University of Groningen
Unravelling the molecular mechanisms underlying mitochondrial dysfunction in metabolic
diseases
Mposhi, Archibold
DOI:10.33612/diss.146092791
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Publication date: 2020
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Mposhi, A. (2020). Unravelling the molecular mechanisms underlying mitochondrial dysfunction in metabolic diseases. University of Groningen. https://doi.org/10.33612/diss.146092791
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Unravelling the molecular mechanisms underlying
mitochondrial dysfunction in metabolic diseases
The studies described in this thesis were financially supported by:
University of Groningen, Graduate School of Medical Sciences Jan Kornelis de Cock Foundation
Printing of this thesis was financially supported by:
University of Groningen
University Medical Centre Groningen Graduate School of Medical Sciences
Layout and cover design: Archibold Mposhi
Printed by: Proefschrift All In One (AIO)
Copyright © 2020 by Archibold Mposhi
All rights reserved. No Part of this publication may be reproduced or transmitted in any form or by any means without prior permission of the author, or, when appropriate, of the publisher of the publications
Unravelling the molecular
mechanisms underlying
mitochondrial dysfunction in
metabolic diseases
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Thursday 3 December 2020 at 9.00 hours
by
Archibold Mposhi
born on 22 May 1988 in Marondera, Zimbabwe
The studies described in this thesis were financially supported by:
University of Groningen, Graduate School of Medical Sciences Jan Kornelis de Cock Foundation
Printing of this thesis was financially supported by:
University of Groningen
University Medical Centre Groningen Graduate School of Medical Sciences
Layout and cover design: Archibold Mposhi
Printed by: Proefschrift All In One (AIO)
Copyright © 2020 by Archibold Mposhi
All rights reserved. No Part of this publication may be reproduced or transmitted in any form or by any means without prior permission of the author, or, when appropriate, of the publisher of the publications
Unravelling the molecular
mechanisms underlying
mitochondrial dysfunction in
metabolic diseases
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Thursday 3 December 2020 at 9.00 hours
by
Archibold Mposhi
born on 22 May 1988 in Marondera, Zimbabwe
Promoters
Prof. dr. K.N. Faber Prof. dr. M.G. Rots
Assessment Committee
Prof. dr. W.K. vander Berghe Prof. dr. B.M. Bakker
Prof. dr. A.J. Moshage
Paranymphs
Ruxandra A. Nagy Fabio Aguilar-Mora
Promoters
Prof. dr. K.N. Faber Prof. dr. M.G. Rots
Assessment Committee
Prof. dr. W.K. vander Berghe Prof. dr. B.M. Bakker
Prof. dr. A.J. Moshage
Paranymphs
Ruxandra A. Nagy Fabio Aguilar-Mora
Table of contents
Chapter 1: General Introduction 1 - 20
Chapter 2: Regulation of mitochondrial gene expression, the epigenetic enigma
Archibold Mposhi, Monique G.P van der Wijst, Klaas Nico Faber and Marianne G. Rots. Frontiers in Bioscience.
2017;22:1099-1113.
21 - 50
Chapter 3: A role of mitochondrial DNA methylation in mitochondrial
dysfunction in NAFLD
Archibold Mposhi, Janette Heegsma, Vincent E. de Meijer, Bart (A.J.A.) van de Sluis, Svenja Sydor, Lars P. Bechmann, Ikbal Agah Ince, Klaas Nico Faber and Marianne G. Rots.
51 - 98
Chapter 4: Increased mtDNA methylation correlates with decreased
ATP generating capacity in myopathy patients: Unexplained myopathies explained?
Archibold Mposhi, Dilemin Yildiz, Crista Kampert, Kevin P. Mennega, Tom J. de Koning, Klaas Nico Faber, Marcel Ruiters, Klary E. Niezen-Koning and Marianne G. Rots.
99 - 132
Chapter 5: Carbon monoxide directly promotes primary hepatocyte
proliferation in vitro involving the mTOR pathway
Archibold Mposhi, Tjasso Blokzijl, Marianne G. Rots and Klaas Nico Faber.
133 - 164
Chapter 6: CORM3 suppresses inflammatory signalling in
lipid-loaded hepatocytes.
Archibold Mposhi, Ali Saeed, Janette Heegsma, Marianne G. Rotsand Klaas Nico Faber.
165 - 192
Chapter 7: Summary and General Discussion 193 - 212 Appendices: Nederlandse Samenvatting, Acknowledgements
Biography, List of publications, Shadows in the light
Table of contents
Chapter 1: General Introduction 1 - 20
Chapter 2: Regulation of mitochondrial gene expression, the epigenetic enigma
Archibold Mposhi, Monique G.P van der Wijst, Klaas Nico Faber and Marianne G. Rots. Frontiers in Bioscience.
2017;22:1099-1113.
21 - 50
Chapter 3: A role of mitochondrial DNA methylation in mitochondrial
dysfunction in NAFLD
Archibold Mposhi, Janette Heegsma, Vincent E. de Meijer, Bart (A.J.A.) van de Sluis, Svenja Sydor, Lars P. Bechmann, Ikbal Agah Ince, Klaas Nico Faber and Marianne G. Rots.
51 - 98
Chapter 4: Increased mtDNA methylation correlates with decreased
ATP generating capacity in myopathy patients: Unexplained myopathies explained?
Archibold Mposhi, Dilemin Yildiz, Crista Kampert, Kevin P. Mennega, Tom J. de Koning, Klaas Nico Faber, Marcel Ruiters, Klary E. Niezen-Koning and Marianne G. Rots.
99 - 132
Chapter 5: Carbon monoxide directly promotes primary hepatocyte
proliferation in vitro involving the mTOR pathway
Archibold Mposhi, Tjasso Blokzijl, Marianne G. Rots and Klaas Nico Faber.
133 - 164
Chapter 6: CORM3 suppresses inflammatory signalling in
lipid-loaded hepatocytes.
Archibold Mposhi, Ali Saeed, Janette Heegsma, Marianne G. Rotsand Klaas Nico Faber.
165 - 192
Chapter 7: Summary and General Discussion 193 - 212 Appendices: Nederlandse Samenvatting, Acknowledgements
Biography, List of publications, Shadows in the light
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