University of Groningen Exploring mechanisms of and therapeutic interventions for microvascular endothelial activation in shock Yan, Rui

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University of Groningen

Exploring mechanisms of and therapeutic interventions for microvascular endothelial

activation in shock

Yan, Rui

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Publication date: 2019

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Yan, R. (2019). Exploring mechanisms of and therapeutic interventions for microvascular endothelial activation in shock. University of Groningen.

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527121-L-sub01-bw-Yan 527121-L-sub01-bw-Yan 527121-L-sub01-bw-Yan 527121-L-sub01-bw-Yan Processed on: 11-12-2018 Processed on: 11-12-2018 Processed on: 11-12-2018

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Exploring mechanisms of

and therapeutic interventions for

microvascular endothelial activation

in shock

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Printing of this thesis was financially supported by:

University of Groningen

University Medical Center Groningen

Cover design: Rui Yan͒

Lay-out design: Pengyu Liu

Printed by: IPSKAMP printing

© Copyright 2018, Rui Yan͒

All rights reserved. No part of this publication may be reproduced

or transmitted in any form or by any means without permission of

the author.

ISBN (printed): 978-94-034-1322-8

ISBN (digital): 978-94-034-1321-1

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Exploring mechanisms of

and therapeutic interventions for

microvascular endothelial

activation in shock

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 28 January 2019 at 14.30 hours

by

Rui Yan

born on 1 December 1986 in Henan, China

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Supervisor

Prof. G. Molema

Co-supervisors

Dr. J. Moser Dr. M. van Meurs

Assessment Committee

Prof. J.L. Hillebrands Prof. R. Masereeuw Prof. A.J. Rabelink

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Paranymphs

Dayang Erna Zulaikha Shuxian Hu

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Chapter 1 9

Introduction and Aims of the thesis

Chapter 2 27

Histone deacetylase inhibition and IkappaB kinase/NF-kappaB blockade ameliorate microvascular pro-inflammatory responses associated with hemorrhagic shock/resuscitation in mice

R. Li, A. Aslan, R. Yan, R.M. Jongman, J. Moser, P. J. Zwiers, H. E. Moorlag, J. G. Zijlstra, G. Molema, M.van Meurs

Crit Care Med. 2015 Dec;43(12):e567-80.

Chapter 3 61

Renal microvasculature specific responses to hemorrhagic shock /resuscitation mice and the effect of NF-κB pathway blockade

R. Yan, M. van Meurs, E.R. Popa, R. Li, P.J. Zwiers, J.G. Zijlstra, J. Moser, G. Molema Shock. 2018 Feb 21.(Epub ahead of print)

Chapter 4 93

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NF-κB

R. Yan, M. van Meurs, E. R. Popa, R.M. Jongman, P.J. Zwiers, A. E. Niemarkt, T. Kuiper, J.A. Kamps, P. Heeringa, J. G. Zijlstra, G. Molema, J. Moser

J Innate Immun. 2017;9(6):546-560.

Chapter 5 125

Kinase activity profiling in LPS-induced inflammatory responses in HUVEC- an in vitro study

Work in progress

Chapter 6 157

Summary, Conclusions, and Future perspectives

Appendices 171

Nederlandse samenvatting Acknowledgements

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About the author - Curriculum Vitae List of publications