University of Groningen
Applying lipidomics strategies to study lipid metabolic diseases Zhang, Wenxuan
DOI:
10.33612/diss.169407826
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Publication date: 2021
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Citation for published version (APA):
Zhang, W. (2021). Applying lipidomics strategies to study lipid metabolic diseases. University of Groningen. https://doi.org/10.33612/diss.169407826
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1. Lipids are taking essential roles in energy storage, signal transduction, membrane construction and more, therefore, lipidomics strategies are essential to gain insight in lipid related biological processes. -This thesis
2. Pre-analytical stage is crucial for any lipidomics experiment. -This thesis
3. Lipidomics is emerging as a useful tool for lipid biomarker discovery in clinical and population cohorts. -This thesis
4. Triglycerides have the capability to cope with excessive amount of medium chain fatty acids which are produced in MCAD KO mice model under stress conditions.
-This thesis
5. LRH-1 plays an important role in protecting liver from developing NASH under Western-type diet, partially by mediating adaptations of lipid metabolism. -This thesis
6. Merging lipidomics with genomics and proteomics data helps identifying novel modes of regulation in lipid metabolism. -This thesis
7. Standardization and harmonization of lipidomics workflows is the key to its widespread use for clinical application in diagnostics of inborn errors in lipid metabolism .
8. Solid knowledge of metabolism is the prerequisite of interpretation of lipidomics data.
9. Knights are like proteins. Each knight has a pedigree, a story, an emblem, a flag. Lipids are like armies. Knights are more visible. It’s easier to write poetry about them, but in the end it’s the army that wins, the collective of individuals. That’s the lipids. - Andrej Shevchenko (2011)
10. Life has so much to offer. Life is full of possibilities. You just need to know where to see. - Joe Gardner
(2020)
