University of Groningen
Deacetylase inhibitors & Histone inheritance
Zwinderman, Martijn R. H.
DOI:
10.33612/diss.167867692
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zwinderman, M. R. H. (2021). Deacetylase inhibitors & Histone inheritance. University of Groningen.
https://doi.org/10.33612/diss.167867692
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Deacetylase inhibitors
&
Histone inheritance
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Friday 9 April 2021 at 16.15 hours
by
Reint Harm Zwinderman
born on 17 November 1990
in Winschoten, The Netherlands
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Supervisors
Prof. F. J. Dekker Prof. H. J. HaismaAssessment committee
Prof. R. Gosens Prof. C. Ottmann Prof. J. J. SchuringaThe work described in this thesis was carried out at the Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands.
Cover by Martijn Zwinderman featuring James Watson and Francis Crick. Printed by Gildeprint, Enschede, The Netherlands.
© 2021, Martijn Zwinderman.
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“Ik heb het nog nooit gedaan, dus ik denk dat ik het wel kan.”
Pippi Langkous
“I have never tried that before, so I think I should definitely be able to do
that.”
Pippi Longstocking
2
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Contents
Chapter 1
Introduction
6
Deacetylase inhibitors
Chapter 2
Acetylation and methylation in asthma, COPD, and lung
cancer
18
Chapter 3
Targeting HDAC complexes in asthma and COPD
58
Chapter 4
Effect of Class I selective HDAC inhibitors with an
o-aminobenzamide substituted thiophene scaffold on
inflammatory gene expression in macrophages
82
Histone inheritance
Chapter 5
Bioorthogonal metabolic labeling
132
Chapter 6
Inversion of asymmetric histone deposition upon
replication stress
148
Chapter 7
Summary and future perspectives
190
Appendices
Nederlandse samenvatting
Publications
Posters
Acknowledgements
Curriculum Vitae
198
201
204
206
210
4
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