University of Groningen
Exploring cellular and molecular mechanisms underlying endothelial heterogeneity in sepsis
Dayang, Erna
DOI:
10.33612/diss.160307653
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Publication date:
2021
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Citation for published version (APA):
Dayang, E. (2021). Exploring cellular and molecular mechanisms underlying endothelial heterogeneity in
sepsis. University of Groningen. https://doi.org/10.33612/diss.160307653
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Exploring cellular and molecular
mechanisms underlying
endothelial heterogeneity in
sepsis
Dayang Erna Zulaikha
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Copyright© Dayang Erna Zulaikha, 2021
All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without permission of the author.
Printing of this dissertation was kindly supported by:
Front cover design: Muzamir Rahman & Khalisa Sulaiman (artwork) Lay-out: Dayang Erna Zulaikha & Nafiseh Ghazanfari
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Exploring cellular and molecular
mechanisms underlying endothelial
heterogeneity in sepsis
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 24 March 2021 at 14.30 hours
by
Dayang Erna Zulaikha
born on 7 July 1986 in Sarawak, Malaysia554817-L-sub01-bw-Erna 554817-L-sub01-bw-Erna 554817-L-sub01-bw-Erna 554817-L-sub01-bw-Erna Processed on: 15-2-2021 Processed on: 15-2-2021 Processed on: 15-2-2021
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Supervisor Prof. G. Molema Co-supervisors Dr. J. Moser Dr. M. van Meurs Assessment committee Prof. S.P. Berger Prof. J. van Buul Prof. P. Kümpers
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Paranymphs
M. Luxen T. Kuiper
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TABLE OF CONTENTS
CHAPTER 1
Introduction and Aim of the Thesis
CHAPTER 2
Review: Why do organs fail differently in sepsis? Endothelial heterogeneity and organ-specific failure phenotypes in sepsis
Manuscript in preparation
CHAPTER 3
Organ- and microvascular bed-specific endothelial responses and leukocyte infiltration in mice with abdominal sepsis
Work in progress
CHAPTER 4
Identification of Lipopolysaccharide-activated endothelial subpopulations with distinct inflammatory phenotypes and regulatory signaling mechanisms
Frontiers in Immunology (2019), 10: 1169
CHAPTER 5
Characterization of the heterogeneous response of endothelial subpopulations to Lipopolysaccharide by gene expression profiling
Work in progress
CHAPTER 6
Pharmacological inhibition of Focal adhesion kinase 1 (FAK1) and Anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates Lipopolysaccharide-induced endothelial inflammatory activation
Biomedicine & Pharmacotherapy (2021), 133: 111073
9 25 51 81 113 129
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CHAPTER 7
Summary, conclusions, and future perspectives
APPENDICES
Nederlandse samenvatting Acknowledgements About the author
165
