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University of Groningen

Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy

Saeed, Ali

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

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Publication date:

2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Saeed, A. (2019). Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy.

University of Groningen.

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Acknowledgements

First of all, thanks to Almighty for giving me the strength to achieve this goal. I would like to express my appreciation to those who contributed to this journey. The first person I want to acknowledge is my great father (Saeed Iqbal Anjum). His presence in my life is a great blessing. He gave me all type of support, courage and motivation throughout my life and in my Ph.D. I have no words to say thanks to my respected mother (Ishrat) and parents of my wife (M. Arshad and Sajida Parveen). I have achieved this milestone due to their support, love and prayers. This is impossible to achieve without the sacrifices, love and support of my beloved wife (Memoona

Arshad). She gave tremendous support and care to me and to my kids (M. Rafay Ali and Anaaya). My whole family (Umer, Hasan, Rehman, Shoaib, Awais, Rimsha, Zonra, Farhan , Iqra, Hina, Alvina, Naila and my kids) was with me at each step of

my life and in this journey.

My research in master degree really motivates me towards science. So, I cannot forget to acknowledge my first Scientific supervisor Dr. Qasier Mahemood Khan, my first mentor in science, he provided me very first opportunity to work in a scientific laboratory to express myself. This was also impossible without the funding opportunity provided by BZU, HEC-Pakistan in a great collaboration with

UMCG-RUG. I am grateful to my wonderful colleagues in BZU (Dr. Muhammad Ali, Dr. M. Baber, Dr. Rehan, Dr. Shehzad, Dr. Hammad, Dr. Sumaira, Dr. R. Khalid, Dr. Tahir, Dr. Assad, Dr. Habib, Dr. Samra, Dr. Farhan, Dr. Muzaffar).

Now I want to express my heartfelt thanks of gratitude to my respected supervisor, mentor and a great scientist and real soul of this project, Prof. Dr. Klaas Nico Faber. I am very grateful to him for his intensive, kind and efficient supervision. I am also grateful to him for his highly proficient input in my thesis and publications. He wrote almost several letters of progress report in Pakistan (after every 6-month). I appreciate all his support. Now working as Postdoc in his lab for next 2.5 more years is a great honor for me. Thanks once again for all support, help and supervision! I am extremely thankful to Prof. Dr. Han Moshage. I found him very kind and very nice personality with a great scientific knowledge of this field. His input was also very valuable and precious in my Ph.D. I am indebted to Janette Heegsma, she gave me a great scientific and social support throughout my Ph.D. I appreciate her help and support in my experimental work and all kind of technical assistance. I am also

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Acknowledgements

260

grateful to Manon Buist-Homan and Tjasso Blokzijl for their support and all kind of technical assistance. I learned a lot from these senior technicians.

This achievement is completely a team effort. So, I want to say now special thanks to my team including Mark, Martijn, Floris, Shiva, Joanne, Natalia for their contribution in different projects. I highly appreciated the contribution of Yang. I want to say my affectionate and profound thanks to him for conducting some animal experiments in China for us. I want to say thanks to my MDL-colleagues including

Dianne, Alfredo, Herson, Archie, Turu, Yana Geng, Fabio, Ying Cui, Natalia, Mengfan, Guido, Danial, Raphael, Werna, Arnu.

A heartfelt thanks to some other friends those gave me tremendous support during my Ph.D. including Dicky, Tim, Jan Freark, Brenda, Marleen Schonewille,

Marcella, Ivo, Marije, Federico, Onne, Sandra, Anne Claire, Twan, Vincent, Ingrid, Marleen Dommerholt, Maaike Blankestijn, Sarah Stolle, Fan, Niels, Aycha, Renze, Trijnie, Henk, Hermie, Gaby, Hannah, Hilde, Dolf.

My heartfelt gratitude is also reserved for a few clinicians and scientists including

Maaike H. Oosterveer, Hans Blokzijl, Tim CMA Schreuder, Robin P.F. Dullaart, Henkjan Verkade, Albert Groen, Saskia van Mil, Coen Paulusma, Lu Zhou, Bangmao Wang, Daphne Dekker, Niels Kloosterhuis, Alain de Bruin, Hans Jonker, Bart van de Sluis, Terry G.J. Derks, Eveline Van der Veer, Giles Mithieux, Fabienne Rajas, for collaborations and significant contribution.

I want to say thanks to my Pakistani friends and community including Rana Irfan,

Kashif Bilal, Saleem, Imran Fazal and his family, Ishtiaq Ahmad and his family, Zaheer and his family, Asif, Atta ur Rehman, Ayaz and his family, Kashan Arshad and his family, Sherjeel Aslam, Naveed (late) for their great support. I

would like to say thanks to all my friends in ZCC-Groningen, those provided me the opportunity to play Cricket in The Netherlands.

While writing this section, I was afraid not to miss someone’s name. If I missed someone’s name please accept my apology in advance. This was not my intention. I am also still here for the next couple of years. I still need your support, love and care.

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