Cholesterol and phospholipid transporters in atherosclerotic lesion development
Pennings, M.
Citation
Pennings, M. (2008, September 16). Cholesterol and phospholipid transporters in
atherosclerotic lesion development. Division of Biopharmaceutics of the Leiden/Amsterdam Center for Drug Research|Leiden University Medical Center (LUMC), Leiden University.
Retrieved from https://hdl.handle.net/1887/13099
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Cholesterol and Phospholipid Transporters in Atherosclerotic Lesion Development
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op 16 september 2008
klokke 13:45 uur
door
Marieke Pennings geboren te Zaanstad
in 1976
Promotiecommissie
Promotor : Prof. Dr. Th.J.C. Van Berkel
Co-promotor : Dr. M. Van Eck
Referent : Prof. Dr. Ir. L.M. Havekes
Overige leden : Prof. Dr. M. Danhof
Dr. A.K. Groen (UvA) Prof. Dr. E.R. de Kloet Prof. Dr. F. Kuipers (RUG)
The study described in this thesis was financially supported by a ZonMw grant (192-02-063) and was performed at the Division of Biopharmaceutics of the Leiden Amsterdam Center for Drug Research, the Netherlands.
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Contents
Chapter 1 Introduction 7
Chapter 2 Regulation of cholesterol homeostasis in macrophages 19 and consequences for atherosclerotic lesion development
Chapter 3 Bone marrow derived multidrug resistance protein ABCB4 39 protects against atherosclerotic lesion development in LDL
receptor knock out mice
Chapter 4 Scavenger receptor BI and ATP-binding cassette transporter A1 59 in reverse cholesterol transport and atherosclerosis
Chapter 5 ABCA1/SR-BI double deficient mice demonstrate the 79 independent roles for ABCA1 and SR-BI in reverse
cholesterol transport
Chapter 6 Massive foam cell formation, atherosclerotic lesion development, 95 and inflammation by combined deletion of ABCA1 and SR-BI in
bone marrow-derived cells in LDL receptor knockout mice
Chapter 7 Summary and concluding remarks 119
Nederlandse Samenvatting 125
Abbreviations 133
Publications 135
Curriculum Vitae 137
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