ABC transporters and scavenger receptor BI : important mediators of lipid metabolism and atherosclerosis
Meurs, I.
Citation
Meurs, I. (2011, June 7). ABC transporters and scavenger receptor BI : important mediators of lipid metabolism and atherosclerosis. Retrieved from https://hdl.handle.net/1887/17686
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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ABC Transporters and Scavenger Receptor BI:
Important Mediators of Lipid Metabolism and Atherosclerosis
Illiana Meurs
ABC Transporters and Scavenger Receptor BI:
Important Mediators of Lipid Metabolism and Atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 7 juni 2011 klokke 15.00 uur
door
Illiana Meurs geboren te ‘s-Gravenhage
in 1981
Promotiecommissie
Promotor: Prof. Dr. Th.J.C. van Berkel Co-promotor: Dr. M. van Eck
Overige leden: Prof. Dr. M. Danhof (LACDR)
Prof. Dr. A. K. Groen (University of Groningen) Prof. Dr. L. M. Havekes (LUMC)
Dr. R. Masereeuw (University of Nijmegen)
The studies presented in this thesis were supported by grant 917.66.301 from the Netherlands Organization for Scientific Research (NWO) and were performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
Financial support for the printing of this thesis was provided by:
- LACDR
- Leiden University
- Chiron Development Consultancy
Aan mijn ouders en opa
Cover design: Robin Alderliesten & Illiana Meurs
Bone marrow-derived macrophages loaded with βVLDL Printing: Wöhrmann Print Service
ISBN: 978-90-8570-757-8 Meurs, Illiana
ABC Transporters and Scavenger Receptor BI: Important Mediators of Lipid Metabolism and Atherosclerosis
Proefschrift Leiden
Met literatuur opgave - Met samenvatting in het Nederlands
© 2011 I Meurs
No parts of this thesis may be reproduced or transmitted in any form or by any means, without permission of the author.
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Table of contents
Chapter 1:
1.1 1.2
1.3
1.4 Chapter 2:
Chapter 3:
Chapter 4:
Chapter 5:
Chapter 6:
Chapter 7:
Chapter 8:
General introduction Atherosclerosis
HDL: key molecule in cholesterol efflux and the prevention of atherosclerosis
Curr Pharm Design. 2010, 16:1445-1467
Role of the ABC transporters ABCA1 and ABCG1 in foam cell formation and atherosclerosis
Future Lipidol. 2008, 3:675-687 Outline of the thesis
The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis
Submitted for publication
Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDL receptor knockout mice
Biochem Biophys Res Commun. 2010, 395:387-394
Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
Submitted for publication
Macrophage ABCB1 deficiency increases serum cholesterol levels but does not promote atherosclerosis in LDLr knockout mice on Western-type diet
Submitted for publication
Transcriptional profiling of ABC transporters in murine foam cells and atherosclerotic lesions identifies putative novel targets for improving macrophage lipid homeostasis
Identification of novel macrophage cholesterol-responsive genes in peritoneal and bone marrow-derived macrophage foam cells
HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes
Exp Hematol. 2005, 33:1309-1319
Page 227
253
285
299 306 309 312 Chapter 9:
Chapter 10:
Chapter 11:
Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol
Atheroscler Thromb Vasc Biol. 2011, 31:34-42
Genetic variant of the scavenger receptor BI in humans N Engl J Med. 2011, 364:136-45
General discussion and perspectives Nederlandse samenvatting
List of abbreviations List of publications Curriculum Vitae
