ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis
Ye, D.
Citation
Ye, D. (2008, November 4). ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis. Retrieved from https://hdl.handle.net/1887/13220
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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ABC-transporters and Lipid Transfer Proteins:
Important Players in Macrophage Cholesterol Homeostasis and Atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 4 november 2008 klokke 11:15 uur
door
Dan Ye
geboren te Jiande, China in 1979
PROMOTIECOMMISSIE
Promotor: Prof. dr. Th.J.C. van Berkel Co-promotor: Dr. M. van Eck
Referent: Prof. dr. M.H. Hofker (University of Groningen) Overige leden: Prof. dr. M. Danhof
Prof. dr. C.J.M. de Vries (University of Amsterdam) Dr. M. Jauhiainen (Biomedicum, Helsinki, Finland) Dr. P.C.N. Rensen
The studies described in this thesis were performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.
The thesis was financially supported by the Chinese Scholarship Council.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was also financially supported by:
- LACDR - Pfizer B.V.
- AstraZeneca
做最好的自己。
/ To be your personal best.
- K aifu L ee -
For my parents and my husband Jianhua N i
Printing: WÖhrmann Print Service, The Netherlands
ISBN: 978-90-74538-68-8
Ye, Dan
ABC-transporters and lipid transfer proteins: important players in macrophage cholesterol homeostasis and atherosclerosis
Proefschrift Leiden - Met lit. opg - Met samenvatting in het Nederlands
© 2008 Dan Ye
No part of this thesis may be reproduced or transmitted in any form or by any means, without written permission from the author.
TABLE OF CONTENTS
Chapter 1 General introduction 7
Chapter 2 Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice
33
Chapter 3 Macrophage ATP-binding cassette transporter A1 over-expression inhibits atherosclerotic lesion progression in LDL receptor knockout mice
47
Chapter 4 Overexpressing macrophage ABCA1 by bone marrow transplantation does not induce the regression of established atherosclerosis in LDL receptor knockout mice
59
Chapter 5 Macrophage ATP-binding cassette transporter A5 controls susceptibility to atherosclerosis in LDL receptor knockout mice
77
Chapter 6 Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development
93
Chapter 7 Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development inLDL receptor knockout mice
109
Chapter 8 Reduced leukocyte cholesteryl ester transfer protein expression in acute coronary syndromes
125
Chapter 9 Cholesteryl ester transfer protein modulates LPS- induced TNF-α production and forms a host defense mechanism against systemic inflammation
143
Chapter 10 Summaries and perspectives 10.1 English summary
10.2 Nederlandse samenvatting 10.3中文综述
159 159 166 177
List of abbreviations 181
List of publications 183
Curriculum vitae 185
