University of Groningen
Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy
Saeed, Ali
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2019
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Saeed, A. (2019). Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy.
University of Groningen.
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Ali Saeed was born on January 6, 1984 in Faisalabad, Pakistan. He finished his bachelor degree (Doctor of Veterinary Medicine) in 2005 and joined his Master degree in the area of Health Biotechnology in Quaid-I-Azam University, Islamabad, Pakistan and finished his degree with successful thesis defense on “Molecular Epidemiology of FMDV in Province Punjab, Pakistan” best public sector institute (NIBGE). This challenging research environment gave him the opportunity to learn advanced scientific methods and to publish his research in well-reputed journals. He has research and teaching experience before the start of Ph.D. He worked as Veterinary Officer (Health) (1.10 years) and lecturer/researcher in Institute of Molecular biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan (3.7 years). He got faculty development Ph.D. scholarship from Bahauddin Zakariya University, Multan, Pakistan-funded by higher education commission of Pakistan. April 2013, He joined the group of Prof. Dr. Klaas Nico Faber, in the department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands as a Ph.D. student. His research topic was “Disturbed vitamin A metabolism in chronic liver disease and relevance for therapy”. Since June 1, 2018, he was appointed as a post-doctoral fellow in the same department and supervision. Now his research topic is “Modulating gut host-microbe interactions in a human in vitro (HoxBan) system to develop pre/pro-biotic therapies for Inflammatory Bowel Disease”.
LIST OF PUBLICATIONS
1. Ali Saeed, Mark Hoekstra, Martijn Oscar Hoeke, Janette Heegsma, Klaas Nico Faber. The interrelationship between bile acid and vitamin A homeostasis,
Biochim. Biophys. Acta. (Molecular and cell biology of lipids). 1862 (2017) 496–
512.
2. Shiva Shajari*, Ali Saeed*, Janette Heegsma, Natalia F. Smith-Cortinez, Svenja Sydor, Klaas Nico Faber. Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells. (Conditionally accepted).
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3. Ali Saeed, Robin P.F. Dullaart, Tim C.M.A. Schreuder, Hans Blokzijl, Klaas Nico Faber. Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients 10, 29 (2017).4. Ali Saeed, Paulina Bartuzi, Janette Heegsma., Daphne Dekker., J.W. (Hans) Jonker., A.J.A. (Bart) van der Sluis., Klaas Nico Faber. Non-alcoholic fatty liver disease disturbs vitamin A metabolism leading to enhanced storage in the liver, but normal circulatory retinol (Submitted).
5. Ali Saeed, Joanne A. Hoogerland, Janette Heegsma, Terry G.J. Derks, Eveline van der Veer, Gilles Mithieux, Fabienne Rajas, Maaike H. Oosterveer, Klaas Nico Faber. Impaired vitamin A homeostasis in glycogen storage disease type 1a (Submitted).
6. Ali Saeed, Jing Yang, Janette Heegsma, Albert K. Groen, Saskia W.C. van Mil, Coen C. Paulusma, Lu Zhou, Bangmao Wang, Klaas Nico Faber. Farnesoid X receptor (FXR) and bile acids regulate vitamin A storage (In preparation). 7. Muhammad Munir, Ali Saeed, Muhammad Abubakar, Sehrish Kanwal and
Mikael Berg. Molecular Characterization
of Peste des Petits Ruminants Viruses From Outbreaks Caused by Unrestricted Movements of Small Ruminants in Pakistan, Transboundary and Emerging
Diseases. 62 (1), 108-114 (2015).
8. Ali Saeed, Sehrish Kanwal, Memoona Arshad, Rehan Sadiq Shaikh, Muhammad Ali, Muhammad Abubakar. Foot-and-mouth disease: overview of motives of disease spread and efficacy of available vaccines. Journal of Animal
Science and Technology. 57 (1), 10 (2015).
9. Sehrish Kanwal, Ali Saeed, Muhammad Munir, Memoona Arshad.
Phylogenetics of Foot and Mouth Disease Virus in Punjab, Pakistan. British
Journal of Virology. 1(1): 21-28 (2014) .
10. Usman Waheed, Muhammad Siddique, Muhammad Arshad, Muhammad Ali, Ali Saeed. Preparation of OE Newcastle disease vaccine from VG/GA strain and its evaluation in commercial broiler chicks. Pakistan Journal of Zoology. 45(2), 339-344 (2013).
11. Muhammad Munir, Siamak Zohari, Ali Saeed, Qaiser Mahmood Khan, Muhammad Abubakar, Neil LeBlanc, Mikael Berg. Detection and phylogenetic analysis of Peste des Petits Ruminants Virus isolated from outbreaks in Punjab, Pakistan. Transboundary and Emerging Diseases. 59 85–93 (2012).
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12. Samreen Zulfiqar, Sadia Shahnawaz, Muhammad Ali, Arif Mahmood Bhutta, Shahid Iqbal, Sikandar Hayat, Shazia Qadir, Muhammad Latif, Nazia Kiran, Ali Saeed, Muhammad Ali, Furhan Iqbal. Detection of Babesia bovis in blood samples and its effect on the hematological serum biochemical profile in large ruminants from southern Punjab. Asian Pacific Journal of Tropical Biomedicine. 104-108 (2012).13. Farhan Afzal, Ali Saeed, Muhammad Azhar Sharif, Najma Ayub, Shamsul Hassan. Pathogenicity of avian influenza virus H5N1 2007 isolates from Pakistan. Asian Pacific Journal of Tropical Biomedicine. S380-S382, (2012). 14. Ali Saeed, Farhan Afzal, Memoona Arshad, Shamsul Hassan and Muhmmad
Abuabakar “Detection of avian Influenza virus H5N1 serotype in backyard poultry, wild and zoo birds in Pakistan”. Revue de Médecine Vétérinaire. 163(11), 552-557 (2012).
15. Muhammad Abubakar , Sehrish Kanwal, Ali Saeed. Persistence, Emergence and Distribution of Foot and Mouth Disease Virus (FMDV); Global and Pakistan Perspectives. Pakistan Journal of Life and Social Sciences. 10(2): 84-90 (2012). (Review Article)
16. Ali Saeed, Qaiser Mahmood Khan, Usman Waheed, Memoona Arshad, Muhammad Asif, Muhammad Farooq. RT-PCR evaluation for identification and sequence analysis of foot-and-mouth disease serotype O from 2006 to 2007 in Punjab, Pakistan. Comparative Immunology, Microbiology and Infectious
Diseases. 34, pp. 95-101 (2011).
17. Ali Saeed, Usman Waheed, Memoona Arshad, Qaiser Mahmood Khan, Muhammad Ali, Muhammad Baber. RT-PCR evaluation of foot-and-mouth disease serotype O in saliva, tracheal and vesicular samples of goats in Punjab, Pakistan. Pakistan Journal of Zoology. 43(4), 808-811 (2011).
18. Usman Waheed, Ali Saeed, Ameena Mobeen, Qaiser Mahmood Khan. The VP1 (Capsid Protein) Gene Based DNA Sequencing for Epidemiological Analysis of FMDV, Isolated from Buffaloes in Pakistan. Pakistan Journal of Zoology. Supplementary series, No.9 pp.333-339 (2009).
CONFERENCES
1. Ali Saeed, Paulina Bartuzi, Janette Heegsma, Daphne Dekker, Niels Kloosterhuis, Alain de Bruin, Johan W. Jonker, Bart van der Sluis, Klaas Nico
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264
Faber. Hepatic vitamin A metabolism is disturbed in mice with Non-Alcoholic Fatty Liver Disease leading to vitamin A accumulation in hepatocytes. AmericanAssociation for the Study of Liver Diseases (AASLD-2018), 09–13 November
2018, San Francisco, USA.
2. Ali Saeed, Paulina Bartuzi, Janette Heegsma, Daphne Dekker, Niels Kloosterhuis, Alain de Bruin, Johan W. Jonker, Bart van der Sluis, Klaas Nico Faber. Hepatic vitamin A metabolism is disturbed in mice with Non-Alcoholic Fatty Liver Disease leading to vitamin A accumulation in hepatocytes. European
Club for Liver Cell Biology (ECLCB-8), 04–06 October 2018, Bonn, Germany. 3. Ali Saeed, Paulina Bartuzi, Janette Heegsma, Daphne Dekker, A.J.A. (Bart)
van der Sluis, Klaas Nico Faber. Hepatic vitamin A metabolism is disturbed in mice with Non-Alcoholic Fatty Liver Disease leading to vitamin A accumulation in hepatocytes. 2nd European Fatty Liver Conference (2nd EFLC 2018), 28 February–2 March Maastricht, 2018, The Netherlands.
4. Ali Saeed, Joanne A. Hoogerland, Janette Heegsma, Terry G.J. Derks, Eveline van der Veer, Gilles Mithieux, Fabienne Rajas, Maaike H. Oosterveer* and Klaas Nico Faber. Retinol levels are elevated in circulation, but reduced in liver in Glycogen storage disease type Ia. NVL-Dutch Liver Retreat 2018 (DLR2018), 1-2 February 2018, Spier, The Netherlands. (Oral presentation).
5. Ali Saeed, Martijn Oscar Hoeke, Mark Hoekstra, Janette Heegsma, Han Moshage, Klaas Nico Faber. Vitamin A deficiency leads to mild cholestasis and a “humanized” bile acid profile in rats. Symposium 203, XXIV International Bile
Acid Meeting: Bile Acids in Health and Disease. 17-18 June 2016, Düsseldorf,
Germany. (Poster wins 3rd position in the conference)
6. Ali Saeed, Mark Hoekstra, Martijn Oscar Hoeke, Janette Heegsma, Han Moshage, Klaas Nico Faber. Vitamin A deficiency promotes hepatic expansion of resident (Kupffer cells) and peripheral (Grhi) macrophages leading to
excessive liver damage in rats with obstructive cholestasis. Annual 66th Liver
Meeting®, AASLD, 13-17 November 2015, Moscone West Convention Center,
San Francisco, California, USA. (Poster)
7. Ali Saeed, Mark Hoekstra, Martijn Oscar Hoeke, Janette Heegsma, Han Moshage, Klaas Nico Faber. Vitamin A controls the expression of inflammatory cytokines and macrophage numbers in obstructive cholestasis in rat.
NVL-265
Dutch Liver Retreat (5th DLR2014), 30th and 31th October 2014, Spier, The
Netherlands. (Oral presentation)
8. Mark Hoekstra, Martijn Oscar Hoeke, Janette Heegsma, Renze Boverhof, Ali Saeed, V.W. (Vincent) Bloks, Han Moshage, and Klaas Nico Faber. Vitamin A promotes the synthesis of biliary beta-muricholic acid in rat. NVL-Dutch Liver
Retreat (4th DLR2013), 26th and 27th September,2013, Spier, The Netherlands.
(Oral presentation)
9. Ali Saeed, Uman Waheed, Muhammad Ali, Muhammad Ali, Muhammad Qaiser Khan. Foot-and-mouth disease detection by RT-PCR from original field materials from Multan district of Punjab, Pakistan; Abstract is published in
National Conference Bahauddin Zakariya University, Multan. 13 October, 2010,
Multan, Pakistan. (Abstract)
10. Uman Waheed, Ali Saeed, Ehtisham-ul-Haque, Qaiser Mahmood Khan. Diagnosis of recent outbreak of FMD in different districts of Punjab, Pakistan through RT-PCR; National Conference Rawlakot 21-23, July 2010, Rawlakot, Pakistan. (Abstract)
11. Qaiser Mahmood Khan, Uman Waheed, Sabir Farooq, Ali Saeed, Muhammad Farooq. PCR based detection and epidemiology of FMDV and PPRV in field samples from Punjab, Pakistan. FAO/IAEA international symposium on sustainable improvement of animal production and health. Synopses, Vienna
(Austria); 8-11 Jun 2009; IAEA-CN--174/93.
12. Uman Waheed, Ali Saeed, Muhammad Asif, Qaiser Mahmood Khan. Phylogenetic Analysis on the Basis of Amplified VP1 (Capsid Protein) Gene of FMDV in Clinical Samples from Punjab Areas. Plenary talk - Prof. M.I.D. Chughtai Memorial Lecture. 9th Biennial Conference Pakistan Society for
Biochemistry and Molecular Biology, Arid Agriculture University, Rawalpindi,
Dec. 17-18, 2008. Page 51. Rawalpindi, Pakistan. (Oral presentation)
13. Usman Waheed, Ali Saeed, Muhammad Asif, Qaiser Mahmood Khan. Amplification of VP1 (capsid protein) gene of FMDV in clinical samples from Punjab, Pakistan and its phylogeny. 35th All Pakistan Science Conference, December 22-23 (2008), Karachi-Pakistan. (Abstract)
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266
BOOK CHAPTERS
1) Ali Saeed, Muhammad Abubakar and Oguz Kul. Modification of Animal Products for Fat and Other Characteristics. Modification of Animal Products for Fat and Other Characteristics, pp 55-89. ISBN 978-3-662-46789-3, (2015) (eBook).
2) Ali Saeed, Ali H. Sayyed, Sohail Safdar and Shumaila Manzoor. Reduction in Animal Waste, pp 111-134. ISBN 978-3-662-46789-3, (2015) (eBook).
3) Ali Saeed, Muhammad Abubakar and Sehrish Kanwal. Future Challenges Related to Animal Biotechnology. Modification of Animal Products for Fat and Other Characteristics, pp 135-147. ISBN 978-3-662-46789-3, (2015) (eBook).
BOOKS
1) Muhammad Abubakar, Ali Saeed, Oguz Kul. The Role of Biotechnology in Improvement of livestock. Animal health and biotechnology, pp 1-147. ISBN 978-3-662-46788-6; ISBN 978-3-662-46789-3 (eBook). (DOI 10.1007/978-3-662-46789-3) (2015). (Editor of book).
2) Ali Saeed, Muhammad Abubakar, Qaiser Mahmood Khan. Foot and Mouth Disease Virus (FMDV); Molecular Epidemiology of FMDV in Province Punjab, Pakistan. LAP LAMBERT Academic Publishing (2011-09-05).
