University of Groningen
Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy
Saeed, Ali
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Publication date: 2019
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Saeed, A. (2019). Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy. University of Groningen.
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Disturbed vitamin A metabolism in chronic
liver disease and relevance for therapy
This work was supported by the Graduate School of Medical Sciences (GSMS), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. This work was also supported by Bahauddin Zakariya University, Multan, Pakistan and Higher education commission of Pakistan under Yousuf Raza Gilani faculty development Ph.D. scholarships.
The printing of this thesis was financially supported by the following organizations:
Groningen University Institute for Drug Explorations
Nederlandse vereniging voor Hepatologie (NVH)
Their contribution is greatly acknowledged!
© copyright 2019 A. Saeed
All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without written permission of the author and the publisher holding the copyright of the published articles.
ISBN / EAN: 978-94-034-1686-1 (Printed book)
ISBN: 978-94-034-1685-4 (Digital book)
Cover: Designed by A. Saeed
Lay-out by: A. Saeed
Disturbed vitamin A metabolism in chronic
liver disease and relevance for therapy
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. E. Sterken
and in accordance with the decision by the College of Deans.
This thesis will be defended in public on
Tuesday 2 July 2019 at 9.00 hours
by
Ali Saeed
born on 6 January 1984 in Faisalabad, Pakistan
Supervisor Prof. K.N. Faber Co-supervisor Prof. J. Blokzijl Assessment Committee Prof. J.B. Helms Prof. R.K. Weersma Prof. P. Olinga
Paranymphs
Janette Heegsma Manon Buist-Homan
Table of contents
Chapter 1: Introduction and aim of the thesis 9 Chapter 2: The interrelationship between bile acid and vitamin A homeostasis 17
Saeed A, Hoekstra M, Hoeke MO, Heegsma, Faber KN (2017). BBA-Molecular and Cell Biology of Lipids, 1862(5):496-512.
Chapter 3: Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells
75
Shajari S*, Saeed A*, Smith-Cortinez NF, Heegsma J, Sydor S, Faber KN (2019) BBA-molecular and cell biology of lipids, In press. *equal authors
Chapter 4: Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD)
105
Saeed A, Dullaart RPF, Schreuder TCMA, Blokzijl H, Faber KN (2017) Nutrients 2017 Dec 29;10(1). pii: E29. doi: 10.3390/nu10010029
Chapter 5: Hepatic vitamin A metabolism is disturbed in mice with Non-Alcoholic Fatty Liver Disease leading to vitamin A accumulation in hepatocytes
143
Submitted
Chapter 6: Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels
176
Submitted
Chapter 7: Farnesoid X receptor (FXR) and bile acids regulate vitamin A storage 201
In preparation
Chapter 8: Discussion 229
Summary & Samenvatting 251
Acknowledgements 259
