University of Groningen
Exploring cellular and molecular mechanisms underlying endothelial heterogeneity in sepsis
Dayang, Erna
DOI:
10.33612/diss.160307653
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Dayang, E. (2021). Exploring cellular and molecular mechanisms underlying endothelial heterogeneity in sepsis. University of Groningen. https://doi.org/10.33612/diss.160307653
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Stellingen behorende bij het proefschrift
Exploring cellular and molecular mechanisms underlying endothelial heterogeneity in sepsis
1. The pathophysiology of sepsis-associated organ dysfunction differs per organ, which is partly attributed to variation in cellular and molecular involvement of endothelial cells in organs (Chapter 2 and 3; this thesis).
2. Cecal ligation and puncture is a murine polymicrobial sepsis model that causes distinct spatial and temporal patterns of neutrophil infiltration in the microvascular beds of the lung and kidney (Chapter 3; this thesis).
3. In murine experimental sepsis, endothelial cells actively respond by expressing adhesion molecules E-selectin and VCAM-1 in an organ-, (micro)vascular bed-, and cell-specific manner (Chapter 3 and 4; this thesis).
4. Exposure of endothelial cells to lipopolysaccharide in vitro leads to the formation of four distinct cell subpopulations based on E-selectin and VCAM-1 expression, each characterized by different inflammatory gene profiles (Chapter 4 and 5; this thesis).
5. In endothelial cells in vitro, the disparate engagement of Toll-like receptor 4 (TLR4) and retinoic inducible gene-I (RIG-I) receptors in response to lipopolysaccharide underlie the formation of endothelial subpopulations that each express a specific repertoire of inflammatory genes (Chapter 4; this thesis).
6. Focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) are important signal transduction molecules that can be pharmacologically targeted to attenuate lipopolysaccharide-induced endothelial inflammatory activation (Chapter 6; this thesis).
7. You might not be able to control every situation and its outcome, but you can control your attitude and how you deal with it.
8. In every job that must be done There is an element of fun You find the fun and- SNAP! The job's a game. (Mary Poppins)
