University of Groningen
In silico strategies to improve insight in breast cancer
Bense, Rico
DOI:
10.33612/diss.101935267
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bense, R. (2019). In silico strategies to improve insight in breast cancer. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.101935267
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
IN SILICO STRATEGIES TO IMPROVE
INSIGHT IN BREAST CANCER
Printing of this thesis was financially supported by the Graduate School of Medical Sciences, Stichting Werkgroep Interne Oncologie, and the University of Groningen.
Cover: Remco Wetzels
Printed by: ridderprint.nl
ISBN: 978-94-034-2156-8
ISBN (electronic version): 978-94-034-2155-1 © 2019 R.D. Bense
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without prior written permission of the author.
In silico strategies to improve
insight in breast cancer
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 20 november 2019 om 16.15 uur
door
Rico Delano Bense
geboren op 15 augustus 1991 te Venlo
Promotores
Prof dr. E.G.E. de Vries Dr. C.P. Schröder
Copromotor
Dr. R.S.N. Fehrmann
Beoordelingscommissie
Prof dr. T.N. Wijmenga Prof dr. E. van der Wall Prof dr. H. Hollema
Paranifmen
Arkajyoti Bhattacharya Maarten Huismans
CONTENTS
Chapter 1 General introduction 9
Chapter 2 Considering the biology of late recurrences in selecting patients for extended endocrine therapy in breast cancer Cancer Treat Rev. 2018;70:118-126
15
Chapter 3 Relevance of tumor-infiltrating immune cell composition and functionality for disease outcome in breast cancer
J Natl Cancer Inst. 2017;109:djw192
37
Chapter 4 Consideration of breast cancer subtype in targeting the androgen receptor
Pharmacol Ther. 2019;200:135-147
85
Chapter 5 Transcriptional effects of copy number alterations and their associations with biological processes in a large set of human cancers
Submitted
117
Chapter 6 Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types
Oncotarget. 2015;6:28164-28172
151
Chapter 7 Discussion and future perspectives 165
Chapter 8 Nederlandse samenvatting (Dutch summary) 173
