders:
clinical implications of cognitive neuroscience. Ann N Y Acad Sci. 2009;1169:245-55.
91. Ziv N, Granot A, Hai S, Dassa A, Haimov I. The effect of background stimulative music on behavior in Alzheimer's patients. J Music Ther. 2007;44(4):329-43.
92. Venturelli M, Scarsini R, Schena F. Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am J Alzheimers Dis Other Demen. 2011;26(5):381-8.
93. Yu F, Kolanowski AM, Strumpf NE, Eslinger PJ. Improving cognition and function through exercise intervention in Alzheimer's disease. J Nurs Scholarsh. 2006;38(4):358-65.
94. Yu F, Thomas W, Nelson NW, Bronas UG, Dysken M, Wyman JF. Impact of 6-month aerobic exercise on Alzheimer's symptoms. J Appl Gerontol. 2015;34(4):484-500.
95. Arcoverde C, Deslandes A, Moraes H, Almeida C, Araujo NB, Vasques PE, et al. Treadmill training as an augmentation treatment for Alzheimer's disease: a pilot randomized controlled study. Arq
Neuropsiquiatr. 2014;72(3):190-6.
96. Lautenschlager NT, Cox K, Kurz AF. Physical activity and mild cognitive impairment and Alzheimer's disease. Curr Neurol Neurosci Rep. 2010;10(5):352-8.
97. Arcoverde C, Deslandes A, Rangel A, Rangel A, Pavao R, Nigri F, et al. Role of physical activity on the
Neuropsiquiatr. 2008;66(2B):323-7.
98. Eggermont L, Swaab D, Luiten P, Scherder E. Exercise, cognition and Alzheimer's disease: more is not necessarily better. Neurosci Biobehav Rev. 2006;30(4):562-75.
99. Perez CA, Cancela Carral JM. Benefits of physical exercise for older adults with Alzheimer's disease.
Geriatr Nurs. 2008;29(6):384-91.
100. Kramer AF, Erickson KI. Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. Trends Cogn Sci. 2007;11(8):342-8.
101. Yaguez L, Shaw KN, Morris R, Matthews D. The effects on cognitive functions of a movement-based intervention in patients with Alzheimer's type dementia: a pilot study. Int J Geriatr Psychiatry.
2011;26(2):173-81.
102. Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol. 2010;67(1):71-9.
103. Farina N, Tabet N, Rusted J. Habitual physical activity (HPA) as a factor in sustained executive function in Alzheimer-type dementia: a cohort study. Arch Gerontol Geriatr. 2014;59(1):91-7.
104. Tanigawa T, Takechi H, Arai H, Yamada M, Nishiguchi S, Aoyama T. Effect of physical activity on memory function in older adults with mild Alzheimer's disease and mild cognitive impairment. Geriatr Gerontol Int. 2014;14(4):758-62.
105. Canonici AP, Andrade LP, Gobbi S, Santos-Galduroz RF, Gobbi LT, Stella F. Functional dependence and caregiver burden in Alzheimer's disease: a controlled trial on the benefits of motor intervention.
Psychogeriatrics. 2012;12(3):186-92.
106. de Andrade LP, Gobbi LT, Coelho FG, Christofoletti G, Costa JL, Stella F. Benefits of multimodal exercise intervention for postural control and frontal cognitive functions in individuals with Alzheimer's disease: a controlled trial. J Am Geriatr Soc. 2013;61(11):1919-26.
107. Coelho FG, Andrade LP, Pedroso RV, Santos-Galduroz RF, Gobbi S, Costa JL, et al. Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer's disease: a controlled trial. Geriatr Gerontol Int. 2013;13(1):198-203.
108. La Rue A, Felten K, Duschene K, MacFarlane D, Price S, Zimmerman S, et al. Language-enriched exercise plus socialization for older adults with dementia: translation to rural communities. Semin Speech Lang. 2013;34(3):170-84.
109. Niu YX, Tan JP, Guan JQ, Zhang ZQ, Wang LN. Cognitive stimulation therapy in the treatment of neuropsychiatric symptoms in Alzheimer's disease: a randomized controlled trial. Clin Rehabil.
2010;24(12):1102-11.
110. Buettner LL, Fitzsimmons S, Atav S, Sink K. Cognitive stimulation for apathy in probable early-stage Alzheimer's. J Aging Res. 2011;2011:480890.
111. Hattori H, Hattori C, Hokao C, Mizushima K, Mase T. Controlled study on the cognitive and
psychological effect of coloring and drawing in mild Alzheimer's disease patients. Geriatr Gerontol Int.
2011;11(4):431-7.
112. Mossello E, Ridolfi A, Mello AM, Lorenzini G, Mugnai F, Piccini C, et al. Animal-assisted activity and emotional status of patients with Alzheimer's disease in day care. Int Psychogeriatr. 2011;23(6):899-905.
113. Sharer J. Tackling sundowning in a patient with Alzheimer's disease. Medsurg Nurs. 2008;17(1):27-9.
114. Staedtler AV, Nunez D. Nonpharmacological therapy for the management of neuropsychiatric symptoms of Alzheimer's disease: linking evidence to practice. Worldviews Evid Based Nurs.
2015;12(2):108-15.
115. Herrmann N, Gauthier S. Diagnosis and treatment of dementia: 6. Management of severe Alzheimer disease. CMAJ. 2008;179(12):1279-87.
116. Archer T. Physical exercise alleviates debilities of normal aging and Alzheimer's disease. Acta Neurol Scand. 2011;123(4):221-38.
117. Stella F, Canonici AP, Gobbi S, Galduroz RF, Cacao Jde C, Gobbi LT. Attenuation of neuropsychiatric symptoms and caregiver burden in Alzheimer's disease by motor intervention: a controlled trial. Clinics (Sao Paulo). 2011;66(8):1353-60.
118. Logsdon RG, McCurry SM, Teri L. A home health care approach to exercise for persons with Alzheimer's disease. Care Manag J. 2005;6(2):90-7.
119. Yu F, Swartwood RM. Feasibility and perception of the impact from aerobic exercise in older adults with Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2012;27(6):397-405.
120. Nascimento CM, Teixeira CV, Gobbi LT, Gobbi S, Stella F. A controlled clinical trial on the effects of exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer's disease.
Rev Bras Fisioter. 2012;16(3):197-204.
121. Rolland Y, Pillard F, Klapouszczak A, Reynish E, Thomas D, Andrieu S, et al. Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am Geriatr
Soc. 2007;55(2):158-65.
122. Clare L. Cognitive rehabilitation and people with dementia [Internet]. New York: Center for International Rehabilitation Research Information and Exchange; 2010 [geraadpleegd 2016 april 2].
Beschikbaar via: http://cirrie.buffalo.edu/encyclopedia/en/article/129/
123. Clare L, Linden DE, Woods RT, Whitaker R, Evans SJ, Parkinson CH, et al. Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am J Geriatr Psychiatry. 2010;18(10):928-39.
124. Thivierge S, Jean L, Simard M. A randomized cross-over controlled study on cognitive rehabilitation of instrumental activities of daily living in Alzheimer disease. Am J Geriatr Psychiatry. 2014;22(11):1188-99.
125. Kurz A, Thone-Otto A, Cramer B, Egert S, Frolich L, Gertz HJ, et al. CORDIAL: cognitive
rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial. Alzheimer Dis Assoc Disord. 2012;26(3):246-53.
126. Carbone G, Barreca F, Mancini G, Pauletti G, Salvi V, Vanacore N, et al. A home assistance model for dementia: outcome in patients with mild-to-moderate Alzheimer's disease after three months. Ann Ist Super Sanita. 2013;49(1):34-41.
127. Bharwani G, Parikh PJ, Lawhorne LW, VanVlymen E, Bharwani M. Individualized behavior management program for Alzheimer's/dementia residents using behavior-based ergonomic therapies.
Am J Alzheimers Dis Other Demen. 2012;27(3):188-95.
128. Viola LF, Nunes PV, Yassuda MS, Aprahamian I, Santos FS, Santos GD, et al. Effects of a
multidisciplinary cognitive rehabilitation program for patients with mild Alzheimer's disease. Clinics (Sao Paulo). 2011;66(8):1395-400.
129. Maci T, Pira FL, Quattrocchi G, Nuovo SD, Perciavalle V, Zappia M. Physical and cognitive
129. Maci T, Pira FL, Quattrocchi G, Nuovo SD, Perciavalle V, Zappia M. Physical and cognitive