Cholesterol and phospholipid transporters in atherosclerotic lesion development

To study the role of macrophage ABCA1 and SR-BI in atherosclerotic lesion development in absence of effects on HDL cholesterol levels, bone marrow transplantation studies

However, for long the role of the macrophage LDL receptor in foam cell formation and atherosclerotic lesion development was thought to be limited, as it is rapidly downregulated

In vitro foam cell formation, induced with acetylated LDL (AcLDL) in peritoneal macrophages, was increased in the absence of ABCB4, possibly due to a 2-fold (p<0.05)

Abstract Scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) are expressed both in macrophages and in the liver, implicating an important

VLDL secretion in wild type (WT, open squares), SR-BI deficient (SR-BI KO open triangles), ABCA1 deficient (ABCA1 KO, open circles) and ABCA1/SR-BI double deficient (dKO, closed

In conclusion, despite lower serum cholesterol levels, combined deletion of ABCA1 and SR-BI in bone marrow-derived cells induces massive foam cell formation, inflammation,

Systemic disruption of ABCB4 in mice results in a virtual absence of phospholipids in bile and a strongly impaired biliary cholesterol secretion, indicating that ABCB4 plays

Omdat ABC-transporters de asymmetrie van celmembranen kunnen beïnvloeden door fosfolipiden van de binnenkant naar de buitenkant te transporteren, hebben wij de hypothese